Luminescence Turn-on of Lanthanide Coordination Polymers Triggered by Norfloxacin for Visual Detection and Anti-Counterfeiting [0.03%]
受诺氟沙星分子触发的镧系金属有机多面体的发光增强及其在检测与防伪中的应用
Jiaying Chen,Peng Liu,Weifei Wang et al.
Jiaying Chen et al.
Norfloxacin (NOR) has raised growing concerns over food safety and environmental sustainability due to its persistence and bioaccumulation. The luminescence turn-on effect induced by NOR offers a promising approach for the development of ad...
Modulation of Plasmon Damping and Fluorescence Activity in Dumbbell-Shaped Gold Nanorods Decorated with Platinum Islands via Thiolated β-Cyclodextrin-Based Host-Guest Chemistry [0.03%]
基于主客体化学的硫醇化β-环糊精调节哑铃形金纳米棒的等离激元损耗和荧光性能及表面Pt岛分布的研究
Metya Indah Firmanti,Mukunthan Ramasamy,Ji Won Ha
Metya Indah Firmanti
Bimetallic gold nanorods decorated with platinum islands (AuNRs@Pt) are widely recognized as promising photothermal agents due to their localized surface plasmon resonance (LSPR) effects, which enable localized heat generation for photother...
Cell Permeability and Target Engagement of Middle-Sized Molecules Quantified by In-Cell NMR [0.03%]
通过细胞内NMR量化中等大小分子的细胞通透性和靶点参与程度
Yota Sukigara,Hajime Kamoshida,Yuji Tokunaga et al.
Yota Sukigara et al.
Middle-sized molecules, such as macrocycles and cyclic peptides, are gaining attention as novel drug modalities due to their ability to permeate into cells and interfere with intracellular protein-protein interactions (PPIs). However, predi...
Deciphering Spatiotemporal Control of Ferroptosis in HCC: A Bifunctional Probe for Lipid Droplet Viscosity Dynamics and Interorganelle Communication [0.03%]
解密肝细胞癌铁死亡时空调控：一种双功能探针用于脂滴粘度动力学及细胞器间通讯研究
Tian Cheng,Chaomin Gao,Xueying Zheng et al.
Tian Cheng et al.
Although lipid droplets (LDs) are established as metabolic regulators of iron-dependent ferroptosis in hepatocellular carcinoma (HCC), their biophysical remodeling and spatiotemporal interactions with other organelles during this cell death...
Interfacial Charge Separation Engineering Enables Dual Small-Molecule Probe-Based Photoelectrochemical Multi-Enzyme Sensing [0.03%]
界面电荷分离工程使双小分子探针基光电解化学多酶检测成为可能
Jingyi Zhang,Ying Qin,Wenhong Yang et al.
Jingyi Zhang et al.
Photoelectrochemical (PEC) biosensors remain constrained in multianalyte detection due to inefficient charge separation and signal crosstalk. To address these challenges, we developed a dual small-molecule probe-modulated charge separation ...
Specific Lung-Targeting Shortwave Infrared Luminescence Nanoprobe: Precisely Delineating Sepsis-Induced Acute Lung Injury [0.03%]
特定肺靶向短波红外发光纳米探针：精准勾画脓毒症诱导的急性肺损伤影像学特征
Chenchen Li,Rui Huang,Kaijie Ma et al.
Chenchen Li et al.
Sepsis-induced acute lung injury (ALI), a life-threatening condition, necessitates a deeper molecular-level understanding to promote the development of therapeutic strategies. Although hydrogen sulfide (H2S) has been implicated in sepsis-as...
Increasing the Scale of the Mass Spectrometry Query Language Compendium with Explainable AI [0.03%]
基于可解释性人工智能的质谱查询语言数据库的构建及扩展
Thomas V Harwood,Mingxun Wang,Trent R Northen et al.
Thomas V Harwood et al.
A significant bottleneck in metabolomics data interpretation is the effective use of domain knowledge to assign structural information based on fragmentation patterns. The mass spectrometry query language (MassQL) aims to make this process ...
DNA Tetrahedral Sensors for Visualizing miR-21-Mediated Angiogenesis [0.03%]
用于可视化miR-21介导的血管生成的DNA四面体传感器
Shuhang Yin,Binbin Li,Boru Peng et al.
Shuhang Yin et al.
Angiogenesis is a critical driver of tumor metastasis, making it a key target for anticancer therapy. While oncogenic miR-21 has been identified as a key promoter of tumor angiogenesis through vascular endothelial growth factor (VEGF) regul...
In Situ Imaging of Extracellular Vesicles and Non-Alcoholic Fatty Liver Disease with a Near-Infrared Fluorescent Viscosity Probe [0.03%]
近红外荧光粘度探针在体成像外泌体及非酒精性脂肪肝疾病
Zhijie Li,Qianhua Li,Yijia Liu et al.
Zhijie Li et al.
Extracellular vesicles (EVs) have significant value in disease diagnosis. Non-alcoholic fatty liver disease (NAFLD) has become a global health issue, and real-time monitoring of NAFLD is crucial to prevent its further deterioration. However...
Oxygen-Tailored MoS2 as a High-Performance Substrate for Pressure-Induced Surface-Enhanced Raman Spectroscopy [0.03%]
氧调控的二硫化钼作为优异的压力促进型表面增强拉曼基底
Yongxue Chen,Yuling Yang,Zhenyu Wen et al.
Yongxue Chen et al.
Pressure-induced SERS (PI-SERS) has garnered increasing attention due to its applications in enhancing Raman signals under extreme conditions. However, the effective implementation of PI-SERS enhancement and the elucidation of its underlyin...