Colonic metabolomic and transcriptomic alterations in a mouse model of metabolic syndrome [0.03%]
代谢综合征小鼠模型结肠内代谢组学和转录组学的改变
Jaclyn A Rivas,David P Scieszka,Eduardo Peralta-Herrera et al.
Jaclyn A Rivas et al.
Metabolic syndrome (MetS), characterized by abdominal obesity, insulin resistance, dyslipidemia, and hypertension, affects a substantial proportion of the global population and increases the risk for cardiovascular disease, diabetes, and me...
Contrasting Impacts of Two ABCB11 Variants Affecting the Same Residue in Progressive Familial Intrahepatic Cholestasis Type 2 [0.03%]
两种影响进行性家族性肝内胆汁淤积症2型中同一残基的ABCB11变异体的不同影响的对比研究
Yosra Riahi,Marion Almes,Manon Banet et al.
Yosra Riahi et al.
Progressive Familial Intrahepatic Cholestasis Type 2 (PFIC2) is a severe autosomal recessive cholestatic liver disease due to variations in ABCB11. Clinical and molecular consequences of two missense variations affecting the same ABCB11 res...
Radiotherapy reduces ATP-mediated relaxation in human rectal smooth muscle [0.03%]
放射治疗降低人类直肠平滑肌中ATP介导的松弛作用
Yoon-Hye Kwon,Tae Sik Sung,Young Hyun Yun et al.
Yoon-Hye Kwon et al.
Radiation therapy for rectal cancer often causes long-term bowel dysfunction. We investigated radiation-associated motility changes in human rectal smooth muscle, focusing on the role of platelet-derived growth factor receptor alpha-positiv...
Host-microbe Interactions in the Appendix of Children with Inflammatory Bowel Diseases [0.03%]
儿童炎症性肠病患者的阑尾中的宿主微生物相互作用
Nazanin Arjomand Fard,John Maringa Githaka,Simona Veniamin et al.
Nazanin Arjomand Fard et al.
The human appendix is traditionally considered a vestigial organ; however, clinical observations link it to inflammatory bowel diseases (IBD), including Crohn disease and ulcerative colitis (UC), as suggested by peri-appendicular inflammati...
Phase-dependent Disruption of Microbiome-Metabolome Coordination Is Associated with Diet-Induced MASLD [0.03%]
与饮食诱导的MASLD相关的相依赖性破坏微生物组-代谢物协调作用
Arka Jyoti De,Bibek Upadhyaya,Palok Aich
Arka Jyoti De
Metabolic-dysfunction-associated steatotic liver disease (MASLD) is typically attributed to caloric overload, lipotoxicity, and static gut dysbiosis, but how chronic diet alters the temporal organization of gut-liver communication remains u...
E-cadherin acts as a dynamic switch in epithelial regeneration in inflammatory bowel disease [0.03%]
E-钙粘蛋白在炎症性肠病上皮再生中作为动态开关的作用
Bereket Girma,Hammed Ayansola,Jiecheng Chen et al.
Bereket Girma et al.
Effective epithelial regeneration is crucial for mucosal healing to achieve complete remission in patients with inflammatory bowel disease (IBD). E-cadherin (Cdh1), a key transmembrane protein mediating epithelial cell-cell adherence, must ...
Genetic and pharmacologic modulations elucidate NRF2 protective role in acute pancreatitis [0.03%]
基因和药理学调控阐明NRF2在急性胰腺炎中的保护作用
Olga A Mareninova,Alex G Chang,Sebastian Hernandez Malpica et al.
Olga A Mareninova et al.
Acute pancreatitis (AP) is a potentially fatal disease of the exocrine pancreas. The disease pathogenesis remains obscure, and no effective treatment is available. Uncontrolled, deregulated inflammation is a major cause of systemic complica...
Aldosterone suppresses Na⁺/H⁺ exchanger-3 expression through miR-204-5P-mediated post-transcriptional regulation in distal colon [0.03%]
醛固酮通过miR-204-5P介导的转录后调控抑制远端结肠Na⁺/H⁺交换器-3表达
Karthikeyan Narayanan,Kumaran M Rajendran,Joshua Cornman-Homonoff et al.
Karthikeyan Narayanan et al.
Na⁺/H⁺ exchanger-3 (NHE3) is a major mediator of electroneutral NaCl absorption in the intestine and colon. In distal colon, chronic aldosterone exposure suppresses NHE3 expression, but the molecular mechanism responsible for this regulat...
Physical, chemical, and structural properties of human gastric organoid-derived mucus [0.03%]
人源胃类器官黏液的物理、化学和结构特性
Katrina N Lyon,Barkan Sidar,Jasper Gattiker et al.
Katrina N Lyon et al.
The gastric mucus layer protects the epithelium from gastric acid and ingested pathogens. However, studies of human gastric mucus have been limited due to poor accessibility of native human mucus and the abundance of contaminants in these s...
High-oxygen gas-permeable culture improves viability and supports quantitative antifibrotic pharmacology in precision-cut liver slices [0.03%]
高氧通气培养可提高肝脏精密切片的活力并支持抗纤维化药理学定量研究
Yusaku Komoike,Hideyuki Hiyoshi,Teruyoshi Yamashita et al.
Yusaku Komoike et al.
Liver fibrosis remains a major unmet medical need, and quantitative evaluation of antifibrotic candidates requires ex vivo models that preserve tissue function while supporting higher-throughput pharmacological testing. Precision-cut liver ...