A novel pyrrolidine alkaloid and a novel isoflavone with anti-inflammatory activity from the tubers of Arisaema franchetianum [0.03%]
一种石南叶天南星块茎中的抗炎新吡咯啶生物碱及异黄酮成分
Wan-Qi Yang,Meng-Yuan Cui,Yun-Peng Qin et al.
Wan-Qi Yang et al.
Solanpyrrole B (1), a new pyrrolidine alkaloid and 5,7,4',5'-tetrahydroxy-6, 3'-dimethoxyisoflavone (2), a new isoflavone, along with 12 known compounds (3-14), were isolated from the tubers of Arisaema franchetianum. The chemical structure...
Apoptotic effect of carvacrol on different cancer cells and its potential as an active medicine ingredient [0.03%]
百里香酚的细胞凋亡效应及其作为潜在药物活性成分的可能性研究
Müge Musmula,Senem Akkoc
Müge Musmula
Apoptosis is the programmed death of cells that have lost their function, have been damaged, or are no longer needed in the organism. Genes that control this process are overexpressed in some tumors. Carvacrol, a terpenoid, has been shown t...
Design, synthesis and anti-tumor activity of oleanolic acid derivatives targeting EGFR [0.03%]
雷公藤内酯型茋类化合物的合成及活性研究
Yan-Qiu Meng,Li-Ming Liu,Dong-Ping Xu et al.
Yan-Qiu Meng et al.
With computer-aided drug design (CADD) technology, a total of 12 inhibitors of EGFR based on oleanolic acid (OA) derivatives were designed and synthesized with modification at C-3 and C-28 positions of OA. Their structures were confirmed by...
Synthesis and antitumor activity of silibinin derivatives targeting VEGFR [0.03%]
茋衍生物的合成及其对VEGFR靶向和抗肿瘤活性的影响
Lei Gao,Liang-Feng Zhang,Yan Li et al.
Lei Gao et al.
Totally 10 inhibitors of VEGFR based on silibinin derivatives were designed and synthesized with the modification on the hydroxyl group at C-3 and C-7 positions of silibinin through acylation, selective aminolysis, alkylation, oxidation, an...
New modified silybin derivatives: design, synthesis, and preliminary evaluation of antitumor activity [0.03%]
新的奥利茋衍生物的设计、合成及初步抗肿瘤活性评价
Yan-Qiu Meng,Chao-Hui Zhang,Dong-Ping Xu et al.
Yan-Qiu Meng et al.
Based on the molecular docking of Epidermal Growth Factor Receptor inhibitors and known small molecules, key amino acid fragments and active groups were analyzed through computer-aided drug design techniques. Subsequently, these active func...
Design, synthesis, and biological evaluation of bergapten derivatives as potent anti-pancreatic cancer agents [0.03%]
补骨脂内酯衍生物的抗胰腺癌活性研究
Ying Yue,Jia-Rong Liu,Nan Wang et al.
Ying Yue et al.
Bergapten, a natural product from Zanthoxylum bungeanum Maxim., exhibits anticancer, antibacterial, anti-inflammatory, and hypolipidemic effects. A derivative, FSG-Y5 showed potent activity against pancreatic cancer cells PANC-1 (IC50 = 2.3...
C19-Diterpenoid alkaloids from two plants of Aconitum sinoaxillare and Aconitum chasmanthum [0.03%]
来源于藏边乌头和大花乌头中的C19二萜类生物碱研究
Ling-Feng Tian,Mei-Zhen Ye,Ting-Ting Li et al.
Ling-Feng Tian et al.
Five new compounds (1-5) were isolated from the whole plants of two species of Aconitum, including two aconitine-type C19-diterpenoid alkaloids, sinoaxidines A (1) and B (2) and a franchetine-type C19-diterpenoid alkaloid, sinoaxidine C (3)...
Minor indoloquinolizidine monoterpene alkaloids from an aqueous extract of the hook-bearing stem of Uncaria rhynchophylla [0.03%]
钩藤带钩茎水提物中微量的吲哚喹喏里西啶单萜类生物碱
Jin-Qiu Ren,Xiao-Qiang Lei,Qing-Lan Guo et al.
Jin-Qiu Ren et al.
Six minor undescribed indoloquinolizidine monoterpene alkaloids, uncarrhynchophyllines F - K (1 - 6), were isolated from an aqueous decoction of the hook-bearing stems of Uncaria rhynchophylla (gou-teng). Their structures were determined by...
Diterpenoids from the soft coral Pachyclavularia violacea and their anti-inflammatory activities [0.03%]
紫珊瑚软珊瑚的二萜类化合物及其抗炎活性
Chen-Lu Du,Xue-Yao Zhao,Xiao Xiao et al.
Chen-Lu Du et al.
The detailed chemical investigation of the South China Sea soft coral Pachyclavularia violacea, led to the isolation and characterization of a new casbane-type diterpenoid, 7,8-epoxy-casbene (1), along with seven known compounds (2-8). Thei...
Xi Yang,Yong-Chun Gao,Ya-Ping Chen et al.
Xi Yang et al.
Three unreported pterocarpans, erystrictin D (1) and a pair of diastereoisomers, erystrictins E/F (2a/2b), along with fifteen known compounds (3-17) were isolated from Erythrina speciosa. Their structures were established by extensive spect...