Approaches to reduce succinate accumulation by restoration of succinate dehydrogenase activity in cultured adrenal cells
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The rare human neuroendocrine tumors pheochromocytoma and paraganglioma (PPGL) can result from loss of mitochondrial succinate dehydrogenase. The resulting succinate accumulation is tumorigenic in certain neuroendocrine cells. Here we explore two theoretical a... ...
