Inhibition of soluble epoxide hydrolase ameliorates hyperhomocysteinemia-induced hepatic steatosis by enhancing β-oxidation of fatty acid in mice [0.03%]
通过增强脂肪酸的β氧化缓解高同型半胱氨酸血症诱导的小鼠肝脂肪变性作用的研究溶致可溶性环氧合酶抑制剂的研究
Liu Yao,Boyang Cao,Qian Cheng et al.
Liu Yao et al.
Hepatic steatosis is the beginning phase of nonalcoholic fatty liver disease, and hyperhomocysteinemia (HHcy) is a significant risk factor. Soluble epoxide hydrolase (sEH) hydrolyzes epoxyeicosatrienoic acids (EETs) and other epoxy fatty ac...
Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents [0.03%]
胆酸驱动rodents的结肠分泌胰高血糖素样肽1和肽 YY
Charlotte Bayer Christiansen,Samuel Addison Jack Trammell,Nicolai Jacob Wewer Albrechtsen et al.
Charlotte Bayer Christiansen et al.
A large number of glucagon-like-peptide-1 (GLP-1)- and peptide-YY (PYY)-producing L cells are located in the colon, but little is known about their contribution to whole body metabolism. Since bile acids (BAs) increase GLP-1 and PYY release...
Mucosal RNA and protein expression as the next frontier in IBS: abnormal function despite morphologically intact small intestinal mucosa [0.03%]
肠易激综合征(IBS)的粘膜RNA和蛋白表达作为下一个研究前沿：小肠粘膜结构完整而功能异常
Bruno Kotska Rodiño-Janeiro,Cristina Pardo-Camacho,Javier Santos et al.
Bruno Kotska Rodiño-Janeiro et al.
Irritable bowel syndrome (IBS) is one of the commonest gastrointestinal disorders. Although long-time considered a pure functional disorder, intense research in past years has rendered a very complex and varied array of observations indicat...
Gut microbiota in liver disease: too much is harmful, nothing at all is not helpful either [0.03%]
肠道微生态与肝脏疾病：过多有害，缺少不济
Phillipp Hartmann,Huikuan Chu,Yi Duan et al.
Phillipp Hartmann et al.
The intestinal microbiome plays a major role in the pathogenesis of liver disease, with a hallmark event being dysbiosis, or an imbalance of pathobionts and beneficial bacteria with the associated deleterious effects on their host. Reducing...
Caroline E Geisler,Susma Ghimire,Randy L Bogan et al.
Caroline E Geisler et al.
Ketosis is a metabolic adaptation to fasting, nonalcoholic fatty liver disease (NAFLD), and prolonged exercise. β-OH butyrate acts as a transcriptional regulator and at G protein-coupled receptors to modulate cellular signaling pathways in...
Necrostatin-1 accelerates time to death in a rat model of cecal ligation and puncture and massively increases hepatocyte caspase-3 cleavage [0.03%]
Necrostatin-1加速盲肠结扎穿孔术大鼠模型的死亡时间并极大地增加肝细胞caspase-3切割率
Qin Zhang,Siwei Wei,Jiayin Lu et al.
Qin Zhang et al.
Necroptosis, a form of regulated necrosis, has been reported to be involved in numerous pathologies, including sepsis. However, a protective effect of the selective inhibitor of necroptosis, necrostatin-1 (Nec-1), against sepsis remains to ...
Chronic colitis-induced visceral pain is associated with increased anxiety during quiescent phase [0.03%]
慢性结肠炎引起的内脏疼痛在静止期与焦虑增加有关
Emmeline Salameh,Mathieu Meleine,Guillaume Gourcerol et al.
Emmeline Salameh et al.
Inflammatory bowel diseases (IBD) are characterized by repetition of flares and remission periods leading to chronic postinflammatory sequelae. Among postinflammatory sequelae, one-third of patients with IBD are suffering from functional sy...
lncRNA GAS5 restrains CCl4-induced hepatic fibrosis by targeting miR-23a through the PTEN/PI3K/Akt signaling pathway [0.03%]
长链非编码RNA GAS5通过PTEN/PI3K/Akt信号通路靶向miR-23a抑制CCl4诱导的肝纤维化
Zhiheng Dong,Sha Li,Xiaohui Wang et al.
Zhiheng Dong et al.
Hepatic fibrosis is chronic liver damage with many causes that has a relatively high death rate. The current study showed that long noncoding RNA (lncRNA) growth arrest-specific transcript 5 (GAS5), microRNA-23a (miR-23a), and phosphatase a...
Preservation of reserve intestinal epithelial stem cells following severe ischemic injury [0.03%]
严重缺血损伤后保留肠上皮干细胞的保存
Liara M Gonzalez,Amy Stieler Stewart,John Freund et al.
Liara M Gonzalez et al.
Intestinal ischemia is an abdominal emergency with a mortality rate >50%, leading to epithelial barrier loss and subsequent sepsis. Epithelial renewal and repair after injury depend on intestinal epithelial stem cells (ISC) that reside with...
Ethanol withdrawal mitigates fatty liver by normalizing lipid catabolism [0.03%]
乙醇戒断通过恢复正常脂质分解改善脂肪肝
Paul G Thomes,Karuna Rasineni,Li Yang et al.
Paul G Thomes et al.
We are investigating the changes in hepatic lipid catabolism that contribute to alcohol-induced fatty liver. Following chronic ethanol (EtOH) exposure, abstinence from alcohol resolves steatosis. Here, we investigated the hepatocellular eve...