Diastereotopic Fluorines of CF2 Group as Stereochemical Probes for Empirical 19F NMR-Based Assignment of Absolute Configuration of an Epimeric Center. 21,21-Difluorothevinols
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The chemical shifts of diastereotopic fluorine atoms in compounds of the formula ArC(R)(OH)CF2R' with unchanged R and R' are weakly dependent on the substituents on the aryl group. In the presence of a chiral group R*, the chemical shifts of the fluorine ato... ...
