Effect of risperidone metabolism and P-glycoprotein gene polymorphism on QT interval in patients with schizophrenia [0.03%]
代谢和P-糖蛋白基因多态性对精神分裂症患者QT间期的影响
Y Suzuki,N Tsuneyama,N Fukui et al.
Y Suzuki et al.
Risperidone (RIS) is a frequently used efficacious psychotropic drug. However, it prolongs the QTc interval and may cause fatal arrhythmia. Little is known on the determinants of this RIS side effect. RIS is metabolized by CYP2D6, and is su...
The c.480C>G polymorphism of hOCT1 influences imatinib clearance in patients affected by chronic myeloid leukemia [0.03%]
hOCT1的c.480C>G多态性影响慢性粒细胞白血病患者的伊马替尼清除率
A Di Paolo,M Polillo,M Capecchi et al.
A Di Paolo et al.
The aim of the study was to investigate any possible influence of polymorphisms of transmembrane transporters human organic cation transporter 1 (hOCT1), ABCB1, ABCG2 on imatinib pharmacokinetics in 33 men and 27 women (median age and range...
A comprehensive functional and clinical analysis of ABCC2 and its impact on treatment response to carbamazepine [0.03%]
ABCC2的全面功能和临床分析及其对卡马西平治疗反应的影响研究
S Rädisch,D Dickens,T Lang et al.
S Rädisch et al.
At the blood-brain barrier, overexpression of the drug efflux transporter ABCC2 (also known as MRP2) has been proposed as a mechanism for impaired carbamazepine (CBZ) treatment response in epilepsy. However, investigation of the impact of A...
Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance) [0.03%]
CALGB 40101(联盟)研究中紫杉醇诱导的外周感觉神经病变的多基因遗传性受轴突生长基因簇驱动
A Chhibber,J Mefford,E A Stahl et al.
A Chhibber et al.
Peripheral neuropathy is a common dose-limiting toxicity for patients treated with paclitaxel. For most individuals, there are no known risk factors that predispose patients to the adverse event, and pathogenesis for paclitaxel-induced peri...
Clinical Trial
The pharmacogenomics journal. 2014 Aug;14(4):336-42. DOI:10.1038/tpj.2014.2 2014
Prospective study of EGFR intron 1 (CA)n repeats variants as predictors of benefit from cetuximab and irinotecan in chemo-refractory metastatic colorectal cancer (mCRC) patients [0.03%]
表皮生长因子受体第1内含子(CA)n重复多态性预测西妥昔单抗联合伊立替康治疗二线以上转移性结直肠癌疗效的前瞻性研究
F Loupakis,C Antoniotti,C Cremolini et al.
F Loupakis et al.
The number of CA tandem repeats (CA)n in a highly polymorphic region of EGFR (epidermal growth factor receptor) intron 1 may affect gene transcription; the potential impact of allelic variants on the efficacy of cetuximab in metastatic colo...
A rare loss-of-function SCN5A variant is associated with lidocaine-induced ventricular fibrillation [0.03%]
一种罕见的SCN5A失活变异与利多卡因诱导的室颤相关
Q Xiong,L Cao,J Hu et al.
Q Xiong et al.
The human genome contains over 4 million variant sites, as compared with the reference genome, including rare sequence variants, which have the potential to exert large phenotypic effects, such as susceptibility to drug toxicity. We report ...
Copy number variants and therapeutic response to antidepressant medication in major depressive disorder [0.03%]
抑郁症患者中基因拷贝数变异与抗抑郁药的治疗反应之间的关系研究
K E Tansey,J J H Rucker,D H Kavanagh et al.
K E Tansey et al.
It would be beneficial to find genetic predictors of antidepressant response to help personalise treatment of major depressive disorder (MDD). Rare copy number variants (CNVs) have been implicated in several psychiatric disorders, including...
Gene-based association identifies SPATA13-AS1 as a pharmacogenomic predictor of inhaled short-acting beta-agonist response in multiple population groups [0.03%]
基于基因的关联分析鉴定出SPATA13-AS1为短效β受体激动剂吸入反应的药理基因组预测因子
B Padhukasahasram,J J Yang,A M Levin et al.
B Padhukasahasram et al.
Inhaled short-acting beta-agonist (SABA) medication is commonly used in asthma patients to rapidly reverse airway obstruction and improve acute symptoms. We performed a genome-wide association study of SABA medication response using gene-ba...
Serotonin toxicity from antidepressant overdose and its association with the T102C polymorphism of the 5-HT2A receptor [0.03%]
五羟色胺受体多态性与抗抑郁药过量中毒的关系研究
J M Cooper,D A Newby,I M Whyte et al.
J M Cooper et al.
Serotonin toxicity results from serotonin excess in the central nervous system from serotonergic drugs. Previous studies suggest an association between T102C polymorphism of the serotonin 2A (5-hydroxytryptamine 2A) receptor gene and seroto...
Building pharmacogenetics into a pharmacovigilance program in Singapore: using serious skin rash as a pilot study [0.03%]
遗传药理学在新加坡药物警戒项目中的建立——以重症皮疹为例的试点研究
D S L Toh,L L Tan,D C W Aw et al.
D S L Toh et al.
To study the possible genetic associations with adverse drug reactions (ADR), the Singapore Health Sciences Authority (HSA) has piloted a program to collect DNA and phenotype data of ADR cases as part of its pharmacovigilance program. Betwe...