Chronic stress disrupts the network among stress granules, processing bodies and motor proteins [0.03%]
慢性压力会破坏应激颗粒、处理体和运动蛋白之间的网络关系
Yuichiro Adachi,Masashi Masuda,Yutaka Taketani et al.
Yuichiro Adachi et al.
Stress granules (SGs) are dynamic RNA condensates that assemble rapidly in response to cellular stress following translational arrest, thereby promoting adaptation and influencing disease pathogenesis. Although SG assembly and disassembly d...
Migration and establishment of progenitor pool of melanocytes is governed by SEMA3E-PLXND1 signaling [0.03%]
SEMAsignaling调控黑色素干细胞迁入并定居毛囊示意图
Yogaspoorthi Subramaniam,Babita Sharma,Keerthic Aswin et al.
Yogaspoorthi Subramaniam et al.
Transitory signaling events often hinder the identification of pathways governing cell migration and stem cell establishment during development. Using zebrafish and cultured mammalian melanocytes, we identify a previously unrecognized role ...
DHHC21 is a STIM1 protein S-acyltransferase that modulates immune function in vivo [0.03%]
DHHC21是体内STIM1蛋白S-酰基转移酶，可调节免疫功能
Goutham Kodakandla,Ying Fan,Michael X Zhu et al.
Goutham Kodakandla et al.
Depletion of Ca2+ from ER stores leads to the activation of Ca2+ channels on the plasma membrane known as store-operated Ca2+ entry. The proteins STIM1 and STIM2 function as ER Ca2+ sensors, and upon store depletion, they undergo a conforma...
Increased tissue tension caused by depletion of CLDN3 in the non-neural ectoderm causes neural tube defects in chick embryos [0.03%]
卵黄囊鸡胚胎中非神经外胚层CLDN3耗竭导致组织张力增高和神经管缺陷
Elizabeth-Ann Legere,Marie Dumont,Jordan A Dias et al.
Elizabeth-Ann Legere et al.
Neural tube morphogenesis provides a dynamic setting in which to study epithelial cell behaviours. Here, we examined CLDN3-dependent biomechanical properties of the non-neural ectoderm during neural tube closure in chick embryos. Previous a...
Reconstitution of lamin assembly on nuclear pore complex-containing membranes [0.03%]
含有核孔复合体的膜上重建核纤层装配
Ross T A Pedersen,Yinyin Zhuang,Andres V Reyes et al.
Ross T A Pedersen et al.
Intermediate filaments called lamins line the metazoan nuclear envelope and organize the nucleus and genome. Unlike actin and microtubules, purified intermediate filament proteins assemble into non-physiological structures, making it diffic...
Reconstitution of lamin assembly on nuclear pore complex-containing membranes [0.03%]
含有核孔复合体的膜上重建核纤层装配
Ross T A Pedersen,Yinyin Zhuang,Andres V Reyes et al.
Ross T A Pedersen et al.
Intermediate filaments called lamins line the metazoan nuclear envelope and organize the nucleus and genome. Unlike actin and microtubules, purified intermediate filament proteins assemble into non-physiological structures, making it diffic...
Maxim Averbukh,Tiffany Wang,Gilberto Garcia et al.
Maxim Averbukh et al.
The actin cytoskeleton is a highly dynamic and evolutionarily conserved multi-protein complex that regulates cellular architecture, mechanics and intracellular organization. Although actin dynamics and organization have been extensively stu...
Oncogenic PIK3CA enhances collective migration of mammary epithelial cells through ERK wave propagation [0.03%]
致癌基因PIK3CA通过ERK波传播增强乳腺上皮细胞的集体迁移
Ali Dayoub,Artem I Fokin,Sergey Leonov et al.
Ali Dayoub et al.
Oncogenic mutations of the PIK3CA gene, which encodes the catalytic subunit of the phosphatidylinositol 3-kinase (PI3K) enhance cell migration via ERK (ERK1 and ERK2, also known as MAPK3 and MAPK1, respectively) activation. We analyzed the ...
Oncogenic PIK3CA enhances collective migration of mammary epithelial cells through ERK wave propagation [0.03%]
致癌性PIK3CA通过ERK波传播增强乳腺上皮细胞的集体迁移
Ali Dayoub,Artem I Fokin,Sergey Leonov et al.
Ali Dayoub et al.
Oncogenic mutations of the PIK3CA gene, which encodes the catalytic subunit of the phosphatidylinositol 3-kinase (PI3K) enhance cell migration via ERK (ERK1 and ERK2, also known as MAPK3 and MAPK1, respectively) activation. We analyzed the ...
TRIM28 regulate G2/M transition via histone modification and DNA damage repair during mouse oocyte meiosis [0.03%]
TRIM28通过组蛋白修饰和减数分裂卵母细胞中的DNA损伤修复调节G2 / M转换
Rui-Jie Ma,Meng-Meng Tang,Ping-Shuang Lu et al.
Rui-Jie Ma et al.
TRIM28, a member of the tripartite motif (TRIM) family, functions as a transcriptional coregulator involved in maintaining genome stability during mitosis. However, transcriptional activity is barely detectable during oocyte meiotic maturat...