Chiral Tetraazacalix-Triazine Derivatives as Organocatalysts for Asymmetric Direct Aldol Reactions: Synthesis and Enantioselective Evaluation [0.03%]
手性的四氮杂杯三苯并庚烷衍生物作为不对称直接aldol反应的有机催化剂：合成与对映选择性评价
Ummu Ozgun,Hayriye Nevin Genc,Abdulkadir Sirit
Ummu Ozgun
Novel tetraazacalix derivatives were synthesized and evaluated for their catalytic performance in direct asymmetric aldol reactions carried out in organic solvents. Chiral functionalities were introduced onto the tetraazacalix[2]arene[2]tri...
Absolute Configuration Assignment From a Single Reflection Using Resonant X-Ray Diffraction [0.03%]
基于共振X射线衍射的单晶反演中心绝对构型确定法
Anmol Andotra,Fabian Gasser,Ferdinando Malagreca et al.
Anmol Andotra et al.
Determination of the absolute configuration of chiral molecules is essential across multiple scientific disciplines, as handedness determines the chiroptical, biological, and pharmaceutical properties. For crystalline materials, single crys...
Brison A Shira,Mahdiyeh Shahi,R Graham Cooks
Brison A Shira
Mass spectrometry (MS) has a role to play in chiral chemistry, in part through methods based on microdroplets and non-covalent molecular clusters. High-throughput MS reaction screening and chiral anal0ysis use microdroplet sprays to perform...
Chiral Resolution of Aspartic Acid Racemate by Single Crystallization With Phenylalanine as Additive [0.03%]
L-苯丙氨酸作为添加剂的D/L-天冬氨酸对映体拆分中的单次结晶实验研究
Xiaohong Xue,Sheng Gong,Jiali Wen et al.
Xiaohong Xue et al.
The effective chiral resolution of amino acid racemates has important significance in fields such as medicine and pharmaceuticals. By using phenylalanine as additive, the chiral resolution of aspartic acid racemate was investigated through ...
Diastereotopic Fluorines of CF2 Group as Stereochemical Probes for Empirical 19F NMR-Based Assignment of Absolute Configuration of an Epimeric Center. 21,21-Difluorothevinols [0.03%]
差向异构氟化物作为立体化学探针用于绝对构型的实验证实：21,21-二氟长春醇类化合物
M V Zelentsova,Zh A Lopantseva,M I Godovikova et al.
M V Zelentsova et al.
The chemical shifts of diastereotopic fluorine atoms in compounds of the formula ArC(R)(OH)CF2R' with unchanged R and R' are weakly dependent on the substituents on the aryl group. In the presence of a chiral group R*, the chemical shifts o...
Enantioselective Resolution of β- and γ-Lactams by a Single Amidase From Rhodococcus baikonurensis Enables Efficient Access to Key Intermediates for Paclitaxel and Carbocyclic Nucleosides [0.03%]
芽孢杆菌来源单一酰胺酶对β-和γ-内酯的不对称拆分促进抗癌药物紫杉醇及 carbocyclic核苷关键中间体的高效获取
Shaozhou Zhu,Hang Wang,Linlin Yang et al.
Shaozhou Zhu et al.
Enantiomerically pure β- and γ-lactams are vital chiral building blocks widely used in the synthesis of antiviral and anticancer drugs. However, producing them on a large scale through chemical synthesis and enantiomeric separation is bot...
A Comparative Study of the Influence of Water and Temperature on the Racemization of Five- and Six-Membered l-Alanine-Derived Imides [0.03%]
水和温度对五元和六元l-丙氨酸衍生物亚胺差向异构化影响的比较研究
Diksha U Sawant,William Chant,Peter Halat et al.
Diksha U Sawant et al.
Racemization of l-alanine-derived imides is enhanced with high-water content and elevated temperature in dimethylformamide (DMF). Water hydrolyses DMF to give dimethylamine (DMA) and formic acid (FA), resulting in an increase in the basicit...
In Silico Analysis of Enantioselective Binding of Pomalidomide Targets for Multiple Myeloma [0.03%]
帕姆洛莫迪德手性选择性靶点的分子对接研究模拟分析
Gyan Vardhan,Vikas Kumar,Ashish Kumar et al.
Gyan Vardhan et al.
Pomalidomide is a 2nd-generation chiral immunomodulatory (IMiDs) drugs and have antiangiogenic activity. Despite being teratogenic, it has been shown to be effective in treating multiple myeloma. Enantioselectivity, chemical structure, and ...
Consequences of Mechanical Bonding on the Optical Activity of Cyclo[18]carbon Rings [0.03%]
机械键合对环状 cyclo[18]carbon 光学活性的影响
Afton Gustafson,Sophia Sburlati,Bart Kahr
Afton Gustafson
The computed nonresonant optical activity of pairs of cyclo[18]carbon rings, linked and unlinked with the same symmetry, D2d, are compared. For optically active, non-enantiomorphous systems, we emphasize that the observables computed here c...
Green Chiral HPLC Method for Lumefantrine Analysis: Method Development, Greenness Assessment, and Computational Studies [0.03%]
卢莫法尼的绿色手性HPLC检测方法：研发、绿色度评估及计算研究
Amanda Mohr,Gustavo Machado das Neves,Érika Segala et al.
Amanda Mohr et al.
Currently, greening analytical methods have become of great interest to ensure operators' and environment health. Chiral analysis can commonly employ hazardous chemicals and large quantities of waste. In this context, this study presents a ...