Investigating Intestinal Farnesoid X Receptor functions at the Intestinal Mucosal Barrier and in the Intestinal Microbiota in a Biliary Obstruction Mouse Model [0.03%]
胆道梗阻小鼠模型中肠粘膜屏障和肠道微生物群中的肠法尼醇X受体功能研究
Yaoyao Cai,Xintong Chen,Hanfei Wang et al.
Yaoyao Cai et al.
Intestinal barrier dysfunction and dysbiosis are critical intestinal alterations in biliary obstructive diseases, for which FXR is a potential intestinal therapeutic target, but its roles and mechanisms in the intestinal tract remain poorly...
Glia maturation factor-β in hepatocytes enhances liver regeneration and mitigates steatosis and ballooning in zebrafish [0.03%]
glia母细胞衍生生长因子-β诱导的肝细胞增殖促进肝脏再生及缓解斑马鱼脂肪变性和气球样变损伤
Hong-Yu Li,Wei-Lan Zeng,Yi-Wen Ye et al.
Hong-Yu Li et al.
Glia maturation factor-β (Gmfb), an actin filament debrancher, was initially identified in brain and recently linked to liver diseases. To investigate the role of hepatocyte Gmfb (hep-Gmfb) in liver reparative regeneration, hepatocyte-spec...
Adolescent binge drinking disrupts hepatic lipid homeostasis leading to steatosis in rats: protective role of folic acid in cholesterol and fatty acid balance [0.03%]
青少年大量饮酒会破坏大鼠肝脏脂质稳态导致脂肪变性：叶酸在胆固醇及脂肪酸平衡中起保护作用
Maria Del Carmen Gallego Lopez,Fátima Nogales,Ines Romero Herrera et al.
Maria Del Carmen Gallego Lopez et al.
Alcohol liver damage (ALD) is increasing worldwide among adolescents, along with binge drinking (BD). BD is an acute alcohol consumption pattern, strongly pro-oxidant in the liver, and may be associated with steatosis, the first step in ALD...
Integrating Anorectal Manometry, Balloon Expulsion and Defecography: Insights into Diagnosing Pelvic Floor Dysfunction [0.03%]
排粪门腔测压、充盈试验和造影检查的联合应用在盆底功能障碍性疾病的诊断价值
Narmin Zoabi,Dorit Zelikovich,Fahim Kanani et al.
Narmin Zoabi et al.
Introduction: Defecatory dysfunction (DD) is a common cause of chronic constipation resulting from functional abnormalities or structural pelvic pathologies. Accurate diagnosis requires combining anorectal manometry (ARM), balloon expulsion...
Farnesoid X receptor inhibits proinflammatory cytokine-induced epithelial necroptosis in vitro: implications for preservation of intestinal barrier function [0.03%]
法尼醇X受体通过抑制细胞坏死性凋亡来维持体外上皮屏障功能：对体内炎症反应的启示
Caitriona E Curley,Natalia K Lajczak-McGinley,Luciano Adorini et al.
Caitriona E Curley et al.
Background: Epithelial cell death and compromised barrier function are key features of inflammatory bowel disease (IBD) pathogenesis. Previous studies suggest the nuclear bile acid receptor, farnesoid X receptor (FXR), to promote intestinal...
Inhibition of SREBP-1c Rescues Hepatic CYP7B1 Expression and Bile Acid Synthesis in Malnourished Mice [0.03%]
抑制SREBP-1c可缓解营养不良小鼠的肝CYP7B1表达及胆汁酸合成障碍
Xioyang Wan,Krishnakant G Soni,Jong Min Choi et al.
Xioyang Wan et al.
Malnutrition decreases intestinal bile acids, resulting in inefficient nutrient absorption and impaired catch-up growth. Mechanisms by which bile acid depletion occurs in malnutrition are unknown. Using a mouse model of early-life malnutrit...
Lactiplantibacillus Plantarum strengthens the intestinal barrier: involvement of the endocannabinoidome [0.03%]
乳植链菌植物亚种增强肠道屏障：内源大麻素系统的作用
Bénédicte Allam-Ndoul,Elena Cristina Pulido Mateos,Frédéric Bégin et al.
Bénédicte Allam-Ndoul et al.
Probiotics have been suggested to ameliorate intestinal epithelial homeostasis and barrier function. They also modulate several mediators and receptors of the expanded endocannabinoid system, or endocannabinoidome (eCBome), potentially expl...