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A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease

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The ɛ4 allele of the apolipoprotein E (APOE) gene is currently the strongest and most highly replicated genetic factor for risk and age of onset of late-onset Alzheimer's disease (LOAD). Using phylogenetic analysis, we have identified a polymorphic poly-T var... ...