Chronic circadian stress impairs blood pressure and sodium homeostasis in a diet- and sex-specific manner [0.03%]
慢性昼夜节律压力以饮食和性别特定的方式损害血压和钠稳态
Mary N Latimer,Megan K Rhoads,Lance Dylan Reynolds et al.
Mary N Latimer et al.
This study investigates the effects of environmental circadian disruption and high-fat diet (HFD) on cardiovascular and renal functions in Bmal1 knockout (KO) and wild-type (WT) rats. Under 12:12 light:dark conditions, Bmal1 KO males and fe...
ENDOTHELIAL DYSFUNCTION ACCELERATES AKI TO CKD TRANSITION BY PROMOTING β-CATENIN ACTIVATION IN MACROPHAGES [0.03%]
内皮功能障碍通过促进巨噬细胞中β-catenin活化来加速AKI向CKD的转变
Masanobu Takasu,Seiji Kishi,Hajime Nagasu et al.
Masanobu Takasu et al.
Acute kidney injury (AKI) frequently progresses to chronic kidney disease (CKD), resulting in long-term renal dysfunction. While traditional risk factors such as hypertension, diabetes, and aging contribute to this transition, endothelial d...
SGLT-2 inhibitors attenuate pattern recognition molecules collectin kidney 1 and mannose-binding lectin in kidney and liver in mice with diabetes [0.03%]
糖尿病小鼠中钠葡萄糖协同转运蛋白-2抑制剂可减轻模式识别分子collectin肾素1和甘露聚糖结合凝集素在肾脏和肝脏中的聚集作用
Mia Jensen,Steffen Thiel,Søren W K Hansen et al.
Mia Jensen et al.
Background: SGLT-2 inhibitors improve outcomes in diabetic nephropathy (DN) and cardiovascular disease. To elucidate the underlying protective mechanisms, we explored the hypothesis that the lectin complement pathway, specifically through c...
AutoGlom: Software Tool for Segmentation and Analysis of Magnetic Resonance Images of the Kidney [0.03%]
自动分割和分析肾脏磁共振图像的软件工具
Teng Li,Adam Cochran,Yanzhe Xu et al.
Teng Li et al.
Magnetic resonance imaging (MRI) is increasingly important in preclinical and clinical investigations of the kidney. However, there are few user-friendly, flexible, and standardized tools for evaluating MR images for quantitative imaging an...
Iron Metabolism and Ferroptosis: Druggable Targets to Delay the Progression of Lupus Nephritis [0.03%]
铁代谢与铁死亡：延缓 lupus nephritis 进展的药物治疗靶点
Leena Al-Hraki,Laurence Morel,Yogesh Scindia
Leena Al-Hraki
Lupus nephritis (LN) is the renal manifestation of the autoimmune diseases Systemic lupus erythematosus (SLE). LN is characterized by a dysregulated immune system, presence of autoantibodies and renal immune complex deposits which collectiv...
Macrophages and TGFB Signaling Regulate Fibrosis in the E. coli-Infected Mouse Prostate [0.03%]
大肠杆菌感染的小鼠前列腺纤维化受巨噬细胞和TGFB信号通路的调节
Brandon R Scharpf,Jaskiran Sandhu,Hannah Ruetten et al.
Brandon R Scharpf et al.
Prostate inflammation and fibrosis are linked to lower urinary tract symptoms (LUTS) in men. Uropathogenic Escherichia coli (E. coli) infection of the mouse prostate triggers a cascade of immune responses that drive inflammation and fibrosi...
Ad Libitum Drinking Does Not Mitigate Acute Kidney Injury Risk nor Elevations in Oxidative Stress or Inflammation during Simulated Occupational Heat Stress [0.03%]
随意饮水无法缓解模拟职业性热应激下的急性肾损伤风险及氧化应激或炎症反应的增加
Erica Tourula,M Jo Hite,Molly E Heikkinen et al.
Erica Tourula et al.
This study tested the hypothesis that ad libitum fluid intake during a two-hour occupational heat stress simulation attenuates increases in renal oxidative stress, inflammation, and acute kidney injury (AKI) risk compared to fluid restricti...
New insight into plasma and organelle membrane repair to guard against cell death in tubular epithelium after acute kidney injury [0.03%]
急性肾损伤后管状上皮细胞血浆和细胞器膜修复新机制保障细胞存活
Si-Meng Wang,Ning Li,Wei-Wei Qian et al.
Si-Meng Wang et al.
Plasma membrane repair is crucial for resealing membrane disruptions from physiological and pathological stimuli to preserve cell integrity and homeostasis. Tubular epithelial cells (TECs) die of unrepaired membrane injury induced by bioche...
Spleen tyrosine kinase signaling in myeloid cells promotes macrophage infiltration, glomerulosclerosis and interstitial fibrosis in diabetic kidney disease [0.03%]
髓系细胞中脾酪氨酸激酶信号促进糖尿病肾病中巨噬细胞浸润、肾小球硬化和间质纤维化
Xiu Xian Chia,Elyce Ozols,David J Nikolic-Paterson et al.
Xiu Xian Chia et al.
Macrophages have been implicated in causing renal injury in diabetic kidney disease (DKD). Spleen tyrosine kinase (Syk) plays an important role in signaling via a number of cell surface receptors that promote recruitment and activation of m...