Targeting EFEMP1 enhances chondrogenesis and inhibits hypertrophic differentiation in a spontaneous osteoarthritis mouse model [0.03%]
Yuhan Chang,Pei-Heng Jiang,Yung-Heng Hsu et al.
Yuhan Chang et al.
Osteoarthritis (OA) is a degenerative joint disease characterized by progressive cartilage degradation. EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) has been implicated in cartilage development and OA pathogenesis, as...
Diacerein improves liver fibrosis, steatosis, and atherosclerosis in ApoE knockout mice [0.03%]
Diacerein改善ApoE基因敲除小鼠的肝纤维化、脂肪变性及动脉粥样硬化病情
Jie-Eun Lee,Isom Jin,Jung-Jae Lee et al.
Jie-Eun Lee et al.
Non-alcoholic fatty liver disease and atherosclerosis may share a common pathogenesis involving chronic IL-1β-induced inflammation. We aimed to evaluate the efficacy of diacerein, an IL-1 pathway inhibitor, in improving liver fibrosis, ste...
Genetic analysis and reporting from whole-exome sequencing data in 1052 patients with intellectual disability [0.03%]
高外显率基因在1052例智力障碍患者中经全外显子测序分析及解读报告的临床意义
Xin Pan,Guanhua Qian,Li Liu et al.
Xin Pan et al.
Intellectual disability (ID) is a genetically heterogeneous neurodevelopmental disorder, with etiological diagnosis remaining challenging due to clinical phenotypes and genetic diversity. To investigate the diagnostic value of whole exome s...
Piezo1/PI3K-induced autophagy dysregulation in PDLSCs under mechanical stress during root resorption [0.03%]
根吸收过程中机械应力下Piezo1/PI3K诱导的PDLSCs自噬失调
Kuan Yang,Xiaoxi Lu,Qiang Zhang et al.
Kuan Yang et al.
This study aimed to clarify the mechanobiological mechanisms of physiological root resorption in deciduous teeth, focusing specifically on how mechanical stress influences autophagy in periodontal ligament stem cells (PDLSCs) via the Piezo1...
Lipids in kidney diseases: from systemic imbalance to intrarenal alterations of cellular lipid metabolism in rare and common kidney diseases [0.03%]
肾脏疾病中的脂质：从系统性失衡到罕见和常见肾病中细胞脂质代谢的改变
Carola Garavaglia,Alice Ossoli,Monica Gomaraschi
Carola Garavaglia
Chronic kidney disease (CKD) is expected to be the fifth cause of global mortality by 2040. Modifiable and non-modifiable risk factors for CKD range from metabolic conditions, such as diabetes or obesity, to genetic defects. Regardless of t...
Danka Cholujova,Nikoleta Csicsatkova,Zuzana Valuskova et al.
Danka Cholujova et al.
The CXCR4-CXCL12 axis is crucial for the interaction between malignant plasma cells (PC) and their microenvironment in multiple myeloma (MM). Here, we show that CXCR4 expression is upregulated in MM cell lines and PCs during both premaligna...
TFR2 p.A75V mutation aggravates liver iron overload in alcoholic liver disease via ERK pathway [0.03%]
TFR2 p.A75V突变通过ERK途径加重酒精性肝病的肝脏铁负荷过度现象
Chao Xie,Yingying Liu,Xiaofan Wang et al.
Chao Xie et al.
Liver iron overload, a contributing factor to liver damage, is frequently observed in advanced alcoholic liver disease (ALD). Genetic factors may influence the progression of ALD. This study explored the involvement of hemochromatosis-relat...
Bystander effects in photodynamic therapy-treated tumors involve spatiotemporally extended ferroptosis [0.03%]
光动力治疗诱导的肿瘤旁效应涉及时间和空间上延展的铁死亡
Mladen Korbelik,Albert W Girotti,David Kessel
Mladen Korbelik
The tumor bystander effect describes the ability of cells sustaining therapeutic treatment damage to transmit distress signals to neighboring unharmed cells and change their behavior. Photodynamic therapy (PDT), which uses light for activat...
Galectin-9 potentiates salivary gland damage by inducing ferroptosis in Sjogren's disease [0.03%]
唾液酸糖蛋白配体岩藻糖结合凝集素Galectin-9通过诱导自身免疫性分泌腺体铁死亡加重舍格伦综合征干眼病病理损伤
Fangyu Liu,Tiantian Deng,Yan Zhang et al.
Fangyu Liu et al.
Sjögren's disease (SjD), a systemic autoimmune disease, is characterized by exocrine glandular damage and hypofunction. The molecular mechanism of SjD was still unknown. Mendelian analysis was conducted to identify the targets. Clinical ch...
Spinal fluid antibody profile against bacteria demonstrates intrathecal antibody production in demyelinating diseases [0.03%]
脊柱液中的细菌抗体会在脱髓鞘疾病中产生脑内抗体反应
Emily E Polidoro,Nicholas Stosiek,Jon D Laman et al.
Emily E Polidoro et al.
This study follows work establishing multiple sclerosis (MS) microbial candidates from RNA sequencing of human brain samples. A subsequent study demonstrated anti-microbial immune responses in cerebrospinal fluid (CSF) of patients with demy...