Rational Design of a Fluorogenic Probe for Sphingosine Based on Precisely Controlled Intramolecular Spirocyclization of Coumarin-Rhodamine Hybrid Dye
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We synthesized a series of coumarin-rhodamine (CR) derivatives with near-infrared fluorescence (NIRF) properties, and found their intramolecular spirocyclization equilibrium strongly depends on the hydrophilicity/hydrophobicity of their 5'-substituent: the hy... ...
