Design and synthesis of a novel β-anhydroicartin derivative targeting tumor cell mitochondria based on the regulation of p16INK4a and its in vitro biological activity evaluation
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Based on the regulation of β-anhydroicaritin on the stability of p16INK4a encoded by CDKN2A gene, nine novel triphenylphosphine derivatives targeting tumor cell mitochondria were synthesized. Compound 13 increased the ability to inhibit lung cancer A549 cells... ...
