Design, synthesis and anti-tumor activity of oleanolic acid derivatives targeting EGFR
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With computer-aided drug design (CADD) technology, a total of 12 inhibitors of EGFR based on oleanolic acid (OA) derivatives were designed and synthesized with modification at C-3 and C-28 positions of OA. Their structures were confirmed by 1H-NMR,13C-NMR and ... ...
