FUS-mediated BBB opening reshapes plasma extracellular vesicle size distribution without elevating concentration in glioblastoma patients [0.03%]
FUS介导的血脑屏障开启不会增加胶质母细胞瘤患者血浆中细胞外囊泡浓度但会改变其尺寸分布
Massimiliano Del Bene,Daniela Osti,Marta Bonada et al.
Massimiliano Del Bene et al.
Background: Focused ultrasound-mediated blood-brain barrier opening (BBBO) is hypothesized to enhance liquid biopsy by facilitating the release of tumor material into the circulation. This study aimed to evaluate the impa...
Differences in Primary Molecular Subtype Distribution Contribute to Racial and Ethnic Disparities in Adult-Type Diffuse Gliomas [0.03%]
成人型弥漫性胶质瘤主要分子亚型分布的差异造成了种族和族裔差距
David Gomez,Ishan Shah,David J Cote et al.
David Gomez et al.
Background: Molecular profiling has become an integral part of glioma classification. The extent to which incidence of molecularly-defined adult-type gliomas vary by demographics is unknown. We describe national-level inc...
Integrating androgen signaling tumor dependency with host neuroendocrine immunity for glioblastoma therapies [0.03%]
雄激素信号通路依赖性与宿主神经内分泌免疫在胶质母细胞瘤治疗中的整合研究
Iris Lavon,Alexander Lossos,Nima Sharifi et al.
Iris Lavon et al.
iPSC-derived NK cell therapy induces durable responses in glioblastoma and overcomes resistance via a B7-H3-targeted tri-specific killer engager [0.03%]
基于iPSC的NK细胞疗法诱导胶质母细胞瘤持久应答并通过B7-H3靶向的三特异性杀手衔接物克服耐药性
Jian-Fang Ning,Zachary B Davis,Qudsia Zeb et al.
Jian-Fang Ning et al.
Background: Glioblastoma is the most aggressive primary brain tumor, with poor prognosis and limited treatment options. Natural killer (NK) cell therapy is a promising immunotherapeutic strategy, yet its efficacy remains ...
The European Association for Neuro-oncology (EANO) Consensus Statement on Radiation Necrosis [0.03%]
欧洲神经肿瘤学会(EANO)关于放射性坏死的共识声明
Johnny Duerinck,Martin Van Den Bent,Petter Brandal et al.
Johnny Duerinck et al.
Introduction: Radiation necrosis (RN) complicates neuro-oncological care, mimicking tumor recurrence and lacking high-level evidence for standardized management. ...
Comprehensive Performance Testing and External Validation of an AI Algorithm to Detect and Segment Brain Metastases [0.03%]
全面检测和外部验证一种AI算法在检测和分割脑转移瘤方面的性能
Rupesh Kotecha,Eyub Y Akdemir,Naseem Ud Din et al.
Rupesh Kotecha et al.
Background: Artificial intelligence (AI)-based models have shown initial promise in imaging brain metastasis; however many lack validation against advanced imaging-informed datasets, precluding external validity and limit...
Susan M Chang
Susan M Chang
Inferring DNA Methylation Class from Digitized Pathology Images and AI: A Worthy and Timely Application with Room for Improved Clinical Performance [0.03%]
基于数字化病理图像和AI推断DNA甲基化类型：一项值得且及时的应用，但仍需提高临床表现性能
Marina Ayad,Lee A D Cooper,Daniel J Brat
Marina Ayad
Linpeng Zhang,Hesong Wang,Guangrui Huang et al.
Linpeng Zhang et al.
Background: Thalamic gliomas (TGs) remain a formidable clinical challenge for accurate diagnosis and effective therapy. This study aims to refine molecular diagnosis and surgical management of TGs by integrating clinicopa...
MAPK-driven glioma progression and reprogramming of the tumor-associated immune response [0.03%]
MAPK驱动的胶质瘤进展和肿瘤相关免疫反应的重新编程
Elaheh Hashemi,Ravishkumar Lakshmi Akshaya,Lin Wang et al.
Elaheh Hashemi et al.
Background: In brain tumors, the immunosuppressive microenvironment leads to tumor aggressiveness and immunotherapy resistance. To identify factors that regulate the glioma immune landscape, we took advantage of the disea...