The predictive value of genetic variations in the vascular endothelial growth factor A gene in metastatic colorectal cancer [0.03%]
血管内皮生长因子A基因遗传变异在转移性结直肠癌中的预测价值
T F Hansen,K-L Garm Spindler,R F Andersen et al.
T F Hansen et al.
Single-nucleotide polymorphisms (SNPs) in the vascular endothelial growth factor A (VEGF-A) gene may have clinical implications. The aim of this study was to investigate the possible predictive value of the VEGF-A SNPs, in patients with met...
Functional characterization of eight human cytochrome P450 1A2 gene variants by recombinant protein expression [0.03%]
八种人CYP1A2基因多态性的重组蛋白表达及功能分析
B Brito Palma,M Silva E Sousa,C R Vosmeer et al.
B Brito Palma et al.
Inter-individual variability in cytochrome P450 (CYP)-mediated xenobiotic metabolism is extensive. CYP1A2 is involved in the metabolism of drugs and in the bioactivation of carcinogens. The objective of this study was to functionally charac...
The temporal relationship between ABCB1 promoter hypomethylation, ABCB1 expression and acquisition of drug resistance [0.03%]
ABCB1启动子低甲基化、ABCB1表达变化和耐药获得之间的时序关系研究
K Reed,S L Hembruff,J A Sprowl et al.
K Reed et al.
Induced expression of the Abcb1 drug transporter often occurs in tumors in response to chemotherapy. The role that epigenetic modifications within the ABCB1 promoter play in Abcb1 expression remains unclear. We selected MCF-7 cells for surv...
A genome-wide association study identifies new loci for ACE activity: potential implications for response to ACE inhibitor [0.03%]
ACE活性的全基因组关联研究鉴定出新的遗传位点：对ACE抑制剂反应的潜在影响
C-M Chung,R-Y Wang,J-W Chen et al.
C-M Chung et al.
Because angiotensin-converting enzyme (ACE) activity is implicated widely in biological systems, we aimed to identify its novel quantitative trait loci for the purposes of understanding ACE activity regulation and pharmacogenetics relating ...
Cyclooxygenases-1 and -2 differentially modulate leukocyte recruitment into the inflamed brain [0.03%]
环氧化酶-1和-2通过不同的方式调节白细胞向脑部炎症部位募集的作用机制研究
S-H Choi,S Aid,U Choi et al.
S-H Choi et al.
Peripheral leukocyte recruitment in neuroinflammatory conditions can exacerbate brain tissue damage by releasing cytotoxic mediators and by increasing vascular permeability. Cyclooxygenase (COX)-derived prostaglandins promote the migration ...
A pharmacogenetic study of docetaxel and thalidomide in patients with castration-resistant prostate cancer using the DMET genotyping platform [0.03%]
去势抵抗性前列腺癌患者使用DMET基因分型平台对多西他赛和thalidomide的研究
J F Deeken,T Cormier,D K Price et al.
J F Deeken et al.
The anticancer agent docetaxel shows significant inter-individual variation in its pharmacokinetic and toxicity profile. Thalidomide is an active anticancer agent and also shows wide pharmacological variation. Past pharmacogenetic research ...
Clinical Trial
The pharmacogenomics journal. 2010 Jun;10(3):191-9. DOI:10.1038/tpj.2009.57 2010
Functional analysis of intron 8 and 3' UTR variable number of tandem repeats of SLC6A3: differential activity of intron 8 variants [0.03%]
SLC6A3第8外显子和3′UTR的串联重复序列的功能分析：第8外显子变异体的不同活性分析
M Hill,R J L Anney,M Gill et al.
M Hill et al.
Association studies have found that variation in the dopamine transporter gene (SLC6A3) is important in the susceptibility to attention-deficit hyperactivity disorder (ADHD) and response to methylphenidate treatment. An understanding of the...
A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease [0.03%]
TOMM40变量长度多态性可预测晚发性阿尔茨海默病的发病年龄
A D Roses,M W Lutz,H Amrine-Madsen et al.
A D Roses et al.
The ɛ4 allele of the apolipoprotein E (APOE) gene is currently the strongest and most highly replicated genetic factor for risk and age of onset of late-onset Alzheimer's disease (LOAD). Using phylogenetic analysis, we have identified a po...
Weight gain related to treatment with atypical antipsychotics is due to activation of PKC-β [0.03%]
非典型抗精神病药物引起的体重增加与PKC-β活化有关
C Pavan,V Vindigni,L Michelotto et al.
C Pavan et al.
Atypical antipsychotics (APDs) are currently used in clinical practice for a variety of mental disorders such as schizophrenia, bipolar disorder and severe behavioral disturbances. A well-known disadvantage of using these compounds is a pro...
Effect of dopamine D3 receptor gene polymorphisms and clozapine treatment response: exploratory analysis of nine polymorphisms and meta-analysis of the Ser9Gly variant [0.03%]
多巴胺D3受体基因多态性与氯氮平治疗反应的关系：九个多态性的探索性分析及Ser9Gly变异的元分析
R Hwang,C Zai,A Tiwari et al.
R Hwang et al.
D2 blockade has been implicated in having a central role in antipsychotic response. However, treatment refractoriness, in spite of complete D2 blockade, as well as the efficacy of clozapine (CLZ) in a portion of this patient population, ind...
Meta-Analysis
The pharmacogenomics journal. 2010 Jun;10(3):200-18. DOI:10.1038/tpj.2009.65 2010