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Derepression of a Subset of Meiotic Proteins in Primordial Germ Cells of max Mutant Zebrafish

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Germ cells in zebrafish are specified by a preformation mechanism, unlike in mice. Max (Myc associated factor X) and its associated PRC1.6 (polycomb repressive complex 1.6) act as negative regulators of germ cell- and meiosis-related genes in mice; however, th... ...