Sex Differences in Urinary Extracellular Vesicles Originating from the Genitourinary System in Health and Disease [0.03%]
健康与疾病状态下泌尿生殖系统来源的尿液胞外囊泡性别差异分析
Priyadarshini Pantham,Elina Aleksejeva-Zagura,Karina Barreiro et al.
Priyadarshini Pantham et al.
Urinary extracellular vesicles (uEVs) have risen to the forefront as a source of biomarkers in urine, a biofluid that can be obtained non-invasively in large quantities. These lipid bilayer-bound, anucleate particles contain molecular cargo...
Delayed conception or sildenafil prevents endothelial dysfunction in pregnant rats after renal ischemia-reperfusion [0.03%]
延迟妊娠或使用西地那非预防肾缺血再灌注后怀孕大鼠内皮功能障碍
Desmond Moronge,Victor Ayulo,Elisabeth Mellott et al.
Desmond Moronge et al.
Nearly half of AKI patients are female and the incidence is rising. Pregnant women with a history of AKI experience disproportionately high adverse pregnancy outcomes even after clinical measures suggest renal recovery. Many adverse outcome...
Excessive protein uptake by endocytic receptors causes elevated proliferation and senescence in proximal tubules primarily in outer medulla of proteinuric mice [0.03%]
蛋白尿小鼠近端小管区室主要在外髓质部位通过内吞受体过量摄入蛋白质导致细胞增殖和衰老
Yoshifumi Kurosaki,Fumitaka Kawakami,Akemi Imoto et al.
Yoshifumi Kurosaki et al.
Proteinuria contributes to the progression of chronic kidney disease and causes protein overload in proximal tubular epithelial cells (PTECs), fibrosis and inflammation. While protein overload is suggested to stimulate PTEC proliferation, i...
Caloric Restriction Decreases Autoimmune Disease Activity and Lowers Blood Pressure in an Experimental Model of Systemic Lupus Erythematosus [0.03%]
热量限制可减轻系统性红斑狼疮小鼠模型自身免疫病的活动并降低血压
Jordan A Rhymes,Luciano D Mendoza,Jayla D Sandifer et al.
Jordan A Rhymes et al.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that occurs more frequently and in women and is associated with an increased risk of renal injury and hypertension. Studies have shown that obesity is associated with greate...
Smartwatches in the digital health ecosystem for health monitoring in patients with chronic kidney disease and kidney failure: opportunities and challenges [0.03%]
智能手表在慢性肾脏病和肾衰竭患者健康监测的数字生态系统中的机遇与挑战
Jeroen P Kooman,Maggie Han,Sabine Josemans et al.
Jeroen P Kooman et al.
Smartwatches are widely used by the general population as tools to promote wellness. Modern smartwatches can monitor arterial oxygen saturation, blood pressure, heart rate, arrhythmias, physical activity, sleep patterns, falls and body comp...
Metabolomics in renal cystic disease: links to mechanisms and identification of pathways for potential pre-diagnosis [0.03%]
代谢组学在肾囊性疾病中的应用：与机制的关系及潜在诊断前标志物的识别路径
Liyan Chen,David Broadhurst,Armaghan Shafaei et al.
Liyan Chen et al.
Polycystic kidney disease (PKD) is a common hereditary kidney disorder with an insidious onset and complex mechanisms, making early diagnosis challenging. Current diagnostic methods, including imaging and genetic testing, have limitations. ...
Loss of Fn14 reduces cisplatin-induced maladaptive inflammatory and fibrotic gene expression and limits downstream tubular damage [0.03%]
Fn14丢失减少顺铂诱导的不适应性炎症和纤维化基因表达并限制下游肾小管损伤
Ross K Villiger,Katie C Y Lee,Malia H Harrison-Chau et al.
Ross K Villiger et al.
Persistent and repeated damage contribute to chronic kidney disease (CKD) progression, with repair responses diverging between successful resolution and failed repair. In the transition towards failed repair, renal tubules develop a maladap...
A previously uncharacterized R881S variant of transporter NBCe1 exhibits intracellular retention and virtually no plasma membrane expression [0.03%]
一个新的未表征的R881S变异型转运体NBCe1表现出向胞质留存和几乎无细胞膜表达的现象
Osamu Yamazaki,Hina Sato,Wataru Fujii et al.
Osamu Yamazaki et al.
Mutations in the Na+/HCO3- cotransporter NBCe1 (SLC4A4) cause proximal renal tubular acidosis (pRTA) and extrarenal symptoms including glaucoma, band kelatopathy, migraine, growth disorder, and abnormal tooth enamel. From NCBI dbSNP databas...
Abnormal activation of the mineralocorticoid receptor in the aldosterone-sensitive distal nephron contributes to fructose-induced salt-sensitive hypertension [0.03%]
醛固酮敏感远端肾单位中矿化固醇受体的异常活化可导致果糖诱导的盐敏感性高血压
Ronghao Zhang,Najeong Kim,Shujie Shi et al.
Ronghao Zhang et al.
Fructose high-salt (FHS) diets increase blood pressure (BP). The mineralocorticoid receptor (MR), regulates Na+ reabsorption by the aldosterone-sensitive distal nephron (ASDN). The MR can be transactivated by glucocorticoids, including thos...
A global vision for the future: Introducing the new editorial team of AJP-Renal [0.03%]
展望未来：AJP-Renal 新编辑部亮相
János Peti-Peterdi
János Peti-Peterdi