From Rodents to Chips: Preclinical Models of Inflammatory Bowel Disease with Emphasis on Host-Microbiome Interactions [0.03%]
从啮齿类动物到芯片：炎症性肠病的临床前模型及其宿主-微生物群相互作用研究
Satish Kumar,Biswatrish Sarkar
Satish Kumar
Inflammatory bowel disease (IBD), comprising Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder with steadily increasing global prevalence, significantly impairing patient quality of life. Preclinical resea...
Regulatory T cells are induced by gut microbiota through differentially regulating costimulatory molecules of enteric glial cells [0.03%]
肠神经系统中的调节性T细胞由肠道微生物通过差异调节肠神经胶质细胞共刺激分子诱导产生
Jiahui Yang,Qishan Zeng,Min Zou et al.
Jiahui Yang et al.
Probiotics have been proven to be effective in inducing and maintaining remission of inflammatory bowel disease (IBD). However, their precise mechanisms remain unclear. Interactions between the gut microbiota and enteric glial cells (EGCs) ...
SGK1 signaling: an important modulator of CFTR function and early immune response in mouse intestine [0.03%]
SGK1信号转导：调控小肠CFTR功能和早期免疫反应的重要调节因子
Caroline Muiler,Anderson Santos,Nadia A Ameen
Caroline Muiler
Glucocorticoid (GC) and stress-induced SGK1 signaling rapidly modulate intestinal epithelial transport, yet whether epithelial SGK1 is required to couple GC signaling to functional CFTR output in vivo has remained unclear. We examined this ...
Sex-Specific Differences in Liver DNA Methylation Patterns and Epigenetic Aging in Mice [0.03%]
小鼠肝脏DNA甲基化模式及表观遗传老化的性别差异
Shant Apelian,Ramanaiah Mamillapalli,Abdullah Ucar et al.
Shant Apelian et al.
Background: Biological sex has been shown to influence aging outcomes, contributing to distinct trajectories in disease susceptibility and lifespan. DNA methylation patterns provide a quantitative measure of biological aging. This study inv...
Tools and Advanced Imaging Technologies for Assessing Intestinal Epithelial Barrier Integrity: A Systematic Review [0.03%]
评估肠上皮屏障完整性的工具和高级成像技术：系统性综述
Sophie Vieujean,Raja Atreya,Andrea Buda et al.
Sophie Vieujean et al.
The intestinal epithelium is a key component of the intestinal barrier, which is the largest and most complex barrier of the human body, regulating nutrients absorption while restricting the entry of harmful antigens. Breakdown of this barr...
WNT3a Induces External Anal Sphincter Fibrosis and Dysfunction in Rabbits [0.03%]
WNT3a诱导兔外肛门括约肌纤维化及功能障碍
Jagadeesh Thippeswamy,Merlin Mamachan,Jennifer Shin et al.
Jagadeesh Thippeswamy et al.
Injury and aging of the external anal sphincter (EAS) muscle lead to fibrosis and muscle dysfunction, major contributors to fecal incontinence. Activation of the WNT/β-catenin signaling pathway has been linked to fibrosis in various tissue...
Brown Adipose Tissue Inactivation Exacerbates Alcohol-Induced Liver Steatosis, Inflammation, and Fibrosis [0.03%]
棕色脂肪组织失活加重酒精引起的肝脂变、炎症和纤维化
Qing Zhang,Zhiguo Zhang,Liangyou Rui
Qing Zhang
Alcohol-induced liver fibrosis is a devastating manifestation of alcohol-related liver disease (ALD). However, conventional mouse models fail to recapitulate this fibrotic phenotype, limiting their translational relevance. Mice develop and ...
MrgprC11 Expression and Function in Vagal Afferent Nerves in the Esophagus [0.03%]
迷走神经食管化学感觉器中的MRGPRC11表达及其功能作用
Xiaoyun Yu,Yongming Huang,Mayur J Patil et al.
Xiaoyun Yu et al.
Noxious stimulation-induced esophageal nociception plays a crucial role in generating esophageal pain and heartburn, but the underlying mechanism remains unclear. MrgprC11 is a recently discovered member belonging to Mas1-related G protein-...
Esophageal Mucosal Mast Cell Density and Degranulation are Increased in Gastro-esophageal Reflux Disease [0.03%]
胃食管反流病患者的食道粘膜肥大细胞密度和脱颗粒作用增强
Tom Leech,Madusha Peiris
Tom Leech
Introduction: Gastro-esophageal reflux disease (GERD) is a chronic condition encompassing visceral pain - experienced as heartburn and, in some cases, inflammation of the esophageal mucosa. Although mast cell dysregulation has been describe...
New Approach Methodologies in Crohn's Disease Link Molecular Disease Subtypes to Clinical Outcomes [0.03%]
新的克罗恩病亚型的临床结果联系分子疾病亚型的方法学研究
Harrison M Penrose,Saptarshi Sinha,Courtney Tindle et al.
Harrison M Penrose et al.
Current clinical decision-making is hindered by the absence of predictive preclinical models that faithfully bridge molecular diversity to patient outcomes. Here, we apply the principle of abstraction-deriving essential features from human ...