HMGCR genetic variability in Parkinson's disease in a Spanish cohort: associations with lipid metabolism and early onset [0.03%]
西班牙人群中帕金森病的HMGCR基因多态性与脂质代谢和早发的关系
Rafael Díaz-Belloso,Miguel Martín-Bornez,Daniel Macías-García et al.
Rafael Díaz-Belloso et al.
Lipid metabolism has emerged as a key factor in the pathophysiology of Parkinson's disease (PD). While 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), the rate-limiting enzyme in cholesterol biosynthesis, has been implicated in neu...
Altered gut microbiota mediates the association between APOE genotype and amyloid-β accumulation in middle-aged adults [0.03%]
APOE基因型与中年人脑内淀粉样蛋白β沉积的关系由肠道菌群介导
Yannick N Wadop,Rebecca Bernal,Wepnyu Y Njamnshi et al.
Yannick N Wadop et al.
Background: The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for Alzheimer's disease, yet the mechanisms linking APOE to amyloid-β (Aβ) pathology remain incompletely understood. Emerging evide...
Data-driven subtypes of subjective cognitive decline: neuropsychological profiles, Alzheimer's disease biomarkers, and clinical trajectories [0.03%]
基于数据的认知衰退亚型：神经心理学特征、阿尔茨海默病生物标志物和临床轨迹
Salvatore Mazzeo,Sara Boveri,Elisa Bortolin et al.
Salvatore Mazzeo et al.
Objectives: Subjective Cognitive Decline (SCD) is a heterogeneous condition recognized as the earliest manifestation of Alzheimer's disease (AD). We hypothesized that the heterogeneity of SCD may be synthesized in distinc...
Ataxia with oculomotor apraxia type 2: two pedigree studies and a comprehensive review [0.03%]
眼肌阵挛性共济失调二期的两项系谱研究及全面综述
Lang Yang,Sushuang Yang,Jianfei Liu et al.
Lang Yang et al.
Background: Ataxia with oculomotor apraxia type 2 (AOA2), a rare autosomal recessive neurodegenerative disorder, exhibits marked clinical heterogeneity, thereby presenting substantial diagnostic challenges. This study con...
Andrew J Larner
Andrew J Larner
Lazaros C Triarhou
Lazaros C Triarhou
Lazaros C Triarhou
Lazaros C Triarhou
José Ingenieros (1877-1925) [0.03%]
何塞·英格里埃罗斯
Martín Enrique Irribaren,Lazaros C Triarhou
Martín Enrique Irribaren
A spatial covariance 123I-5IA-85380 SPECT study of α4β2 nicotinic receptors in dementia with Lewy bodies [0.03%]
利瓦体痴呆α4β2尼古丁乙酰胆碱受体的立体定位放射自显影研究
Judith R Harrison,Sean J Colloby,John T O&#x;Brien et al.
Judith R Harrison et al.
Background: Cholinergic dysfunction, particularly involving nicotinic acetylcholine receptors (nAChRs), contributes to cognitive and psychiatric symptoms in dementia with Lewy bodies (DLB), yet spatial covariance patterns...
Lazaros C Triarhou
Lazaros C Triarhou