Construction of a Self-Enhanced Fluorescent Aptasensor Based on Lanthanide Ligand Self-Assembly and Catalytic Hairpin Assembly for Highly-Sensitive Detection of Anatoxin-a [0.03%]
基于镧系配合物自组装和发夹催化剂信号放大的高灵敏检测鱼体内藻毒素安托拉毒素-a的适配子传感器构建
Alina Bari,Guiying Jin,Yinbo Ban et al.
Alina Bari et al.
Anatoxin-a (ATX-a) is a potent neurotoxin produced by cyanobacteria, with growing evidence unequivocally linking it to acute aquatic toxicity, neurological impairment, and increased mortality in wildlife and livestock, highlighting its sign...
Reversible NIR Ratiometric Probe for Monitoring Redox Homeostasis in Lipid Droplets during Ferroptosis-Driven Liver Injury [0.03%]
一种可逆的NIR比例探针用于监测铁死亡诱导性肝损伤过程中脂滴中的氧化还原稳态
Songjiao Li,Min Deng,Ying Liu et al.
Songjiao Li et al.
Accurate diagnosis and timely treatment of drug-induced liver injury (DILI) are crucial to preventing progression to other liver diseases or failure. Cellular redox balance may be linked to DILI. Hypochlorous acid (HClO) and glutathione (GS...
Machine Learning-Enhanced Nanozyme Sensor Array for Accurate Multiple Quinolone Antibiotics Recognition [0.03%]
基于机器学习的纳米酶传感器阵列用于多种喹诺酮类抗生素的准确鉴别检测
Qihao Shi,Ziyuan Li,Yu Wang et al.
Qihao Shi et al.
The overuse of quinolone antibiotics (QNs) seriously endangers human health and the ecological environment. In this work, a copper dihydroxosulfate (Cu2(OH)2SO4) nanosheet exhibiting notable peroxidase-like (POD) and laccase-like (LAC) acti...
Bifunctional Block Polymer-Engineered Platinum Nanozymes for Ultrasensitive Immunoassay [0.03%]
双功能嵌段聚合物工程铂纳米酶用于超灵敏免疫测定法
Man Xu,Zhichao Yu,Shuqun Lao et al.
Man Xu et al.
This study presents a sensitive and facile strategy for dual modulation of the catalytic activity of nanozymes through surface ligand engineering and size effects. Four different capped polymers, including poly(vinyl acrylate) (PVA), polyvi...
Engineering the Interfacial Charge Transfer Dynamics by Plasmonic S-Scheme Heterojunctions for Machine-Learning-Assisted Dual-Mode Immunoassays [0.03%]
等离激元S型异质结工程化界面电荷转移动力学用于机器学习辅助的双模式免疫测定法
Zhen Yang,Jing Wang,Jiahui Zhao et al.
Zhen Yang et al.
The development of photoelectrochemical (PEC)-coupled dual-mode biosensors, combined with multivariate regression analysis, is pivotal for advancing point-of-care disease marker diagnostics. Herein, we present a machine learning (ML)-powere...
Advancing Microfluidic Photoelectrochemical Aptasensing Platform with Photogenerated Carrier Regulation for Protein Biosynthesis Inhibitors Detection [0.03%]
基于光生载流子调控的微流体光电化学生物传感平台研究及氨基酸蛋白合成抑制剂检测
Dongquan Leng,Lei Song,Yu Du et al.
Dongquan Leng et al.
Regulating the microscale carrier transport in semiconductor materials to enhance the macroscopic photoelectrochemical properties would drive technological advancement and industrial upgrading. In this work, we integrated the maturity of mi...
"Bio-inspired Nanoeye" Localizes Potentiated Antibody Binding Capacity for Driving Salmonella typhimurium Detection [0.03%]
“仿生纳米眼”增强抗体结合能力用于驱动沙门氏菌定位检测
Huilin Jia,Peiyu Lv,Meilin Wang et al.
Huilin Jia et al.
Salmonella enterica serovar typhimurium (S. typhimurium) is a ubiquitous foodborne bacterium that promises early diagnosis by lateral flow immunoassay (LFIA). To improve the sensitivity and selectivity of LFIA, the choice of nanomaterials a...
Chiral Discrimination of Organothiols via 19F NMR and a Multicomponent Reaction [0.03%]
手性识别有机硫化合物的氟核磁共振及多组分反应研究
Yilin Zeng,Jiajin Weng,Guangxing Gu et al.
Yilin Zeng et al.
This study aims to develop a sensitive and precise method for determining chiral thiols using an efficient multicomponent reaction. This innovative approach leverages the coupling of 19F-labeled chiral amines, o-phthalaldehyde, and targeted...
Engineering Dual-Mode-Responsive Probes for Real-Time HClO Monitoring in Drug-Induced Liver Injury [0.03%]
工程化双刺激响应型探针用于实时检测药物性肝损伤中的HOCl
Wenqiang Chen,Chi Zhang,Jingshuai Wang et al.
Wenqiang Chen et al.
Given the critical role of HClO in drug-induced liver injury (DILI), it is essential to establish an accurate and reliable technique for the in situ monitoring of its dynamic changes. Herein, by integrating a phenothiazinecoumarin and a leu...
Electron-Donating/Accepting Group Modulation Enhanced Fluorescent Sensing of Synthetic Cannabinoid JWH-018 via Through-Space Charge Transfer [0.03%]
基于分子内空间电荷转移的荧光团对合成大麻素JWH-018传感的研究及吸电子基团和给电子基团的调控作用
Yali Feng,Luyan Yang,Yingxing Li et al.
Yali Feng et al.
The substituent design and photophysical property manipulation are of paramount importance in fluorescent probe design, particularly crucial for chemically inactive molecules that lack reactive functional groups, such as synthetic cannabino...