Effect of risperidone metabolism and P-glycoprotein gene polymorphism on QT interval in patients with schizophrenia
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Risperidone (RIS) is a frequently used efficacious psychotropic drug. However, it prolongs the QTc interval and may cause fatal arrhythmia. Little is known on the determinants of this RIS side effect. RIS is metabolized by CYP2D6, and is subject to drug efflux... ...
