James Briscoe,Craig E Franklin,Daniel A Gorelick et al.
James Briscoe et al.
An endoplasmic reticulum-associated structure sequesters misassembled FG-Nups to help maintain NPC function [0.03%]
与内质网相关的结构隔离错误组装的FG-Nups以帮助维持核孔复合物的功能
Madison Pletan,Emily Wang,Luke Gohmann et al.
Madison Pletan et al.
Misassembly of nucleoporins (Nups), central components of the nuclear pore complex (NPC), leads to Nup mislocalization outside of the nuclear envelope. Here we elucidate the fate of mislocalized Nups. To impair Nup assembly, we depleted the...
Corey N Cunningham,Jonathan G Van Vranken,Jakeline Larios et al.
Corey N Cunningham et al.
Mitochondria perform diverse functions, such as producing ATP through oxidative phosphorylation, synthesizing macromolecule precursors, maintaining redox balance, and many others. Given this diversity of functions, we and others have hypoth...
Disruption of ER-mitochondria contact sites induces autophagy-dependent loss of P-bodies through the Ca2+-CaMKK2-AMPK pathway [0.03%]
内质网-线粒体接触点的破坏通过Ca2+-CaMKK2-AMPK通路引起P体的自噬依赖性丢失
Nikhil More,Jomon Joseph
Nikhil More
P-bodies (PBs) and stress granules (SGs) are conserved, non-membranous cytoplasmic condensates of RNA-protein complexes. PBs are implicated in post-transcriptional regulation of gene expression through mRNA decay, translational repression a...
Mary Fesenko,Daniel J Moore,Peyton Ewbank et al.
Mary Fesenko et al.
Cells are filled with thousands of vesicles, which mediate protein transport and ensure homeostasis of the endomembrane system. Distinguishing these vesicles functionally and molecularly represents a major challenge. Intracellular nanovesic...
Miro1 expression alters global gene expression, ERK1/2 phosphorylation, oxidation, and cell cycle progression [0.03%]
Miro1的表达改变全局基因表达，ERK1/2磷酸化，氧化和细胞周期进程
Nathaniel Shannon,Cory Raymond,Chloe Palmer et al.
Nathaniel Shannon et al.
Mitochondrial positioning supports localized energy and signaling requirements. Miro1 is necessary for attachment of mitochondria to microtubule motor proteins for trafficking. When Miro1 is deleted (Miro1-/-) from mouse embryonic fibroblas...
Compound screening in human airway basal cells identifies Wnt pathway activators as potential pro-regenerative therapies [0.03%]
人在呼吸道基底细胞中的复合筛选鉴定Wnt通路激活剂作为潜在的促再生治疗方案
Yuki Ishii,Jessica C Orr,Marie-Belle El Mdawar et al.
Yuki Ishii et al.
Regeneration of the airway epithelium restores barrier function and mucociliary clearance following lung injury and infection. The mechanisms regulating the proliferation and differentiation of tissue-resident airway basal stem cells remain...
Feeling the force from within - new tools and insights into nuclear mechanotransduction [0.03%]
从内部感受力量—核力学传导的新工具和新认识
Julien Morival,Anna Hazelwood,Jan Lammerding
Julien Morival
The ability of cells to sense and respond to mechanical signals is essential for many biological processes that form the basis of cell identity, tissue development and maintenance. This process, known as mechanotransduction, involves crucia...
Piezo1-induced durotaxis of pancreatic stellate cells depends on TRPC1 and TRPV4 channels [0.03%]
胰腺星状细胞中由Piezo1引发的刚性依赖迁移需要TRPC1和TRPV4通道参与
Ilka Budde,André Schlichting,David Ing et al.
Ilka Budde et al.
Pancreatic stellate cells (PSCs) are primarily responsible for producing the stiff tumor tissue in pancreatic ductal adenocarcinoma (PDAC). Thereby, PSCs generate a stiffness gradient between the healthy pancreas and the tumor. This gradien...
André Ventura-Gomes,Maria Carmo-Fonseca
André Ventura-Gomes
Properly timed gene expression is essential for all aspects of organismal physiology. Despite significant progress, our understanding of the complex mechanisms governing the dynamics of gene regulation in response to internal and external s...