The urine metabolomic signature of distal diuretics and diuretic-induced hyponatremia in patients with chronic kidney disease [0.03%]
慢性肾脏病患者远端利尿剂的尿代谢标志物及利尿剂所致低钠血症的尿代谢标志物
Crissy F Rudolphi,Usha Musterd-Bhaggoe,George J G Ruijter et al.
Crissy F Rudolphi et al.
Recent clinical trials have shown that distal nephron-acting diuretics are effective in managing fluid retention and salt-sensitive hypertension in people with chronic kidney disease (CKD). However, their use may be complicated by diuretic-...
Peak Oxygen Consumption is Positively Associated with Estimates of Oxygen Extraction and Microvascular Blood Volume in Veterans with Chronic Kidney Disease [0.03%]
慢性肾脏病患者峰值耗氧量与氧气摄取估计值和微血管血容量之间的正相关性研究
Jared M Gollie,Peter Kokkinos,Samir S Patel et al.
Jared M Gollie et al.
Peak oxygen consumption (V̇O2peak) is reduced in patients with chronic kidney disease (CKD). Although cardiovascular and skeletal muscle factors are implicated in the declines of VO2peak, few studies have evaluated muscle oxygenation respo...
Lawrence G Palmer,Alan M Weinstein,Gustavo Frindt
Lawrence G Palmer
Among the many impressive feats of the kidney is the ability to conserve Na+. When intake of Na+ through the diet is very low, urine Na+ concentrations can fall to sub-millimolar levels. This enables the preservation of extracellular fluid ...
GPR183 contributes to renal macrophage infiltration and fibrosis in kidney injury [0.03%]
GPR183参与肾损伤中的肾巨噬细胞浸润和纤维化
Qian Zhang,Yan Wang,Yu Fan et al.
Qian Zhang et al.
Macrophages play a key role in kidney inflammation and fibrosis. The oxysterol receptor G protein-coupled receptor 183 (GPR183) is an important immunomodulatory receptor, but its role in kidney disease is undefined. In this study, we invest...
NBL1 Associates with Renal Phenotypes in Mice, but Partial Nbl1 Reduction Does Not Ameliorate Kidney Disease [0.03%]
NBL1与小鼠的肾脏表型相关，但部分降低Nbl1并不能改善肾病
Courtney N Willey,Rei Bufi,Yuka Takemon et al.
Courtney N Willey et al.
Increased concentrations of neuroblastoma suppressor of tumorigenicity 1 (NBL1) in the blood have been associated with disease progression in diabetic kidney disease and IgA nephropathy. However, it is unclear whether NBL1 is a causal facto...
Deletion of Cab39 adaptors results in KS-WNK1 independent accumulation of SPAK in biomolecular condensates [0.03%]
缺少Cab39适配体可导致KS-WNK1非依赖性SPAK在生物分子凝聚体中的积累
Mohammed Zubaerul Ferdaus,Masa-Ki Inoue,Andrew S Terker et al.
Mohammed Zubaerul Ferdaus et al.
The sodium-chloride cotransporter (NCC) in the distal convoluted tubule regulates renal sodium reabsorption, potassium homeostasis, and blood pressure. NCC phosphorylation is controlled by extracellular potassium via the WNK-SPAK kinase cas...
Therapeutic effects of imidazoline 2 receptor activation on lower urinary tract dysfunction in a mouse model of spinal cord injury [0.03%]
咪唑啉-2受体激活对脊髓损伤小鼠下尿路功能障碍的治疗作用研究
Mamoru Hashimoto,Sergei Karnup,Stephanie L Daugherty et al.
Mamoru Hashimoto et al.
Background: This study evaluated the effects of the imidazoline I2 receptor (I2R) agonist 2BFI on lower urinary tract dysfunction (LUTD) in a mouse spinal cord injury (SCI) model. ...
Miguel A Gutiérrez-Gallardo,Jessica Paola Bahena-Lopez,David H Ellison et al.
Miguel A Gutiérrez-Gallardo et al.
The Calcium-sensing receptor (CaSR) is a central regulator of renal mineral homeostasis and tubular function. Since the discovery of its expression in the kidney, numerous studies have demonstrated that its actions are finely distributed al...
Stimulation of basolateral calcium-sensing receptor (CaSR) inhibits Kir4.1/Kir5.1 in the mouse distal convoluted tubule [0.03%]
刺激基底外侧钙敏感受体(CaSR)抑制小鼠远曲小管中的Kir4.1/Kir5.1
Junlin Wang,Jiawen Zhang,Shumin Kong et al.
Junlin Wang et al.
The calcium-sensing-receptor (CaSR) is expressed in the basolateral membrane of distal- convoluted-tubule (DCT) and CaSR expression inhibited Kir4.1 in cells expressing Kcnj10. The aim of the study is to explore whether CaSR inhibits Kir4.1...
Increasing Plasma Sodium with Tolvaptan Under Regulated Water Intake: Comparison with Hypertonic Saline [0.03%]
在控制饮水条件下用托伐普坦升高血浆钠与高张盐水比较
Nabil William Sweis,Jennifer Tuazon,Yusra Cheema et al.
Nabil William Sweis et al.
Background: In the treatment of hyponatremia, there is a potential risk of osmotic demyelination due to an excessively rapid rise in plasma sodium. We reasoned that a controlled rate of sodium increase could be achieved using a vasopressin ...