Transforming growth factor-β1 promotes initiation of entheseal pathological bone formation via osteonectin induction in ankylosing spondylitis [0.03%]
转化生长因子-β1通过诱导骨膜炎性骨形成启动中的osteonectin表达促进强直性脊柱炎发病机制发展
Sungsin Jo,Dongju Kim,Sung Eun Wang et al.
Sungsin Jo et al.
Ankylosing spondylitis (AS) is an inflammatory disease marked by aberrant new bone formation and spinal ankylosis. Transforming growth factor-β1 (TGFβ1) is implicated in osteogenesis, yet its downstream effectors in AS remain unclear. Ost...
E-cigarette vaping is associated with pro-fibrotic gene expression in kidney and liver tissues [0.03%]
电子烟雾化与肾脏和肝脏组织中促纤维化基因表达有关
Wanjun Gu,Howard Chang,Poorvi Saini et al.
Wanjun Gu et al.
Conventional tobacco use causes a wealth of diseases and adversely affects cells and organ systems across the body. The long-term effects of e-cigarette vaping on the same remain unclear. Identifying early pathogenic signals at the organ le...
Kinase regulation of miRNA networks in cardiometabolic disease: emerging pathways to precision therapy [0.03%]
心脏代谢疾病中激酶对miRNA网络的调控：通路精准治疗的新途径
Firdos Ahmad,Asima Karim,Meganathan Kannan et al.
Firdos Ahmad et al.
Cardiometabolic diseases remain a major global health burden, and current therapies only partially address the persistent residual risk driven by chronic inflammation, hypoxia, metabolic overload, and mechanical stress. A critical need is t...
Pressure-mediated mechanosensitive Piezo2 channel is activated in neurogenic bladder and promote bladder fibrosis in children [0.03%]
压力介导的机械敏感性Piezo2通道在神经源性膀胱中被激活并促进儿童膀胱纤维化
Lei Lv,Yanping Zhang,Qi Li et al.
Lei Lv et al.
Mechanosensitive Piezo2 channels play a critical role in bladder pressure perception and may contribute to bladder fibrosis in patients with neurogenic bladder (NB), a condition that significantly affects quality of life. This study aimed t...
γδ T cells show distinct responses to CMV after stem cell transplantation [0.03%]
造血干细胞移植后γδT细胞对CMV的免疫应答特征不同
Freya Sibbertsen,Zheng Song,Cedric Ly et al.
Freya Sibbertsen et al.
Cytomegalovirus (CMV) reactivation is a frequent complication after allogeneic hematopoietic stem cell transplantation (aHSCT) and critically shapes immune reconstitution. However, the clonal and functional dynamics of T cell responses to C...
Tumor-intrinsic TLR4 signaling as a context-dependent rheostat in glioblastoma [0.03%]
肿瘤内在的TLR4信号通路在胶质母细胞瘤中作用的研究进展
Thura Tun Oo
Thura Tun Oo
Glioblastoma (GBM) remains resistant to therapy due to cellular heterogeneity and adaptive stress responses, yet the role of tumor-intrinsic Toll-like receptor 4 (TLR4) signaling in this process remains unresolved. This review addresses a c...
Qian Guo,Yao-Zhao Li,Zhong-Ming Qian et al.
Qian Guo et al.
Under conditions of iron overload, increased non-transferrin-bound iron (NTBI) can gain access to cardiomyocytes, cause cardiac iron accumulation and generate reactive oxygen species which can result in iron-overload cardiomyopathy. Current...
Beyond the target: implications of Wnt pathway inhibitors on bone health [0.03%]
靶点之外：Wnt信号通路抑制剂对骨健康的潜在影响
Clement Nachef,Arnaud Vanjak,Eric Haÿ et al.
Clement Nachef et al.
Wnt signaling inhibitors are under investigation as potential therapies for conditions characterized by upregulated Wnt signaling, such as cancers, hematological disorders, and organ fibrosis. However, because the Wnt pathway is essential f...
Proteomic analysis reveals divergent inflammatory mechanisms of COVID-associated Guillain-Barré syndrome [0.03%]
蛋白质组分析揭示了与COVID相关的吉兰-巴雷综合征的炎症机制差异
Can Ulutekin,Amelie Can,Lenka Súkeníková et al.
Can Ulutekin et al.
Guillain-Barré syndrome (GBS) is an acute immune-mediated neuropathy triggered by infections, with poorly understood pathophysiological diversity. COVID-19-associated GBS (COVID-GBS) is a rare but severe post-infectious condition, and its ...
Integrative genetic and functional analysis of autosomal dominant hearing loss in 108 multigenerational families [0.03%]
108个多代家庭的常染色体显性遗传性听力损失的整合基因组和功能分析
Dominika Oziębło,Marcin L Leja,Nina Gan et al.
Dominika Oziębło et al.
Autosomal dominant hearing loss (ADHL) is a highly heterogeneous Mendelian disorder with numerous causative genes, yet large well-characterized European cohorts remain limited. We investigated 108 families of Polish origin with confirmed do...