Quantitative and Visual Detection of Pseudouridine at Specific Sites Using Bisulfite-Assisted Rolling Circle Amplification [0.03%]
Xiumin Liu,Jiehua Li,Xiaoyang Duan et al.
Xiumin Liu et al.
Pseudouridine (Ψ) is a prevalent RNA modification whose site-resolved quantification is critical for understanding epitranscriptomic regulation. We present pseU-SCOPE, a ligation-assisted rolling circle amplification (RCA) assay that conve...
Development of an Anti-Immunocomplex Antibody and Non-competitive Immunoassay for the Detection of Testosterone [0.03%]
Ida Bäckström,Urpo Lamminmäki,Etvi Juntunen et al.
Ida Bäckström et al.
Accurate and sensitive quantification of testosterone using simple, high-throughput, and low-cost methods has remained a longstanding analytical challenge, despite the issue being highlighted by the endocrinology community more than a decad...
Laser-Induced Graphite Multi-Ion Sensor for Real-Time Assessment of Fucoxanthin Therapy in Alcoholic Liver Disease [0.03%]
Xu Zhong,XiaoBo Liu,Bing Yin et al.
Xu Zhong et al.
Oxidative stress has been recognized as a pivotal mechanism for disrupting cellular ion homeostasis and contributes to the pathogenesis of associated conditions, including alcoholic liver disease (ALD). The real-time and accurate detection ...
Laser-Printed Electrochemical Microfluidic Aptasensing Chip for Simultaneous Detection of Multiple Pesticides [0.03%]
Xiaojuan Liu,Jiahui Zhao,Qinxing Sun et al.
Xiaojuan Liu et al.
Laser scribing-based nanotechnology shows superior performance in the precise and scalable construction of customized sensors. In light of the significant threats posed by pesticide residues to food safety and ecological sustainability, pro...
The New Scanning Mode in Digital Linear Ion Trap Mass Spectrometry for the Detection of New Psychoactive Substances in E-Cigarette Oils [0.03%]
新一代数字线性离子阱质谱扫描模式在电子烟油中新型精神活性物质检测中的应用研究
Sen Tian,Jiecong Lu,Yunjing Zhang et al.
Sen Tian et al.
The abuse of new psychoactive substances (NPS) has become a growing global concern, and their illegal addition to commercial e-cigarette oils poses severe threats to human health and potentially results in fatalities. Regulatory control of ...
Live-Cell Imaging and Lipidomics of Low-Density Lipoprotein Containing Intrinsically Fluorescent Cholesteryl Esters [0.03%]
含固有荧光胆固醇酯的低密度脂蛋白的活细胞成像和脂质组学研究
Alice Dupont Juhl,Richard R Sprenger,Maciej Modzel et al.
Alice Dupont Juhl et al.
Low-density lipoprotein (LDL) delivers cholesterol to mammalian cells in the form of cholesteryl esters (CEs), but due to the lack of suitable tools, our understanding of the intracellular transport and hydrolysis of CEs is limited. We pres...
Grayscale-Element Bayesian Method Based on Synchrotron Radiation Nano-CT: Quantitative Characterization of Elemental Content and Heterogeneity [0.03%]
基于同步辐射纳米CT的灰度元素Bayesian方法及其定量表征元素含量及异质性分布研究
Yichi Zhang,Fen Tao,Ruoyang Gao et al.
Yichi Zhang et al.
Achieving nondestructive, high-precision quantitative elemental analysis at the nanoscale has long been a challenge in materials characterization. The proposed Grayscale Bayesian Elemental Quantification Analysis (GBEQA) method effectively ...
Electrochemiluminescence Biosensor Based on Dual-Signal Regulation of Gold Nanoclusters for Amyloid-β Protein Detection [0.03%]
基于金纳米团簇双信号调控的电化学发光生物传感器检测淀粉样蛋白-Aβ
Qingfei He,Lingjun Cheng,Yuanyuan Yang et al.
Qingfei He et al.
Gold nanoclusters (AuNCs) are emerging electrochemiluminescence (ECL) emitters with unique luminescence and high stability. However, conventional AuNC-based ECL systems, which rely on single-signal regulation, often exhibit weak signal resp...
Nanofluidic Photoelectrochemical Biosensors for Ultrasensitive Detection of Prostate Cancer Biomarkers [0.03%]
用于超灵敏检测前列腺癌生物标志物的纳米流体光电化学生物传感器
Xudong Yang,Linge Chen,Yilong Wang et al.
Xudong Yang et al.
Significant advances have been made in nanofluidic biosensors for the highly efficient detection of disease biomarkers in complex biofluids. However, most research efforts have primarily focused on external voltage-driven sensing mechanisms...
Deconvolution of High-Dimensional Ion Mobility Data Using Reversible-Jump Markov Chain Monte Carlo [0.03%]
基于可逆跳跃马尔可夫链蒙特卡洛的高维离子淌度数据脱卷积
Jerome Riedel,Marc Safferthal,Gergo Peter Szekeres et al.
Jerome Riedel et al.
Deconvolution of multicomponent arrival time distributions is known to be a highly challenging task due to the "curse of dimensionality". Therefore, the development of a robust global optimizer is a crucial milestone in the automated analys...