Abnormal nucleoli architecture and aggregate formation in Nucleophosmin mutated Acute Myeloid Leukaemia [0.03%]
Nucleophosmin突变的急性髓系白血病中的异常核仁结构和聚集形成
Martin Grundy,Kellie Lucken,Xiaomeng Xing et al.
Martin Grundy et al.
Mutations in the Nucleophosmin (NPM1) gene represent the most common genetic alteration in Acute Myeloid Leukaemia (AML) and result in mis-localisation of the mutated protein from a predominantly nucleolar localisation to a predominantly cy...
Med12 cooperates with multiple differentiation signals to facilitate efficient lineage transitions in embryonic stem cells [0.03%]
Med12通过与多种分化信号相互作用促进胚胎干细胞中高效的系别转换
Max Fernkorn,Christian Schröter
Max Fernkorn
Cell differentiation results from coordinated changes in gene transcription in response to combinations of signals. FGF, Wnt, and mTOR signals regulate the differentiation of pluripotent mammalian cells towards embryonic and extraembryonic ...
Approaches to reduce succinate accumulation by restoration of succinate dehydrogenase activity in cultured adrenal cells [0.03%]
通过恢复培养的肾上腺细胞中的琥珀酸脱氢酶活性来减少琥珀酸积累的方法
Fatimah Al Khazal,Leili Rahimi,Fan Feng et al.
Fatimah Al Khazal et al.
The rare human neuroendocrine tumors pheochromocytoma and paraganglioma (PPGL) can result from loss of mitochondrial succinate dehydrogenase. The resulting succinate accumulation is tumorigenic in certain neuroendocrine cells. Here we explo...
The P4-phospholipid flippase Atp11a is required for maintenance of eye and ear structure in zebrafish [0.03%]
斑马鱼眼睛和耳朵结构维持需要P4-磷脂翻转酶Atp11a
Alexia Hawkey-Noble,Cameron Tobin,Muhammad Ameen et al.
Alexia Hawkey-Noble et al.
The atp11a gene encodes a phospholipid flippase protein required to flip phosphatidylserine (PS) and phosphatidylethanolamine (PE) from the outer leaflet of the cytoplasmic membrane to the inner leaflet. Mutations in ATP11A have been descri...
Gustavo G Pacheco,Bette J Dzamba,Wakako Endo et al.
Gustavo G Pacheco et al.
The mechanistic links between mechanical forces and bioenergetics remain elusive. We report an increase in mitochondrial membrane potential (MMP) along the leading row of collectively migrating Xenopus laevis mesendoderm cells at sites wher...
NHR-85 modulates mitochondrial and lipid homeostasis to protect against α-synuclein aggregation in C. elegans [0.03%]
NHR-85通过调节线粒体和脂质稳态来保护秀丽隐杆线虫免受α-突触核蛋白聚集的损害
Dikaia Tsagkari,Maria Markaki,Nektarios Tavernarakis
Dikaia Tsagkari
Peroxisome proliferator-activated receptors (PPARs), such as PPARδ, are transcription factors that play a pivotal role in energy and fat metabolism. PPARδ activates genes involved in lipid and glucose metabolism and is expressed in variou...
Integrated proteome and lipidome analyses place OCIAD1 at mitochondria-peroxisome intersection balancing lipid metabolism [0.03%]
整合型蛋白质组和脂质组分析将OCIAD1置于线粒体-过氧化物酶体交界处以平衡脂质代谢
Vanessa Linke,Mateusz Chodkowski,Kacper Kaszuba et al.
Vanessa Linke et al.
OCIAD1 (Ovarian Cancer Immunoreactive Antigen Domain Containing 1) is a membrane protein largely localized to mitochondria, however, its function in health or disease is not well understood. To comprehensively characterize the molecular cha...
Kunlun Yin,Luke Villareal,Xiangxiang Wu et al.
Kunlun Yin et al.
Colorectal cancer (CRC) remains a major global health concern, necessitating advancements in therapeutic strategies. Understanding the mechanisms driving CRC is crucial for developing effective treatments. Previous studies, including our ow...
Practical considerations for data exploration in quantitative cell biology [0.03%]
定量细胞生物学中数据探索的实用考量因素
Joanna W Pylvänäinen,Hanna Grobe,Guillaume Jacquemet
Joanna W Pylvänäinen
Data exploration is an essential step in quantitative cell biology, bridging raw data and scientific insights. Unlike polished, published figures, effective data exploration requires a flexible, hands-on approach that reveals trends, identi...
Tumor acidosis supports cancer cell lipid uptake via a rapid, transporter-independent mechanism [0.03%]
肿瘤酸中毒通过快速、非转运蛋白依赖的机制支持癌细胞脂质摄取
Marc Severin,Rikke K Hansen,Michala G Rolver et al.
Marc Severin et al.
Tumor acidosis alters cancer cell metabolism and favors aggressive disease progression. Cancer cells in acidic environments increase lipid droplet (LD) accumulation and oxidative phosphorylation, characteristics of aggressive cancers. Here,...