Core-Shell Bimetallic Nanozyme-Enabled Synergistic Photothermal-Electrochemical Amplification for Ultrasensitive Immunoassay [0.03%]
core-shell 双金属纳米酶增强型光热-电化学生物标志物超灵敏免疫检测法
Shuyun Chen,Yunsen Wang,Shuo Tian et al.
Shuyun Chen et al.
Colorimetric immunoassays based on the nanozymes offer amazing potentials in the fields of quick detection. However, the subjective nature of their visual interpretation, as well as the interference of ambient factors on color development f...
MALDI Mass Spectrometry Imaging of Metal Ions and Metabolites in Tissues Using a Bifunctional Matrix [0.03%]
一种双功能基质用于组织中金属离子和代谢物的基质辅助激光解析电离质量 spectrometry 成像技术
Ke Jia,Xiaochen Lu,Yidong Zhou et al.
Ke Jia et al.
Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is a powerful technique for spatially resolved analysis of diverse molecular species within biological tissues. However, the simultaneous imaging of metal ion...
Distinguishing Isomeric Caffeine Metabolites through Protomers and Tautomers Using Cryogenic Gas-Phase Infrared Spectroscopy [0.03%]
基于低温气相红外光谱的咖啡因代谢异构体的质子化同分异构体和互变异构体的区分研究
Niklas Geue,Gurpur Rakesh D Prabhu,Eleonora Renzi et al.
Niklas Geue et al.
Caffeine is metabolized through various pathways in the human body, with the primary two steps yielding isomeric products. Distinguishing these metabolites is crucial for mass spectrometry-based metabolomics, for example, to assess specific...
DNAzyme-Driven Dynamic Cycling Biosensor with Dynamic Fluorescent and Cumulative Electrochemiluminescence Monitoring of Single-Nucleotide Variants [0.03%]
动态荧光和累计电化学发光监测单核苷酸变异的DNA酶驱动动态循环生物传感器
Sirui Yi,Huiping Chen,Haiyan Qiu et al.
Sirui Yi et al.
Nucleic acid-based constitutional dynamic networks (CDNs) can mimic biological events while revealing complex biological processes and their functionalities. In this study, we present a novel dual-signal biosensor that leverages a dissipati...
Sensitive, Low-Cost, Early Detection of Periodontal Disease Using Surface-Enhanced Raman Spectroscopy with Easy-to-Use Silver Nanomesh-Coated Periopaper [0.03%]
基于银纳米网涂布的Perio纸辅助表面增强拉曼光谱技术检测牙周病的研究
Yumeng Jiang,Ryosuke Yanagida,Mitsuko Saito et al.
Yumeng Jiang et al.
Periodontal disease is a widespread inflammatory condition, with growing recognition as a contributor to systemic diseases, including cardiovascular, metabolic, and neurodegenerative disorders. Early diagnosis is critical for effective inte...
Rapid Evaluation of Conversion Coating Degradation Using Automated Scanning Electrochemical Microscopy Approach Curves [0.03%]
基于自动化扫描电化学显微镜的方法曲线快速评价转化膜老化性能退化的研究
Hugo Klinklin,Nicolas Murer,Junsoo Han et al.
Hugo Klinklin et al.
This work aims to quantify electron transfer kinetics from intermediate feedback in automated scanning electrochemical microscopy (SECM) approach curves. Automated tip approach curves are proposed as a high-throughput method to characterize...
Label-Free Evaluation of Osteogenic Differentiation Using Extended-Focus Raman Imaging [0.03%]
基于扩展聚焦拉曼成像的骨诱导性评价
Heqi Xi,Phan Bhongsatiern,Menglu Li et al.
Heqi Xi et al.
Periodontal ligament stem cell (PDLSC)-based therapy has emerged as a promising approach to regenerate damaged periodontal tissue in periodontitis treatments. To advance the application of this therapy, a nondestructive method to monitor os...
An Automated Multi-Sample Digital LAMP Platform for Quantitative Detection of SDC2 Methylation in Colorectal Cancer [0.03%]
一种自动化多样本数字LAMP平台定量检测结直肠癌中SDC2甲基化
Hao He,Yanzhao Wu,Wei Lai et al.
Hao He et al.
DNA methylation of the SDC2 gene has emerged as a critical biomarker for early detection of colorectal cancer (CRC). However, effective clinical application demands analytical platforms that offer enhanced accuracy, speed, and sample high-t...
Metal-Tannic Acid Nanospheres Empowering DNA Nanoarchitectures for Multimodal Detection of Low-Abundance Pesticide-Resistance Genes [0.03%]
金属鞣酸纳米球增强DNA纳米结构用于低丰度抗性基因的多模态检测
Lijuan Liu,Shuyue Luo,Qingfeng Yao et al.
Lijuan Liu et al.
Rapid and on-site identification of pesticide-resistant genes (PRGs), especially low-abundance single-nucleotide mutations (SNMs) concealed within wild-type sequences, is vital for precision agriculture. However, existing bioassays face cha...
Pepsin-Functionalized Covalent Organic Framework Chiral Membrane Assembly via a Vacuum-Assisted Process for Chiral Separation [0.03%]
真空辅助制备的含胃蛋白酶功能化的手性共价有机框架分离膜用于拆分手性分子
Xiuxiu Li,Qixuan Mu,Ruijun Li et al.
Xiuxiu Li et al.
Chiral covalent organic framework (CCOF) membranes provide a promising direction for the large-scale preparation of optically pure drugs. Unfortunately, the limited types of chiral selectors make it difficult to help balance the contradicti...