Withaferin A ameliorates psoriasis-like skin lesions by suppressing oxidative stress in keratinocytes [0.03%]
Withaferin A通过抑制角质形成细胞氧化应激改善银屑病样皮损
Ming-Yi Zhang,Yu-Chang Liu,Xing-Yu Liu et al.
Ming-Yi Zhang et al.
Psoriasis is a chronic disease with elusive pathogenesis linked to genetic, and immune factors. Studies have shown most patients have experienced high levels of oxidative stress, which can lead to inflammation or damage. Withaferin A is a n...
Cytotoxic ent-abietane diterpenoids from the leaves of Croton crassifolius [0.03%]
具细胞毒性的_ent-abies烷型倍半萜醌类化合物及其制备方法和应用
Hao Yu,Hong-Ying Chen,Xue-Jun Wang et al.
Hao Yu et al.
Two new ent-abietane diterpenoids, 2β,15-dihydroxy-ent-abieta-7,13-dien-3-one (1) and 6β,13α-dihydroxy-ent-abieta-8(14)-en-3-one (2), together a known ent-abietane diterpenoid 3α,7β-dihydroxy-ent-abieta-8,11,13-triene (3), were isolate...
Ecdysteroid-enriched fraction of Cyathula officinalis suppresses synovial proliferation and inflammation to ameliorate RA by inhibiting the AKT/PI3K/mTOR signaling pathway [0.03%]
商陆中保幼激素富集组分通过抑制AKT/PI3K/mTOR信号通路改善类风湿性关节炎表型及炎症反应作用机制研究
Yue-Hui Huang,Lu Qiu,Yi Peng et al.
Yue-Hui Huang et al.
This study investigated the chemical compositions isolated from Cyathula officinalis (CES) and elucidated its anti-RA effects and potential mechanisms. In vitro results revealed that CES suppressed interleukin (IL)-1β-stimulated proliferat...
Design, synthesis, and mechanism study of novel natural-based isoquinolone derivatives as potential antifungal agents [0.03%]
新型天然异喹啉衍生物的設計、合成及抗真菌劑機制研究
Wei Chen,Tao Huang,Yan-Xi Jin et al.
Wei Chen et al.
A series of isoquinolone compounds Ia-Iq containing amide moiety were rationally designed and synthesized based-on isoquinolone alkaloids. Their structures were confirmed by 1H NMR,13C NMR and HRMS. Most of the title compounds showed medium...
Xin-Yang Liu,Jing-Jing Zhang,Qian-Qian Yin et al.
Xin-Yang Liu et al.
Eleven compounds were isolated from the n-butanol extract of Aglaia odorata Lour, including one undescribed lignan, curlignan-4-O-β-D-glucopyranoside (1), and ten known compounds (2-11). Their structures were characterized by comprehensive...
Rhamnocitrin induces apoptosis of human nasopharyngeal carcinoma by inhibiting IGF-1R signaling pathway in vitro [0.03%]
Rhambocitrin通过抑制IGF-1R信号通路诱导人类鼻咽癌细胞凋亡
Yan-Yuan Zhou,Ya-Zhou Li,Zhi-Qiang Liu et al.
Yan-Yuan Zhou et al.
This study explored rhamnocitrin's apoptotic effects on human nasopharyngeal carcinoma cell lines (CNE-2/C666-1) and underlying mechanisms. Following treatment with varying concentrations, cell proliferation, apoptosis, and protein expressi...
A network pharmacological target mendelian randomization study on the neuroprotective effects of active ingredients in mahuang fuzi xixin decoction for multiple sclerosis [0.03%]
基于麻黄附子辛夷汤活性成分的多发性硬化神经保护作用的网络药理学靶点孟德尔随机化研究
Wei-Jie Li,Chong-Lian Feng,Zhao-Yuan Nie et al.
Wei-Jie Li et al.
Mahuang Fuzi Xixin Decoction (MFX), a traditional Chinese medicine containing 44 volatile components (97.36% total oil), includes key compounds like α-terpenol (13.34%) and 1,2,3-trimethoxy-5-methyl-benzene (22.64%). Using network pharmaco...
Polyprenylated acylphloroglucinols from Hypericum attenuatum and their antidepressant activities [0.03%]
毛蕊香中抗抑郁活性的多戊聚烯取代茋化合物
En-Hui Zhang,Dan Liu,Yong Xiang
En-Hui Zhang
Three new polycyclic polyprenylated acylphloroglucinols, attenuatumines A-C (1-3), were ioslated from the 90% EtOH extract of the air dried aerial parts of Hypericum attenuatum. Structural elucidation of all the compounds was performed by s...
Four new phenolic compounds from stems and leaves of Hemerocallis citrina (Daylily) [0.03%]
黄花菜茎叶中的四种新的酚类化合物
Xiao-Xue Li,Han Yu,Shang-Hong Song et al.
Xiao-Xue Li et al.
Four new phenolic compounds, hemerodiphenylethanes A-D (1-4), along with eight known compounds methyl 2,4-dihydroxy-6-[2-(4-hydroxyphenyl) ethyl] benzoate (5), methyl 2,4-dihydroxy-6-(4-hydroxyphenethyl)-3-methylbenzoate (6), neochlorogenic...
Iridoid glycosides from the leaves of Paederia foetida and their antinociceptive activities [0.03%]
臭牡丹叶中的环烯醚萜苷及其镇痛活性研究
Yu-Feng Chen,Wei Gong,Xue Sun
Yu-Feng Chen
A chemical investigation on the leaves of Paederia Foetida resulted into the isolation of two new iridoid glycosides, paefoetines A and B (1 and 2). Structural elucidation of all the compounds was performed by spectral methods such as 1D an...