Rapid Chiral Analysis of Drugs with Multiple Stereocenters via High-Resolution Ion Mobility [0.03%]
用于药物的多手性中心快速手性分析的高分辨率离子淌量法
Benjamin K Blakley,Jody C May,Valeria Guidolin et al.
Benjamin K Blakley et al.
The increasing structural complexity of small-molecule therapeutics requires sensitive analytical techniques that facilitate rapid chiral analysis of drugs with multiple chiral centers. Here, we demonstrate ultrafast chiral separations for ...
Quantifying Nanoplastics by Size: Bibliometric Insights and Advances in Separation Methods (2020-2026) [0.03%]
尺寸分级量化纳米塑料：2020-2026年文献计量学见解和分离方法进展
Zi Khang Chew,Fazira Ilyana Abdul Razak,Erma Fatiha Muhammad et al.
Zi Khang Chew et al.
Fluorescence Lifetime Imaging Microscopy Detects Preeclampsia, Gestational Diabetes Mellitus, and Their Comorbidity Early by Profiling Lipid Dysregulation [0.03%]
荧光寿命成像显微镜通过脂质紊乱谱分析早期检测子痫前期、妊娠糖尿病及其共病
Xiaoyu Zhang,Zhongqun Zhan,Xiaoyu Li et al.
Xiaoyu Zhang et al.
Preeclampsia (PE) and gestational diabetes mellitus (GDM) are common but complex pregnancy complications that often co-occur and lack reliable early diagnostic tools. This study introduces a fluorescence lifetime imaging microscopy (FLIM) b...
Energy-Decoupled Photoelectrochemical and Pressure Dual-Mode Biosensors for Machine-Learning-Assisted Immunoassay [0.03%]
基于机器学习的免疫检测的解耦光电器件和压力双模生物传感器
Jinxin Liu,Zhen Yang,Xingxing Meng et al.
Jinxin Liu et al.
Reliable and ultrasensitive detection of cardiac troponin I (cTnI) remains challenging due to the signal interference and limited self-validation capability of conventional biosensors. Herein, we report an orthogonal dual-mode biosensing st...
Laser Spectroscopic Sensing Based on an Integrated Piezoelectric Ceramic Acoustic Resonator and Tuning Fork [0.03%]
基于集成压电陶瓷声学谐振器和音叉的激光光谱检测技术
Botao Liu,Guowei Han,Ying He et al.
Botao Liu et al.
In this paper, a compact photoacoustic sensing architecture based on the integration of a piezoelectric ceramic acoustic resonator (PCAR) and a piezoelectric ceramic tuning fork (PCTF) is reported for the first time. Benefiting from the com...
DNA-Functionalized Covalent Organic Framework for Colorimetric Detection and Adsorption Removal of Uranyl Ions [0.03%]
用于铀离子比色检测及吸附去除的功能化DNA共价有机框架材料
Zhi-Hao Xue,Zhen-Wen Zhang,Qiang Shi et al.
Zhi-Hao Xue et al.
Inspired by the modulatable nanozymatic activity of covalent organic frameworks (COFs) by single-stranded DNA (ssDNA), herein, we developed a versatile platform for sensitive/specific colorimetric detection and efficient adsorption of UO22+...
Second Harmonic Nonlinear Warburg Admittance Analysis Eliminates Information Loss from Linearization in Traditional EIS: Theory and Experimental Validation [0.03%]
基于非线性Warburg admittance的二次谐波分析可消除传统EIS线性化带来的信息损失：理论与实验验证
Lauren A Frank,Jerome T Babauta,Daniel T Schwartz
Lauren A Frank
Low-frequency impedance or admittance experiments of reversible redox couples in well-supported quiescent electrolyte are normally analyzed using a linearized semi-infinite Warburg element with a single lumped parameter. Because each specie...
Rational Design of pH-Switches Based on Mismatch-Guided Hybridization of I-Motifs and G-Quadruplexes [0.03%]
基于错配引导的I- motif和G-四链体杂交的pH开关的理性设计
Pavel V Gabrusenok,Nina A Kasyanenko,Petr A Sokolov
Pavel V Gabrusenok
pH-responsive DNA nanodevices and materials are attracting wide attention owing to their promising applications in medicine and nanotechnology. However, the sustainable and systematic development of molecular pH-switches based on mismatch-g...
Nanoelectroanalysis with Carbon Nanopipettes Based on Prussian Blue-NiHCF for Hydrogen Peroxide Sensing [0.03%]
基于普鲁士蓝镍氢复合物的碳纳米探针用于过氧化氢检测的纳电分析学研究
Antonino Biagio Carbonaro,Gregorio Laucirica,Gastón A Crespo et al.
Antonino Biagio Carbonaro et al.
Carbon nanopipettes (CNPs) have emerged as powerful tools to track intracellular redox processes with high spatial resolution. Their implementation for robust H2O2 sensing, however, is still limited by stability and mechanistic constraints ...
Nonconjugated Alkyl Chains in Ionic Molecular Rotor Fluorophores: An Effective Modulating Moiety for Amyloid-β Probes [0.03%]
非共轭烷基链作为离子分子转子荧光团的有效调节基团及特异性淀粉样蛋白-β探针
Zhenyu Zhang,Junxin Yi,Zhang Lin et al.
Zhenyu Zhang et al.
Developing molecular structural tuning strategies for ionic molecular rotor (MR)-based β-amyloid (Aβ) fluorescent probes is essential for balancing high sensitivity, signal-to-background ratio (SBR) in wash-free mode, and blood-brain barr...