The temporal relationship between ABCB1 promoter hypomethylation, ABCB1 expression and acquisition of drug resistance
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Induced expression of the Abcb1 drug transporter often occurs in tumors in response to chemotherapy. The role that epigenetic modifications within the ABCB1 promoter play in Abcb1 expression remains unclear. We selected MCF-7 cells for survival in increasing d... ...
