On-Chip Raman Spectroscopy for Rapid Antimicrobial Susceptibility Testing from Blood Cultures [0.03%]
基于芯片的拉曼光谱法用于血培养中快速抗菌药物敏感性测试
Richard Grohs,Franziska Hornung,Marie-Luise Enghardt et al.
Richard Grohs et al.
Bloodstream infections are associated with considerable morbidity and mortality, necessitating timely and accurate antimicrobial susceptibility testing (AST) to guide appropriate therapy. Current diagnostic methods primarily rely on culture...
Supramolecular ICT Modulation in π-Extended 2D-Azeno Nanosheets for Reversible Fluorescence Sensing of Spermine at the Sub-10 nM Level [0.03%]
超分子ICT调节π扩展的二维氮杂纳米片用于亚10nM精胺可逆型荧光传感检测
Priyanka Rana,Deepak Dabur,Hui-Fen Wu
Priyanka Rana
Biogenic amine surveillance is central to food safety and clinical diagnostics, yet real-time, selective detection of spermine (SPM) remains challenging due to molecular similarity among amines and probe instability in complex matrices. Her...
Integrated Acoustofluidic Manipulation and Oscillation-Stabilized Magnetic Relaxation Biosensing for Salmonella Detection [0.03%]
声学操控与振荡稳定磁弛豫生物传感集成技术用于沙门氏菌检测
Jiaqing Duan,Yingqiao Zhu,Gaofei Lei et al.
Jiaqing Duan et al.
Reliable pathogen detection in complex suspensions requires both effective sample handling and stable signal generation. Here, we report an acoustofluidic-magnetic relaxation biosensing (MRB) platform for Salmonella detection that combines ...
Systematic Revealing of Plant-Derived Nerve Agent Exposure Markers by In-Source Fragmentation-Enabled HRMS Nontargeted Screening [0.03%]
基于源内裂解的高分辨非目标筛选方法系统揭示植物神经毒剂暴露标志物
Yongqi Li,Yichun Chen,Jia Chen et al.
Yongqi Li et al.
Identifying diverse, uncharacterized plant-derived nerve agent adducts is a formidable challenge for environmental exposure confirmation and forensic attribution. We developed a fragmentation pattern-driven nontargeted screening strategy in...
Overcoming Vertical Spatial Resolution Limitations in Coupled Zircon U-Pb-Hf Analysis by Laser Ablation Split Stream Depth Profiling [0.03%]
利用激光剥蚀分光法克服耦合锆石U-Pb-Hf分析的垂直空间分辨率限制
Yao Lu,Liang-Liang Zhang,Li Liu et al.
Yao Lu et al.
Spatial resolution has long limited the coupled in situ determination of zircon U-Pb ages and Hf isotopic compositions, particularly in grains with thin growth rims and complex core-rim zoning. We present a laser ablation split stream (LASS...
Single-Cell-Derived Rabbit mAb-Based Immunoassay for Simultaneous Detection of Florfenicol and Florfenicol Amine [0.03%]
基于兔单克隆抗体的氟喹诺酮和氟喹诺酮胺同时检测免疫测定法
Peipei Li,Yantong Pan,Yuan Li et al.
Peipei Li et al.
Previously, we speculated that rabbits could produce more diverse and higher-affinity antibodies for small molecules due to their specific, unique antibody structure and antibody evolution mechanism. Here, using a single antibody-secreting ...
A Plasmon-Enhanced Self-Validating Optoelectronic Nanopore for Ultrasensitive and Robust Hydrogen Sulfide Real-Time Monitoring in Single Living Cells [0.03%]
一种等离子体增强型自验证纳米光电子孔，用于单个活细胞中实时监测超灵敏且稳健的氢化硫
Zi-Hui Li,Di Zhang,Li-Dong Chen et al.
Zi-Hui Li et al.
Hydrogen sulfide (H2S) is a key gaseous signaling molecule yet quantifying its dynamics in living cells with high spatiotemporal resolution, sensitivity, and reliability remains a challenge. In contrast to conventional single-use sensors th...
Programmable Energy Dissipation in a DNA-pNIPAM Hybrid Hydrogel for Ultrastable Actuation-Enhanced Biosensing of Acetamiprid [0.03%]
一种用于增强型乙酰胺磷检测的超稳定驱动DNA-pNIPAM混合水凝胶中的可编程能量耗散机制研究
Xinyi Feng,Hao Wang,Tingting Zhang et al.
Xinyi Feng et al.
DNA-based hydrogels are attractive for biosensing due to their molecular recognition and programmability, yet their practical use is severely limited by poor mechanical robustness and rapid fatigue under repeated actuation. Here, we overcom...
Long-Lived, Nonenzymatic Signal Generation Chemiluminescence Immunoassay for Pretreatment-Free Detection of Lincomycin in Milk [0.03%]
长效非酶促信号产生化学发光免疫分析法，用于牛奶中林可霉素的免提取检测
Zhenyuan Chen,Mengyao Wang,Weicheng Lin et al.
Zhenyuan Chen et al.
To address the technical limitations of the short chemiluminescence (CL) lifetime and poor stability of chemiluminescence emission in conventional CL systems, a novel CL with prolonged lifetime and high intensity with nonenzymatic signal ge...
Rational Design of a Fluorogenic Probe for Sphingosine Based on Precisely Controlled Intramolecular Spirocyclization of Coumarin-Rhodamine Hybrid Dye [0.03%]
基于肉桂酰罗丹明杂化染料分子内螺环化精确控制的鞘氨醇荧光探针的理性设计
Junjie Wang,Nayan Zhang,Rong Yun et al.
Junjie Wang et al.
We synthesized a series of coumarin-rhodamine (CR) derivatives with near-infrared fluorescence (NIRF) properties, and found their intramolecular spirocyclization equilibrium strongly depends on the hydrophilicity/hydrophobicity of their 5'-...