Comparative analysis of point-of-care bedside cyp2c19-testing guided anti-platelet therapy versus conventional therapies for cardiovascular diseases: a systematic review and meta-analysis [0.03%]
基于护理点鸟苷酸环化酶活性床旁CYP2C19基因分型指导的抗血小板治疗与传统疗法治疗心血管疾病的比较分析：系统综述和meta分析
Mohammed Khattab,Mohamed Baguneid,George P Patrinos et al.
Mohammed Khattab et al.
Genetic variation in CYP2C19 is linked to variable efficacy in antiplatelet therapies like clopidogrel. Patients with CYP2C19*2 and *3 loss of function alleles show reduced enzyme function, leading to lower active drug levels and higher ris...
mLeveraging genetic correlations to prioritize drug groups for repurposing in type 2 diabetes [0.03%]
利用遗传相关性优先确定2型糖尿病药物再定位的药物组
Astrid Johannesson Hjelholt,Tahereh Gholipourshahraki,Zhonghao Bai et al.
Astrid Johannesson Hjelholt et al.
Type 2 diabetes (T2D) is a complex, polygenic disease with substantial health impact. Despite extensive genome-wide association studies (GWAS) identifying risk loci, therapeutic translation remains limited. We applied a Bayesian Linear Regr...
Genetic and pharmacokinetic factors associated with imatinib-induced toxicities in gastrointestinal stromal tumors [0.03%]
与胃肠间质瘤伊马替尼诱导的毒性相关的影响遗传和药代动力学因素
Wei Zhuang,Yi Zeng,Xinping Lin et al.
Wei Zhuang et al.
Imatinib is associated with significant toxicities, including myelosuppression, oedema, and hypersensitivity, with considerable interpatient variability. Pharmacokinetic and pharmacogenomic factors contribute, but comprehensive biomarkers a...
Mitochondrial DNA variants and susceptibility to anti-tuberculosis drug-induced liver injury in Korean patients [0.03%]
线粒体DNA变异与韩国结核病患者抗结核药物性肝损伤易感性的关联研究
Vinh Hoa Pham,Sang-Heon Kim,Young-Koo Jee et al.
Vinh Hoa Pham et al.
It has been proposed that mitochondrial DNA variations can affect mitochondrial function, increasing the risk of drug-induced liver injury. This study aims to explore the association between mitochondrial DNA (mtDNA) variants and anti-tuber...
Anna Shteto,Jawad Boulahfa,Adrien Etcheto et al.
Anna Shteto et al.
Predictive safety risk biomarkers for drug-induced liver injury (DILI) are critically needed to enhance patient risk stratification and minimize adverse outcomes. This study aims to identify genomic markers associated with increased mortali...
Evaluation of experiential teaching approaches to enhance pharmacy students' confidence and knowledge in pharmacogenomics [0.03%]
体验式教学在提升药学学生精准用药知识及自信度的效果评估研究
Ruby Soueid,Toni J F Michael,Pete Yeap et al.
Ruby Soueid et al.
Pharmacogenomic services are commonly pharmacist-led, yet pharmacists report poor knowledge and confidence in application. This study evaluated an experiential teaching approach to enhance students' confidence and knowledge in pharmacogenom...
Genome-wide screening of pharmacogenomic biomarkers in jordanian patients with genetic disorders [0.03%]
约旦遗传病患者药物基因组生物标志物的全基因组筛选
Yazun Jarrar,Nancy Hakooz,Dina Abu Hashem et al.
Yazun Jarrar et al.
Introduction: Pharmacogenomics (PGx) testing aims to identify the most appropriate drug and dose for individual patients based on their genetic profiles. In Jordan, patients with genetic disorders often use multiple medic...
Wrenda Teeple,Jeffrey A Shaman,Tootie Tatum et al.
Wrenda Teeple et al.
Serine-arginine protein kinase 1 (SRPK1) is under-expressed in mucinous colorectal cancer, and may mediate resistance to oxaliplatin [0.03%]
粘液性结直肠癌中丝氨酸/精氨?蛋白激酶1低表达并可能介导奥沙利铂耐药性
William P Duggan,Mohammedreza Azimi,Lyndsey Flanagan et al.
William P Duggan et al.
5-15% of all colorectal cancers (CRCs) are mucinous. Mucinous CRCs are associated with an inhibited response to standard adjuvant and neoadjuvant therapies. Serine-Arginine Protein Kinase 1 (SRPK1) is an enzyme, which modulates the activity...
An innovative model for pharmacogenomics critical results identification and intervention [0.03%]
一种用于药物基因组学关键结果识别和干预的创新型模型
Ryley Uber,Vanessa A Hayduk,Alison Flango et al.
Ryley Uber et al.
Pharmacogenomics (PGx) test results are returned variably across healthcare settings, which can lead to challenges particularly when results require immediate intervention to avoid adverse consequences. While several return of result models...