Asymmetric Synthesis of Pyranonaphthene-Fused Spirooxindoles via Takemoto's Urea-Catalyzed Cascade Three-Component Reactions [0.03%]
Luying Song,Hongming Cui,Xuenan He et al.
Luying Song et al.
Enantioselective construction of spiro[4H-pyranonaphthene-3,3'-oxindole] derivatives was realized through an organocatalytic cascade Michael/cyclization using Takemoto's urea. Under the optimized conditions, the reactions of isatins, malono...
Beyond the Solid Solution: Ordered Enantiomerically Unbalanced Packing in Surface-Confined Tetrahelicene Monolayers [0.03%]
Aleksandra Cebrat,Kevin Martin,Pingo Mutombo et al.
Aleksandra Cebrat et al.
The two-dimensional crystallization and on-surface chemistry of chiral polycyclic aromatic hydrocarbons provide access to surface-confined symmetry breaking and novel covalently bonded nanostructures. Here, we investigate the self-assembly ...
Design, Synthesis, and Enantioselective Cholinesterase Inhibition of Novel Chiral Anthranilic Diamide Derivatives: In Vitro and In Silico Studies [0.03%]
新型手性邻氨基苯甲酸二胺衍生物的设计、合成及对乙酰胆碱酯酶的不对称抑制作用：体内外研究及分子对接研究
Turgay Tunç,Namık Kılınç,Nadir Demirel et al.
Turgay Tunç et al.
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes are responsible for the hydrolysis of acetylcholine and play a vital role in Alzheimer's disease (AD) pathology. The observation of decreased AChE activity and a significa...
Isolation and Identification of Bioactive Fatty Acid Amides From Piper longum Fruits [0.03%]
长果胡椒果实生物活性脂肪酸酰胺的分离与鉴定
Guanghui Gou,Wenli Bao,Liu Liu et al.
Guanghui Gou et al.
Four pairs of previously undescribed fatty acid amide enantiomers [(+)-1/(-)-1 - (+)-4/(-)-4] bearing a trans-epoxide, and 12 known compounds (5-14) were isolated from the fruits of Piper longum L. Their structures were elucidated using spe...
Engineering Chirality in the Solid State: Co-Crystallization as a Strategy for Chiral Induction and Resolution [0.03%]
固态中的手性工程：共结晶作为手性诱导和解析的策略
Ramamohana Reddy Maddike,Vivek Sharma,Rajasekhar V S R Pullabhotla et al.
Ramamohana Reddy Maddike et al.
Chirality plays a fundamental role in chemistry, biology, and materials science, where molecular activity and performance often depend on enantiomeric purity. However, most synthetic methods produce racemic mixtures, making efficient strate...
Urea/Thiourea-Functionalized BPPFA Ligands for Highly Efficient Chiral Extraction of Amino Acids [0.03%]
用于高效拆分氨基酸的手性尿素/硫脲修饰的BPPFA配体
Jiayi Zhou,Shuping Qin,Shaocheng Tan et al.
Jiayi Zhou et al.
The development of efficient chiral extractants is a central objective in the field of chiral extraction. In this study, a series of urea/thiourea functionalized BPPFA ligands (UT-BPPFA) were synthesized and employed as chiral extractants f...
Control of Chiroptical Properties on Chiral Phosphangulenes Having Azobenzene Moieties by Photoirradiation Based on Synergistic Exciton Coupling [0.03%]
基于协同 exciton 偶合的光照射对偶氮苯取代的手性磷杂戊轮光学活性的控制
Masaki Yamamura,Kazu Nin,Tatsuya Nabeshima
Masaki Yamamura
C3-symmetric phosphangulene derivatives feature planar chirality with high inversion barrier due to the phosphorus atom. Chiral phosphangulenes have been extensively studied in recent years and have been reported to show exceptionally chara...
Asymmetric Synthesis and Antibacterial Evaluation of β-Substituted (S)-α-Alanine Analogs Containing a Piperazine Moiety in the Side Chain [0.03%]
含侧链哌嗪结构的β-取代(S)-α-氨基酸类似物的不对称合成及抗菌活性研究
Emma A Khachatryan,Anna F Mkrtchyan,Anahit M Hovhannisyan et al.
Emma A Khachatryan et al.
A series of novel enantiomerically enriched α-amino acids containing piperazine fragments were synthesized via nucleophilic addition of piperazine derivatives (2a-d) to the C = C bond of a square-planar Ni (II) complex of the Schiff base d...
Synthesis and Photophysical Properties of Chiral Diaminodicyanoquinodimethane: Formation Mechanism and Chiroptical Properties [0.03%]
手性二氨基二氰基喹二甲烷的合成及光物理性质：形成机制及圆二色谱性质研究
Aslınur Gokpinar,Perihan Ozturk,Duygu Tan et al.
Aslınur Gokpinar et al.
Chirality is fundamental to biological systems and the pharmaceutical industry, yet efficient methods for determining the absolute configuration of chiral compounds remain a challenge. This study reports the synthesis and characterization o...
Cyclodextrin Metal-Organic Framework With Amino Acid Chiral Ligands for Capillary Electrochromatographic Enantioseparation [0.03%]
手性氨基酸配体金属有机框架材料的制备及其毛细管电色谱拆分应用研究
Xiaozhen Shao,Guangfu Xu,Jiaquan Chen et al.
Xiaozhen Shao et al.
Metal-organic frameworks (MOFs) are widely used in the field of chromatographic separation due to their unique properties. A vapor diffusion method was used to synthesize the cyclodextrin MOF (CD-MOF) with D-histidine (D-His) as a chiral li...