A C-terminal cytoplasmic retention motif and nuclear localization signal regulates nuclear import of TP53INP2/DOR [0.03%]
C端细胞质滞留基序和核定位信号调控TP53INP2/DOR的核输入
Birendra Kumar Shrestha,Eva Sjøttem,Hallvard Lauritz Olsvik et al.
Birendra Kumar Shrestha et al.
Tumor protein p53 inducible nuclear protein 2 (TP53INP2) is a multifunctional protein involved in transcriptional coactivation, ribosomal RNA synthesis, and autophagy, regulated by subcellular localization. Using CRISPR/Cas9-generated TP53I...
Trypanosome bloodstream-specific flagellum attachment proteins can mediate attachment in an insect surface coat environment [0.03%]
血红素特异型锥体虫附着蛋白可在昆虫表皮环境下介导细胞连接
Laryssa Vanessa de Liz,Hannah Pyle,Patrícia Hermes Stoco et al.
Laryssa Vanessa de Liz et al.
Throughout the life cycle of the unicellular parasite Trypanosoma brucei, its single flagellum remains laterally attached to the cell body by FLA and FLABP proteins, even as the parasite differentiates from the bloodstream form (BSF), found...
Paclitaxel compromises nuclear integrity in interphase through SUN2-mediated cytoskeletal coupling [0.03%]
紫杉醇通过SUN2介导的细胞骨架连接破坏间期核完整性
Thomas Hale,Victoria L Hale,Piotr Kolata et al.
Thomas Hale et al.
Regulation of Lamin A/C levels and distribution is crucial for nuclear integrity and mechanotransduction via the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex. Dysregulation of Lamin A/C correlates with poor cancer prognosis, and...
FLIM intensity-based image segmentation reveals upregulated energy metabolism and chemotherapy sensitivity in MCF-7 cells [0.03%]
基于FLIM强度的图像分割揭示了MCF-7细胞中能量代谢上调和化疗敏感性
Yu-Kai Huang,Mary Zhuang,Michelle A Digman
Yu-Kai Huang
Mitochondrial transfer to recipient cells triggers a respiratory burst by increasing ATP production and cellular energy metabolism. However, its impact on intracellular metabolic shifts remains unclear. This study introduces a novel methodo...
Selective disruption of microtubule formation at the nuclear envelope impairs the bone resorption capacity of osteoclasts [0.03%]
细胞核包膜处微管形成的靶向性干扰会损害破骨细胞的溶骨能力
Silvia Vergerajauregui,Samantha Panea,Jakob O Oltmanns et al.
Silvia Vergerajauregui et al.
Microtubule organization plays a central role in cell differentiation, orchestrating essential processes such as cell polarization, mechanotransduction, organelle positioning, and intracellular transport. A hallmark of many differentiated c...
Bile canaliculi formation in primary hepatocytes requires α1β1 integrin-dependent adherens junction re-organization [0.03%]
胆小管的形成需要α1β1整合素依赖性的粘合带重构
David Cohen,Francisco Lázaro-Diéguez,Anne Müsch
David Cohen
Hepatocytes, the parenchymal cells of the liver, exhibit a unique epithelial polarity phenotype in which their bile canaliculi-forming luminal domains and underlying F-actin-linked cell-cell adhesion belt organize not parallel but perpendic...
Emma Burns,Anastasia Amoiroglou,Carey J Fagerstrom et al.
Emma Burns et al.
A significant challenge in Drosophila centriole biology is its small size. Advanced super-resolution techniques have provided valuable insights, but require specialized equipment and can be difficult to implement in tissues. Expansion Micro...
Molecular mechanisms of the lysosomal damage response and its roles in aging and disease [0.03%]
溶酶体损伤反应的分子机制及其在衰老和疾病中的作用
Shuhei Nakamura,Takayuki Shima,Tamotsu Yoshimori
Shuhei Nakamura
Lysosomes are the main digestive organelles and serve as a signaling hub linking environmental cues to cellular metabolism. Through these functions, lysosomes play a crucial role in maintaining cellular and organismal homeostasis. However, ...
RNA-binding protein RNP1A is highly essential and interacts with Contractility Kit proteins to facilitate cell mechanics [0.03%]
RNA结合蛋白RNP1A高度必要且与Contractility Kit蛋白相互作用以促进细胞力学性能
Yinan Liu,Mark Allan Co Jacob,Jessica Leng et al.
Yinan Liu et al.
Cell shape regulation is important for many biological processes. Some cell shape-regulating proteins harbor mechanoresponsive properties that enable them to sense and respond to mechanical cues. In Dictyostelium discoideum, mechanoresponsi...
Leanna Owen,Margot Riggi,David G Drubin et al.
Leanna Owen et al.
Clathrin-mediated endocytosis (CME) is an essential, highly conserved process in eukaryotic cells that facilitates the internalization of plasma membrane components, transmembrane proteins and extracellular nutrients. This complex pathway i...