Temporal induction of intestinal epithelial hypoxia-inducible factor-2α is sufficient to drive colitis
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Hypoxia is a notable feature of inflammatory bowel disease and chronic induction of hypoxia-inducible factor (HIF)-1α and HIF-2α (endothelial PAS domain protein 1, EPAS1) play important, but opposing, roles in its pathogenesis. While activation of HIF-1α de... ...
