Revisiting Pluripotency Acquisition: A Unified Framework for Reprogramming Strategies [0.03%]
重新审视多能性获取：重编程策略的统一框架
Anamika Datta,Kunimasa Ohta
Anamika Datta
The traditional hierarchical view of totipotent cells generating diverse lineages of terminally differentiated cells was challenged by the discovery of induced pluripotent stem cells (iPSCs). This breakthrough demonstrated that the ectopic ...
Quantitative In Vivo Imaging of ATP Dynamics in Drosophila Using the Ratiometric Biosensor QUEEN [0.03%]
利用比值型生物传感器QUEEN对活体果蝇体内ATP动态的定量成像研究
Yuhan Luo,Sayaka Sekine,Naoto Kasahara et al.
Yuhan Luo et al.
Genetically encoded ATP biosensors enable monitoring of cellular energy status, but their application in multicellular organisms remains limited. QUEEN is a ratiometric ATP biosensor consisting of a bacterial ATP-binding protein fused to a ...
AID-Mediated Protein Knockdown Reveals the Requirement of NANOS2 in Prenatal Gonocytes for Establishing Functional Spermatogonial Stem Cells [0.03%]
NANOS2基因敲低揭示其在胎盘期生殖细胞中的作用及对建立功能性精原干细胞的重要性
Yumiko Saga,Quan Wu
Yumiko Saga
The RNA-binding protein NANOS2 plays a crucial role in male gonocyte development and the maintenance of spermatogonial stem cells. In the absence of the Nanos2 gene (Nanos2-KO), germ cells fail to enter G0 arrest and initiate the male diffe...
Replicative Neuromast Regeneration in Response to Injury in Pleurodeles waltl [0.03%]
壁虎肋槽鲟受伤后的复制性感觉神经元再生
Shinichi Hayashi,Ryohei Seki-Omura,Yuki Sato et al.
Shinichi Hayashi et al.
The lateral line is a mechanosensory organ found in cyclostomes, teleosts, and amphibians. Hair cells within its neuromasts have kinocilia and stereocilia that sense water flow, and the lateral line nerve transduces this sensory input. Hair...
Atypical Cadherin Fat2 is Involved in Axogenesis of Cerebellar Granule Cells in Zebrafish [0.03%]
斑马鱼铁蛋白2参与小脑颗粒细胞轴突发育
Jui Chun Wang,Miki Takeuchi,Ryuji Dohaku et al.
Jui Chun Wang et al.
Fat2 is an atypical cadherin with a large extracellular domain containing multiple cadherin repeats. Although members of the Fat family have been implicated in organ development, the role of Fat2 in neural development remains poorly underst...
Sbno1 and Usp8 Cooperate to Enhance Notch Signaling in Regulating Neural Stem Cells [0.03%]
Sbno1和Usp8通过增强Notch信号通路调控神经干细胞
Oyunchimeg Naranbaatar,Dai Ihara,Hidenori Tabata et al.
Oyunchimeg Naranbaatar et al.
The Notch signaling pathway is essential for the self-renewal, differentiation, and maintenance of neural stem cells (NSCs). While genetic studies in Drosophila have implicated Strawberry Notch in Notch signaling, the role of its vertebrate...
Computer-Aided Sperm Analysis Protocol for Evaluating Sperm Motility in Japanese Medaka [0.03%]
用于日本鲤鱼精子活力评价的计算机辅助精子分析方案
Miwa Kuroyanagi,Satoshi Ansai,Keigo Okamoto et al.
Miwa Kuroyanagi et al.
Changes in sperm motility can serve as an early indicator of reproductive effects caused by environmental chemicals or genetic perturbations. However, sperm motility is highly sensitive to external factors such as osmolarity, ionic composit...
Cooperative Roles of Pds5a and Pds5b Constrain Long-Range Chromatin Interactions in Vertebrate Embryos [0.03%]
Pds5a和Pds5b协同作用制约脊椎动物胚胎中的长程染色质相互作用
Shinra Ikeda,Hiroyuki Takeda,Ryohei Nakamura
Shinra Ikeda
Three-dimensional (3D) genome organization is dynamically restructured during early vertebrate development, yet how chromatin domains are established remains poorly understood. In particular, the contribution of individual cohesin regulator...
Derepression of a Subset of Meiotic Proteins in Primordial Germ Cells of max Mutant Zebrafish [0.03%]
最大突变斑马鱼原始生殖细胞中一组 mei 蛋白的去抑制作用
Yuya Hasegawa,Toshihiro Kawasaki,Yukiko Imai et al.
Yuya Hasegawa et al.
Germ cells in zebrafish are specified by a preformation mechanism, unlike in mice. Max (Myc associated factor X) and its associated PRC1.6 (polycomb repressive complex 1.6) act as negative regulators of germ cell- and meiosis-related genes ...
Convergence of Cell Biology and Developmental Biology: A Report of the Joint Meeting of the 77th JSCB and the 58th JSDB [0.03%]
细胞生物学和发育生物学的融合：第77届JSCB与第58届JSDB联合会议报告
Asuka C Kido,Tatsushi Igaki
Asuka C Kido
The Joint Meeting of the 77th Japan Society for Cell Biology (JSCB) and the 58th Japan Society of Developmental Biologists (JSDB) was held from July 16 to 18, 2025, in Nagoya, Japan. With the goal of fostering discussion across disciplinary...