A Novel, Robust, and Isocratic HPLC-UV Method for the Comprehensive Determination of Enantiomeric Impurity (R-Isomer) in Niraparib Drug Substance
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Niraparib is a potent, orally bioavailable inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, specifically targeting PARP-1 and PARP-2 to induce selective cytotoxicity in malignancies by disrupting DNA repair mechanisms. Given that the S-niraparib exhib... ...
