Alan E Lomax,Sabindra Pradhananga,Jessica L Sessenwein et al.
Alan E Lomax et al.
The potential role of the intestinal microbiota in modulating visceral pain has received increasing attention during recent years. This has led to the identification of signaling pathways that have been implicated in communication between g...
Characterization and mechanism of the esophago-esophageal contractile reflex of the striated muscle esophagus [0.03%]
横纹肌食管的食管-食管收缩反射的功能特征及机制研究
Ivan M Lang,Bidyut K Medda,Reza Shaker
Ivan M Lang
An esophago-esophageal contractile reflex (EECR) of the cervical esophagus has been identified in humans. The aim of this study was to characterize and determine the mechanisms of the EECR. Cats (n = 35) were decerebrated, electrodes were p...
Load-bearing function of the colorectal submucosa and its relevance to visceral nociception elicited by mechanical stretch [0.03%]
结肠粘膜下层的支撑功能及其对机械牵张诱发的内脏痛觉过敏的的意义
Saeed Siri,Franz Maier,Stephany Santos et al.
Saeed Siri et al.
Mechanical distension beyond a particular threshold evokes visceral pain from distal colon and rectum (colorectum), and thus biomechanics plays a central role in visceral nociception. In this study we focused on the layered structure of the...
Activity within specific enteric neurochemical subtypes is correlated with distinct patterns of gastrointestinal motility in the murine colon [0.03%]
特异性肠神经化学亚型内的活性与小鼠结肠中不同模式的胃肠道运动相关
Thomas W Gould,William A Swope,Dante J Heredia et al.
Thomas W Gould et al.
The enteric nervous system in the large intestine generates two important patterns relating to motility: 1) propagating rhythmic peristaltic smooth muscle contractions referred to as colonic migrating motor complexes (CMMCs) and 2) tonic in...
Temporal induction of intestinal epithelial hypoxia-inducible factor-2α is sufficient to drive colitis [0.03%]
肠道上皮缺氧诱导因子-2α瞬时表达即可引发结肠炎
Sumeet Solanki,Samantha N Devenport,Sadeesh K Ramakrishnan et al.
Sumeet Solanki et al.
Hypoxia is a notable feature of inflammatory bowel disease and chronic induction of hypoxia-inducible factor (HIF)-1α and HIF-2α (endothelial PAS domain protein 1, EPAS1) play important, but opposing, roles in its pathogenesis. While acti...
Deletion of organic cation transporter Oct3 promotes hepatic fibrosis via upregulation of TGFβ [0.03%]
有机阳离子转运蛋白Oct3的缺失通过TGFβ上调促进肝纤维化
Johanna Vollmar,Yong Ook Kim,Jens U Marquardt et al.
Johanna Vollmar et al.
Organic cation transporters (OCT) are responsible for the intracellular uptake and detoxification of a broad spectrum of endogenous and exogenous substrates. OCTs are downregulated in cholestasis, fibrosis, and hepatocellular carcinoma, but...
Yanyan Jiang,Beverley Greenwood-Van Meerveld,Anthony C Johnson et al.
Yanyan Jiang et al.
Symptoms of functional gastrointestinal disorders (FGIDs), including fullness, bloating, abdominal pain, and altered gastrointestinal (GI) motility, present a significant clinical problem, with a reported prevalence of 25%-40% within the ge...
Cardiac dysfunction in cirrhosis: a 2-yr longitudinal follow-up study using advanced cardiac imaging [0.03%]
肝硬化患者的心脏功能障碍：为期两年的前瞻性心脏影像研究
Signe Wiese,Jens D Hove,Silje Mo et al.
Signe Wiese et al.
The temporal relationship between cirrhotic cardiomyopathy, progression of liver disease, and survival remains unknown. Our aim was to investigate the development of structural and functional cardiac changes over time with the progression o...
Deoxycholic acid activates colonic afferent nerves via 5-HT3 receptor-dependent and -independent mechanisms [0.03%]
脱氧胆酸通过5-ht3受体依赖和非依赖机制激活结肠传入神经
Yang Yu,Egina C Villalobos-Hernandez,Sabindra Pradhananga et al.
Yang Yu et al.
Increased bile acids in the colon can evoke increased epithelial secretion resulting in diarrhea, but little is known about whether colonic bile acids contribute to abdominal pain. This study aimed to investigate the mechanisms underlying a...
Portal hyperperfusion after major liver resection and associated sinusoidal damage is a therapeutic target to protect the remnant liver [0.03%]
肝切除术后门脉高压和肝窦损伤是保护残余肝脏的治疗靶点
Andreas Kohler,Per W Moller,Sabrina Frey et al.
Andreas Kohler et al.
Extended liver resection results in loss of a large fraction of the hepatic vascular bed, thereby causing abrupt alterations in perfusion of the remnant liver. Mechanisms of hemodynamic adaptation and associated changes in oxygen metabolism...