The guardian that guides: cinnamic acid enhances oral bioavailability of diverse TCM components by reinforcing rather than disrupting intestinal barrier integrity [0.03%]
穿甲而不伤甲：香豆酸通过增强而非破坏肠道屏障完整性来提高多种中药成分的口服生物利用度
Fang-Fang Fan,Meng-Yao Cui,Rui-Han Guo et al.
Fang-Fang Fan et al.
This study established a Caco-2/HT29 co-culture intestinal epithelial model to systematically investigate the intestinal absorption and transport mechanisms of cinnamic acid (CA). The results indicate that CA enhances intestinal barrier int...
Two undescribed bisabolane-type sesquiterpenoids from the endophytic fungus Penicillium herquei [0.03%]
源自内生真菌Penicillium herquei的新倍半萜化合物
Yi-Yang Xiong,Lin-Lin Li,Jing Huang et al.
Yi-Yang Xiong et al.
Sixteen compounds, including two undescribed bisabolane-type sesquiterpenoids (1, 2), four aromatic derivatives (3-6), two cyclopeptides (7, 8), two acyclic sesquiterpenes (9-10), four fatty acid esters (11-14) and two fatty acids (15-16), ...
Three new steroidal alkaloids from the whole plants of Sarcococca ruscifolia [0.03%]
全缘买麻藤中三萜类生物碱的研究
Yong-Jin Ye,Xiao-Hui Sun,Gang Ke et al.
Yong-Jin Ye et al.
ABETRACTThree previously undescribed steroidal alkaloids, 20α-N,N-dimethylamino-2β-hydroxy-3α-senecioylamino-5α-pregnane (1), 20α-N,N-dimethylamino-2β,4α-dihydroxy-3α-senecioylamino-5α-pregnane (2) and 20α-N,N-dimethylamino-2β,15...
Breviscapine alleviates liver fibrosis by inhibiting epithelial-mesenchymal transition via TGF-beta1/Smad3 pathway [0.03%]
益母草素通过TGF-β1/Smad3信号抑制上皮间质转化从而缓解肝纤维化
Xiu-Hong Zhong,Yao Li,Yu-Kun Song et al.
Xiu-Hong Zhong et al.
Liver fibrosis may develop into cirrhosis and liver cancer, lacking effective approved treatments. Breviscapine extracted from Erigeron breviscapus possesses low toxicity and favorable pharmacokinetics, yet its anti-fibrotic mechanisms rema...
Rui Ke,Hai-Qiang Wang,Cheng-Yong Tan et al.
Rui Ke et al.
Four undescribed compounds, including one new sesquiterpene lactone (1, coriarilactone A), two new phenylpropanoid glycosides (2 and 3, corianosides A and B), and one new coumarin (4, coriacoumarin A), together with five known sesquiterpene...
Concise total synthesis of coerulescine by Cu(I)-catalyzed tandem reaction [0.03%]
铜催化串联反应 concise 总结合成 Coerulescine
Bo-Qin Zi,Qiu-Ting Yang,Tian-Feng Peng et al.
Bo-Qin Zi et al.
Herein, we disclosed a concise total synthesis of indole alkaloid coerulescine via a novel copper(I)-catalyzed tandem reaction of chiral tert-butanesulfinyl amide o-iodoanilide derivative with methyl chloroformate as the electrophile reagen...
Synthesis and biological evaluation of aconitine-type derivatives as potential cardiotonic agents [0.03%]
穿心莲型生物碱衍生物的合成及其正性肌力作用评价
Wen-Rong Qu,Xue Wen,Ling-Feng Tian et al.
Wen-Rong Qu et al.
Eighteen C19 aconitine-type derivatives were designed and syn-thesized with the modification of core active and strong toxicity components, such as yunaconitine (YA), mesaconitine (MA), and hypaconitine (HA) in Fuzi through hydrolysis and d...
Shuai-Cong Ni,Hai-Xiao-Lin-Mo Ma,A-Ji Diri et al.
Shuai-Cong Ni et al.
To explore the chemical constituents of Selaginella tamariscina and their effects on cancer cells, this study employed multiple chromatographic techniques including polyamide, silica gel, and semi-preparative High-performance liquid chromat...
Lian Lian,Xin-Xin Zhang,Jun-Yi Ma et al.
Lian Lian et al.
Two previously undescribed cassane diterpenoids, caesmimo C3 (1) and caesmimo C8 (2), were isolated from the seeds of Hultholia mimosoides. Their structures were established by comprehensive spectroscopic analysis, and the absolute configur...
Protective effects of Angelica dahurica polysaccharide on alleviating hippocampus injury induced by ovariectomized/D-galactose in rats by inhibiting oxidative stress and its serum metabolomics [0.03%]
Angelica dahurica多糖通过抑制氧化应激对卵巢切除/ D-半乳糖致大鼠海马损伤的保护作用及其血清代谢组学研究
Fen Qiu,Xue-Qin He,Yi-Zhang Li et al.
Fen Qiu et al.
We established in vivo models of hippocampal oxidative injury to investigate the protective effect of Angelica dahurica polysaccharide (ADP) on the hippocampus. ADP alleviated ovariectomized/D-Galactose (OVX/D-Gal)-induced hippocampal damag...