Mei Tang,Shuo Ju,Yi-Qiong Liu et al.
Mei Tang et al.
Three previously unreported diterpenoid alkaloids were isolated from the ethanol extract of Delphinium trichophorum Franch and named trichophinines A-C (1-3), along with twenty-four known compounds. Compounds 1 and 2 were lycoctonine-type C...
Huan-Yan Liu,Xi-Kang Zheng,Xiao-Rao Chen et al.
Huan-Yan Liu et al.
A new nonribosomal peptide-polyketide (NRP-PK) hybrid, curvularisin (1), and a new polyketide, spiciferone D (2), together with twelve known compounds (3 - 14), were isolated from the mangrove-derived endophytic fungus Curvularia sp. P3. Th...
Empirical rules for efficiently determining the structures and configurations of natural compounds via 1D NMR [0.03%]
Kuo Xu,Ya-Nan Yang,Pei-Cheng Zhang
Kuo Xu
Determining the chemical structures and stereochemistry of natural compounds present in trace amounts via derivatization or hydrolysis is a considerable challenge. Nonetheless, when employing conventional deuterated reagents, consistent pat...
Xanthonolignoids from Hypericum curvisepalum with quorum sensing inhibitory activity against Chromobacterium violaceum [0.03%]
Qiu-Ying He,Sheng-Qiang Yang,Yik-Ling Chew et al.
Qiu-Ying He et al.
Three undescribed xanthonolignoids (1-3), together with eight known analogs (4-11), were isolated from Hypericum curvisepalum. Their structures were elucidated by mass and NMR spectroscopic analyses. In bioassays against Chromobacterium vio...
Genome mining guided discovery of new pentangular polyketides from the marine rare actinomycete Actinoalloteichus hymeniacidonis DSM 45092 [0.03%]
基因组数据挖掘引导的新型五角园环素类化合物的发现：来自海兔放线菌DSM 45092的产物研究
Zi-Yi Yang,Li-Li Sun,Zhuang-Jie Fang et al.
Zi-Yi Yang et al.
Genome mining has become a powerful method for linking biosynthetic gene clusters to chemical structures of their encoded natural products, driven by advances in genomic sequencing and the accumulated knowledge of natural product biosynthes...
Eu(FOD)3 as a shift regent ameliorates the 1H NMR assignments of matrine-type quinolizidine alkaloids [0.03%]
Eu(FOD)3作为移位试剂改进了苦马豆素类型喹喏里西啶生物碱的1H NMR指认
Xiu-Chuan Fu,Qiao Zhang,Ping Yang et al.
Xiu-Chuan Fu et al.
Matrine-type quinolizidine alkaloids (QAs) exhibit complex 1H NMR spectra due to overlapping signals from their CH2 and CH groups, which were crucial for elucidating their structures. Eu(FOD)3 was employed to resolve these overlaps and achi...
Design, synthesis and biological evaluation of asiatic acid derivatives as survivin inhibitors [0.03%]
survivin抑制剂的羟基姜黄素衍生物的设计、合成及生物活性评价
Liang-Feng Zhang,Yong-Hu Qiu,Dong-Ping Xu et al.
Liang-Feng Zhang et al.
Targeting Survivin with small molecules is a validated oncological strategy. Fourteen novel asiatic acid (AA) derivatives incorporating phosphate ester pharmacophores were designed and synthesized guided by the principles of fragment-based ...
Two new polyketides isolated from the endophytic fungus Phomopsis heveicola POH-zhi and its antifungal activity [0.03%]
来自棒曲霉菌POH-zhi的两个新的聚酮类化合物及其抗真菌活性研究
Rui-Han Zhang,Yan Dong,Yi Sun et al.
Rui-Han Zhang et al.
Two new polyketides, demethyl-epiremisporine B (1) and demethyl-coniochaetone A (2), together with four known polyketide compounds including diaportheone A (3), vertixanthone (4), peniphenone (5) and 3,8-dihydroxy-1-propylanthraquinone (6),...
Optimization and development of lycopene-loaded hydrogel for breast cancer using Box-Behnken design [0.03%]
Box-Behnken设计优化并开发用于乳腺癌治疗的番茄红素载药水凝胶
Suman Khurana,Parveen Kumar Goyal,Shrestha Sharma
Suman Khurana
The aim of this study was to optimize, formulate, and evaluate a hydrogel composed of chitosan and β-glycerophosphate (β-GP) for the delivery of lycopene in the treatment of breast cancer. Box-Behnken design (BBD) was employed to optimize...
Precision modulation of the gut microbiota-immune axis by natural products: a structure-activity relationship perspective in cancer immunotherapy [0.03%]
天然产物精准调节肠菌免疫轴的结构活性关系研究进展：癌症免疫治疗视角
Yu-Chen Liu,Bing Liu,Ting Zhu et al.
Yu-Chen Liu et al.
Natural products (NPs) provide a chemically precise strategy to overcome gut dysbiosis-driven resistance in cancer immunotherapy. This review deconstructs how distinct structural determinants of polysaccharides, terpenoids, polyphenols, and...