Sulfonated and sulfated lignans/neolignans from an aqueous extract of Isatis indigotica roots [0.03%]
菘蓝根水提物中木脂素和 neo-木脂素的硫酸化及磺酸基化修饰产物
Jia-Yi Feng,Yu-Feng Liu,Xiao-Qiang Lei et al.
Jia-Yi Feng et al.
Five sulfonated and sulfated lignans/neolignans (1-5), together with a neolignan analogue (6), were isolated from an aqueous extract of the Isatis indigotica roots (ban lan gen). Their structures were determined by spectral data analysis in...
Three new limonoids with high oxidation from the fruits of Aglaia edulis [0.03%]
三种果色源柚木中的新型橙皮素类高氧化产物
Han-Sheng Lv,Hou-Li Jiang,Yu-Jin Sun et al.
Han-Sheng Lv et al.
Agledulines L-N (1 - 3), three previously undescribed limonoids with the A/D-ring-seco structural characteristics and high degree oxidation, along with the three reported compounds (4 - 6), were isolated from the fruits of Aglaia edulis. Th...
Design and synthesis of a novel β-anhydroicartin derivative targeting tumor cell mitochondria based on the regulation of p16INK4a and its in vitro biological activity evaluation [0.03%]
基于p16INK4a调控的新型β-无水色兰烷衍生物的设计合成及其体外生物学活性评价
Hui Shu,Fang-Fei Liu,Feng-Yan Su et al.
Hui Shu et al.
Based on the regulation of β-anhydroicaritin on the stability of p16INK4a encoded by CDKN2A gene, nine novel triphenylphosphine derivatives targeting tumor cell mitochondria were synthesized. Compound 13 increased the ability to inhibit lu...
Chemical constituents from artemisia annua with potential anti-inflammatory activities [0.03%]
具有潜在抗炎活性的 Artemisia annua 成分
Qi-Guo Wu,Si-Meng Li,Ye-Qing Hu et al.
Qi-Guo Wu et al.
Phytochemical analysis of Artemisia annua aerial parts revealed three novel lignan glycosides (arteannuoside A-B, annusesquilignanoside) and 18 known compounds (4-21), including spanning megastigmanes (4-13), coumarin (14), nitrogen-contain...
Integrated meta-analysis, network pharmacology, computational biology, and in vitro experimental verification to reveal the anti-fatigue mechanism of Lycium barbarum [0.03%]
基于整合meta分析、网络药理学、计算生物学及体外实验验证的枸杞抗疲劳机制研究
Teng-Teng Huang,Xiao-Ling Chen,Dai-Wen Chen et al.
Teng-Teng Huang et al.
This study aims to elucidate Lycium barbarum (LB)'s anti-fatigue mechanisms. Meta-analysis confirmed LB's anti-fatigue capacity, while network pharmacology, molecular docking, and molecular dynamics simulations identified key targets (SRC, ...
Saikosaponin D, a triterpene saponin from Bupleurum falcatum, restores circadian rhythm and attenuates hepatic fibrosis via Esr1-Per2 axis [0.03%]
防风草三萜皂苷Saikosaponin D通过Esr1-Per2轴恢复昼夜节律并减轻肝纤维化
Yu-Gang Fu,Jun-Min Wang,Si-Min Gu et al.
Yu-Gang Fu et al.
Hepatic fibrosis, a precursor to chronic liver diseases, is linked to circadian rhythm disruptions. This study investigates the anti-fibrotic effects of saikosaponin D (SSd) from Bupleurum falcatum L. and its regulation of circadian genes. ...
Three undescribed diterpenoids from Pini Lignum Nodi with hepatoprotective activities [0.03%]
三种具有保肝活性的青树脂新二萜类化合物
Jia-Qi Chen,Ling-Zhi Zhang,Jie Ma et al.
Jia-Qi Chen et al.
Three new abietane-type diterpenes, named pinusins A-C (1-3) were isolated from Pini Lignum Nodi (the dried tuberculate or branched nodes of Pinus massoniana Lamb.), together with five known diterpenoids (4-8), a flavonoid (9) and a monoter...
Yong-Qiang Wen,Ya-Zhou Wang,Chen-Xu Zhao et al.
Yong-Qiang Wen et al.
Baicalin, a flavonoid derived from the dicotyledonous plant Scutellaria baicalensis Georgi (SBG), is applied to treat various -disorders due to its various pharmacological effects such as anti-inflammatory, antiviral, antibacterial, liver-p...
Chemical constituents from Calophyllum polyanthum and their biological activity [0.03%]
化南马兜铃花的化学成分及生物活性研究
Yin-Xia Yang,Li-Hua Gong,Fu-Hua Peng et al.
Yin-Xia Yang et al.
Phytochemical investigation of Calophyllum polyanthum led to the isolation of six xanthones, six chromanone derivatives, one coumarin, one glycoside and one flavonoid, including two new xanthones named caledonixanthone M (1), caledonixantho...
Characterization of homoisoflavonoids in fresh and dried Portulaca oleracea L. by HPLC-DAD-ESIMS2 [0.03%]
新鲜和干燥的 PORTULACA OLERACEA L. 中同源异黄酮类化合物的分离鉴定（HPLC-DAD-ESI-MS₂）
Hong-Qing Wang,Jun-Hua Sun,Jian-Bo Liu et al.
Hong-Qing Wang et al.
In the study, three types of homoisoflavonoids were isolated from the roots of fresh Portulaca oleracea L. The electrospray ionization (ESI) mass spectral fragmentation pathways of these compounds were proposed. The fragmentation rules were...