A Novel, Robust, and Isocratic HPLC-UV Method for the Comprehensive Determination of Enantiomeric Impurity (R-Isomer) in Niraparib Drug Substance [0.03%]
新型手性稳定同浓度流动相色谱法测定尼拉帕利中的(R)-异构体杂质含量的方法学研究
Praveen Kumar Kondaveti,Paul Douglas,Akula Raghunadh et al.
Praveen Kumar Kondaveti et al.
Niraparib is a potent, orally bioavailable inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, specifically targeting PARP-1 and PARP-2 to induce selective cytotoxicity in malignancies by disrupting DNA repair mechanisms. Given that t...
Tuning the Chiroptical Properties of Tellurium Nanocrystals With Geometric Control [0.03%]
通过几何控制调谐碲纳米晶体的圆二色性质
Yufen Zong,Jie Zhu,Xingfu Zhou et al.
Yufen Zong et al.
Chiral ligands have been widely employed to synthesize chiral inorganic nanostructures, and it has often been recognized that the chiroptical properties of synthesized chiral nanostructures are primarily derived from the molecular chirality...
Resolution of Tryptophan Ethyl Ester by Forming Diastereomeric Salts With Di-p-Toluoyl-L-Tartaric Acid [0.03%]
通过与对甲苯酰-D-酒石酸形成非对应盐来拆分L-色氨酸乙酯
Yujing Sun,Yangfeng Peng,Tianzhong Tong et al.
Yujing Sun et al.
A resolution of racemic tryptophan ethyl ester (TrpEt) was performed using L-di-p-toluoyl tartaric acid (L-DTTA) as the resolving agent. Response surface methodology (RSM) was employed to systematically investigate the effects of solvent do...
Vicente Domínguez-Arca
Vicente Domínguez-Arca
The homochirality of life-the exclusive use of L-amino acids and the universal right-handedness of α $$ /alpha $$ -helices-stands as one of the most persistent asymmetries in biology. While often attributed to kinetic or energetic bi...
Asymmetric Synthesis of Pyranonaphthene-Fused Spirooxindoles via Takemoto's Urea-Catalyzed Cascade Three-Component Reactions [0.03%]
塔克莫托尿素催化环三组分反应合成螺内酰胺并吡喃萘骈多氢菲类化合物的研究
Luying Song,Hongming Cui,Xuenan He et al.
Luying Song et al.
Enantioselective construction of spiro[4H-pyranonaphthene-3,3'-oxindole] derivatives was realized through an organocatalytic cascade Michael/cyclization using Takemoto's urea. Under the optimized conditions, the reactions of isatins, malono...
Beyond the Solid Solution: Ordered Enantiomerically Unbalanced Packing in Surface-Confined Tetrahelicene Monolayers [0.03%]
超越固溶体：表面限制四手性烯单层中对映体不平衡有序排列
Aleksandra Cebrat,Kevin Martin,Pingo Mutombo et al.
Aleksandra Cebrat et al.
The two-dimensional crystallization and on-surface chemistry of chiral polycyclic aromatic hydrocarbons provide access to surface-confined symmetry breaking and novel covalently bonded nanostructures. Here, we investigate the self-assembly ...
Design, Synthesis, and Enantioselective Cholinesterase Inhibition of Novel Chiral Anthranilic Diamide Derivatives: In Vitro and In Silico Studies [0.03%]
新型手性邻氨基苯甲酸二胺衍生物的设计、合成及对乙酰胆碱酯酶的不对称抑制作用：体内外研究及分子对接研究
Turgay Tunç,Namık Kılınç,Nadir Demirel et al.
Turgay Tunç et al.
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes are responsible for the hydrolysis of acetylcholine and play a vital role in Alzheimer's disease (AD) pathology. The observation of decreased AChE activity and a significa...
Isolation and Identification of Bioactive Fatty Acid Amides From Piper longum Fruits [0.03%]
长果胡椒果实生物活性脂肪酸酰胺的分离与鉴定
Guanghui Gou,Wenli Bao,Liu Liu et al.
Guanghui Gou et al.
Four pairs of previously undescribed fatty acid amide enantiomers [(+)-1/(-)-1 - (+)-4/(-)-4] bearing a trans-epoxide, and 12 known compounds (5-14) were isolated from the fruits of Piper longum L. Their structures were elucidated using spe...
Engineering Chirality in the Solid State: Co-Crystallization as a Strategy for Chiral Induction and Resolution [0.03%]
固态中的手性工程：共结晶作为手性诱导和解析的策略
Ramamohana Reddy Maddike,Vivek Sharma,Rajasekhar V S R Pullabhotla et al.
Ramamohana Reddy Maddike et al.
Chirality plays a fundamental role in chemistry, biology, and materials science, where molecular activity and performance often depend on enantiomeric purity. However, most synthetic methods produce racemic mixtures, making efficient strate...
Urea/Thiourea-Functionalized BPPFA Ligands for Highly Efficient Chiral Extraction of Amino Acids [0.03%]
用于高效拆分氨基酸的手性尿素/硫脲修饰的BPPFA配体
Jiayi Zhou,Shuping Qin,Shaocheng Tan et al.
Jiayi Zhou et al.
The development of efficient chiral extractants is a central objective in the field of chiral extraction. In this study, a series of urea/thiourea functionalized BPPFA ligands (UT-BPPFA) were synthesized and employed as chiral extractants f...