Low-Dose Galactose Rebalances HBP-mTORC1-SREBP-1c Signaling to Suppress Hepatic Lipogenesis and Protect Against Early-Stage Alcohol-Related Liver Disease [0.03%]
低剂量半乳糖通过重新平衡HBP-mTORC1-SREBP-1c信号通路来抑制肝脂质合成并对抗酒精相关性早期肝脏疾病
Yanhui Li,Rui Guo,Yanyu Qian et al.
Yanhui Li et al.
Overactivation of hepatic de novo lipogenesis (DNL) contributes to fatty liver disease. While glucose and fructose strongly promote DNL, diary-rich galactose is only weakly lipogenic. However, whether and how it regulates hepatic DNL remain...
Role of serine/threonine phosphatases 1 and 2A in pancreatic acinar fluid and electrolyte secretion [0.03%]
蛋白磷酸酶1和2A在胰腺外分泌中的作用
Irene Ramos-Álvarez,Samuel A Mantey,Robert T Jensen
Irene Ramos-Álvarez
Serine/threonine phosphatases 1 and 2A (PP1 and PP2A) play important roles in mediating cellular signaling in different tissues to different stimuli, including in protein synthesis, growth, cell cycle regulation and secretion. However, thei...
Loss of Histone Deacetylase 4 in Hepatocytes Perturbs Lipid Metabolism and Insulin Signaling in Diet-Induced Obesity Mice [0.03%]
肝细胞组蛋白去乙酰化酶4丢失通过饮食诱导肥胖小鼠脂质代谢和胰岛素信号通路失调
Hyungryun Jang,Minkyung Bae,Yoojin Lee et al.
Hyungryun Jang et al.
Epigenetic regulations link environmental factors to the development of obesity and metabolic dysfunction-associated steatotic liver disease (MASLD). We determined the role of hepatocyte histone deacetylase 4 (HDAC4) in the pathogenesis of ...
Disruption of gastrointestinal pdgfrα+ cells leads to loss of post-junctional inhibitory motor responses [0.03%]
肠胃肠PDGFRα细胞受损导致节后抑制性运动反应丧失
Sung Jin Hwang,Kenton M Sanders,Sean Ward
Sung Jin Hwang
Fibroblast-like cells (FLCs) exist in the smooth muscle layers of visceral organs, yet in many instances their functional role(s) have not been identified. FLCs express platelet-derived growth factor receptor (PDGFR) α and are a novel clas...
Clément de-Loubens,Edoardo Capuano,Claude Loverdo et al.
Clément de-Loubens et al.
HNF4A intestinal ablation positively influences the fate of ileal goblet cells during Salmonella Typhimurium infection [0.03%]
肠HNF4A缺失可改善回肠杯状细胞在感染Salmonella Typhimurium过程中的命运分布
Dianne Pupo Gómez,Vilcy Reyes Nicolás,Gisela Cofino Marrero et al.
Dianne Pupo Gómez et al.
Hepatocyte nuclear factor 4A (HNF4A) is a transcription factor that regulates a diverse range of intestinal epithelial genes involved in tissue renewal, differentiation, and metabolism, among other functions. The HNF4A locus is associated w...
The secondary bile acid, lithocholic acid, inhibits cystic fibrosis transmembrane conductance regulator expression and activity in colonic epithelial cells [0.03%]
脱氧胆酸通过抑制囊性纤维化跨膜转导调节器的表达和活性来抑制结肠上皮细胞的功能
Caitriona E Curley,Claire L Mobbs,Magdalena S Mroz et al.
Caitriona E Curley et al.
Introduction: Classically known for their roles in facilitating lipid digestion and absorption, bile acids are now also appreciated as enterocrine hormones that modulate many aspects of intestinal physiology. We have previously shown lithoc...
Andrea Geisz-Fremy
Andrea Geisz-Fremy
Pancreatitis is an inflammatory disorder of the pancreas that occurs in acute, recurrent acute and chronic forms, often leading to severe complications and long-term functional impairment. The disease develops through multiple pathological ...
Neurometabolic adaptations to intestinal inflammation in a mouse model of colitis [0.03%]
肠炎小鼠模型中的神经代谢适应性改变
Aurora D&#x;Alessio,Fabrizio M Liguori,Marius Alexander Wenzel et al.
Aurora D&#x;Alessio et al.
The inflammatory process is a conserved and adaptive biological response to infection or tissue damage. Despite its substantial energy demands, inflammation triggers centrally regulated changes in behavior, commonly referred to as sickness ...
Enteric glia, neuropeptides, and Parkinson's: impacts of calcitonin gene related peptide on gut alpha synuclein [0.03%]
肠胶质细胞，神经肽和帕金森病：降钙素基因相关肽对肠道α-突触核蛋白的影响
Hayley N Templeton,Toby B Lanser,Stuart A Tobet et al.
Hayley N Templeton et al.
Parkinson's Disease is a neurodegenerative disorder pathologically characterized by accumulation of misfolded α-synuclein in the central and peripheral nervous systems, influencing symptomology at both sites. Calcitonin gene-related peptid...