Piezo1-induced durotaxis of pancreatic stellate cells depends on TRPC1 and TRPV4 channels
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Pancreatic stellate cells (PSCs) are primarily responsible for producing the stiff tumor tissue in pancreatic ductal adenocarcinoma (PDAC). Thereby, PSCs generate a stiffness gradient between the healthy pancreas and the tumor. This gradient induces durotaxis,... ...
