Amanda J Clark,Brenda Mendoza Flores,Marie Christelle Saade et al.
Amanda J Clark et al.
Background: Acute Kidney Injury (AKI) is prevalent among hospitalized patients. Novel biomarkers are needed to diagnose AKI and target therapies. Endotrophin (ETP) is a molecule released during collagen type VI formation that may promote in...
Regional metabolic analysis of structurally preserved kidney slices by ex vivo respirometry [0.03%]
离体呼吸法检测结构保存的肾切片的区域代谢状况
Ryoichi Bessho,Olena Davidoff,Hanako Kobayashi et al.
Ryoichi Bessho et al.
A comprehensive spatial analysis of kidney metabolism is essential for advancing knowledge of both normal kidney physiology and pathophysiology. The kidney exhibits marked regional differences in bioenergetic demands and substrate utilizati...
5-hydroxytryptamine 1F receptor loss reduces renal vasculature and prevents lasmiditan-induced recovery following moderate-severe acute kidney injury in mice [0.03%]
小鼠5-羟色胺1F受体丢失减少肾血管并防止在中重度急性肾脏损伤后lasmiditan诱导的恢复
Austin D Thompson,Kai W McAlister,Natalie E Scholpa et al.
Austin D Thompson et al.
Kidney disease (KD) has emerged as a major global health crisis and leading cause of morbidity and mortality worldwide, impacting over 850 million individuals. Pathophysiological hallmarks of KD encompass renal tubular cell injury/necrosis,...
Pregnane X receptor (PXR) increases urine concentration by upregulating hypothalamic arginine vasopressin expression [0.03%]
孕烷X受体(PXR)通过上调下丘脑血管加压素表达来增加尿液浓缩能力
Xiaowan Sun,Ruifen Li,Zhilin Luan et al.
Xiaowan Sun et al.
The pregnane X receptor (PXR) is a ligand-activated transcription factor and a member of the nuclear receptor superfamily. PXR is constitutively expressed in the hypothalamus and kidney, with its physiological function incompletely understo...
Shaza Khan,Lihe Chen,Chung-Lin Chou et al.
Shaza Khan et al.
Arginine vasopressin (AVP) is a peptide hormone synthesized in the hypothalamus and secreted by the posterior pituitary. Previous studies toward understanding of AVP physiology relied heavily on Brattleboro rats, which have a spontaneous mu...
Decreased parietal epithelial cell density is linked to podocyte depletion and predictors of kidney disease progression in human kidneys [0.03%]
视网膜上皮细胞密度降低与人肾脏系膜增生和肾病进展预测因素有关
Jenna T Ference-Salo,Christopher L O&#x;Connor,Rajasree Menon et al.
Jenna T Ference-Salo et al.
Parietal epithelial cells (PECs) have been implicated in the pathogenesis of glomerulosclerosis in rodent models, and novel technologies are beginning to unravel their contributions to human glomerular disease. Here we report the developmen...
Madison Williams,Brooke O&#x;Donnell,Linda Columbus et al.
Madison Williams et al.
Renal dysfunction leads to critical health conditions, including acute kidney injury (AKI) and chronic kidney disease (CKD), and is a driver of hypertension. Despite their global prevalence and impact, the pathophysiology for all kidney dis...
The non-steroidal MR antagonist Finerenone reverses Western diet-induced kidney disease by regulating mitochondrial and lipid metabolism and inflammation [0.03%]
非甾体MR拮抗剂Finerenone通过调节线粒体和脂质代谢及炎症逆转西方饮食引起的肾脏疾病
Komuraiah Myakala,Xiaoxin X Wang,Nataliia Shults et al.
Komuraiah Myakala et al.
Mineralocorticoid receptor (MR) overactivation plays a crucial role in the pathogenesis of chronic kidney disease, as well as several cardiovascular and arterial diseases. Current studies determined the mechanisms of the beneficial kidney e...
Jessica A Dominguez Rieg,Louise Nyrup Odgaard,Jianxiang Xue et al.
Jessica A Dominguez Rieg et al.
Transport across cells of the renal tubule differs between females and males, possibly as a consequence of varying abundance of transport proteins along the nephron. We hypothesized that sex-specific differences in the physiological respons...