Effects of propofol and sevoflurane anesthesia on renal blood flow and oxygenation during major hemorrhage in pigs [0.03%]
异丙酚和七氟醚麻醉对大出血猪肾血流及氧合的影响
Robert Frithiof,Micael Taavo,Arash Emami et al.
Robert Frithiof et al.
Hemorrhage and hypotension leading to renal hypoperfusion are common causes of acute kidney injury (AKI). Anesthetic agents may affect renal hemodynamics, potentially altering renal outcomes during hypovolemia. This study evaluated the effe...
Dietary K+ supplementation restores normal aldosterone level in Na+-deprived renal tubule-specific CAP1/Prss8-deficient mice [0.03%]
膳食补钾可恢复钠缺乏小鼠肾小管特异性CAP1 / Prss8基因敲除所致的醛固酮水平失调现象
Elodie Ehret,Muriel Auberson,Dongmei Wang et al.
Elodie Ehret et al.
We previously reported that Na+-deprived mice lacking CAP1/Prss8 in kidney tubules maintained ENaC-mediated sodium balance albeit persistent hypoaldosteronism, hence indicating an uncoupling from aldosterone production. This further suggest...
SerpinE2 deficiency exacerbates glomerular Injury in diabetic nephropathy through dysregulated angiogenesis and inflammatory responses [0.03%]
丝裂酶抑制剂E2缺乏通过血管生成和炎症反应紊乱加剧糖尿病肾病的肾小球损伤
Leila Idir,Junjie Yu,Philippe Bonnin et al.
Leila Idir et al.
Diabetic nephropathy (DN) is a multifactorial disease in which inflammation and angiogenesis play a crucial role. SerpinE2, or protease nexin-1 (PN-1), is a protease inhibitor of the serpin family, expressed by vascular and inflammatory cel...
Exogenous Uromodulin and Tubular Responses in a Model of Oxalate-Induced Kidney Injury [0.03%]
外源性尿徽蛋白和草酸诱导的肾脏损伤模型中的肾小管反应
Larissa de Araújo,Neydiana Pina-Lopes,Beatriz Costa Silvestre Pereira et al.
Larissa de Araújo et al.
Crystalline nephropathies are associated with kidney injury. Uromodulin (Umod), a glycoprotein produced in the kidneys, regulates salt transport, protecting against urinary tract infections, kidney stones, and kidney injury, contributing to...
The nuclear export inhibitor selinexor improves kidney function in a rat model of focal segmental glomerulosclerosis [0.03%]
核出口抑制剂塞利尼索可改善 focal segmental glomerulosclerosis 小鼠模型的肾功能
Yingying Gao,Mohamed Hamed,Ina Verena Martin et al.
Yingying Gao et al.
Focal segmental glomerulosclerosis (FSGS) is a common glomerular pathology characterized by podocyte injury, which can lead to kidney failure. Among the factors contributing to podocyte damage are mutations in nuclear pore complexes (NPCs),...
The organelle tethering protein PDZD8 regulates endolysosomal maturation and TLR9-NF-κB signaling in cisplatin-induced acute kidney injury [0.03%]
PDZD8分子夹蛋白通过调节内吞体溶酶体成熟和TLR9-NF-κB信号转导参与顺铂诱导的急性肾损伤
Yuto Takenaka,Hiroshi Maekawa,Yu Ah Hong et al.
Yuto Takenaka et al.
Acute kidney injury (AKI) is a life-threatening condition with high morbidity and mortality, characterized by inflammation linked to organelle stress. Despite its clinical significance, effective therapies remain limited. While organelle dy...
Fatty Acids and Albumin are Transported by Distinct Mechanisms in the Proximal Tubule [0.03%]
脂肪酸和白蛋白通过不同的机制在近端小管中转运
Nestor H Garcia,Robert J Gaivin,Shenaz Khan et al.
Nestor H Garcia et al.
Under physiologic conditions, proximal tubules depend on basolateral fatty acid (FA) uptake for metabolism. In pathophysiologic conditions due to glomerular filtration barrier disruption, albumin-bound FA undergo filtration and proximal tub...
KCC3 is not required for the distal convoluted tubule response to reduced dietary potassium intake [0.03%]
KCC3不是远端小管对低钾饮食反应所必需的
Masa-Ki Inoue,Alina Yu,Mohammed Zubaerul Ferdaus et al.
Masa-Ki Inoue et al.
The distal convoluted tubule (DCT) plays a crucial role in potassium (K⁺) homeostasis, with electrogenic basolateral K⁺ flux well established as a regulator of its function. While the involvement of electroneutral basolateral K⁺ transpor...
Role of Intestinal Claudin-2 in Calcium Permeability and Whole-Body Calcium Balance [0.03%]
肠胞Claudin-2在钙通透性和全身钙平衡中的作用
Duuamene Nyimanu,Christine Behm,Alan S L Yu
Duuamene Nyimanu
Kidney stone disease is characterized by hypercalciuria and intestinal hyperabsorption of calcium, leading to the formation of calcium crystals in the kidney. Claudin-2 is a tight junction protein that forms paracellular cation pores, and m...