Exhausted CD8+ T Cell in HIV Infection Exhibits an Impaired Bioenergetic Metabolism Driven by Mitochondrial Dysfunction [0.03%]
HIV感染中耗竭的CD8⁺T细胞表现出由线粒体功能障碍驱动的生物能量代谢受损
Yee Teng Chan,Kar Min Loh,Zhi Ying Phong et al.
Yee Teng Chan et al.
In people living with HIV (PLWH), persistent viral replication and antiretroviral therapy (ART)-associated toxicity contribute to T cell exhaustion, characterised by significant metabolic reprogramming that negatively impacts cellular funct...
ERAP1 Allotypes 2 and 10 Differentially Regulate the Immunopeptidome of Melanocytes [0.03%]
ERAP1-allotype 2和10通过不同的方式调节黑色素细胞的免疫肽组学
Martha Nikopaschou,Martina Samiotaki,Anna Kannavou et al.
Martha Nikopaschou et al.
Endoplasmic reticulum aminopeptidase 1 (ERAP1) is a polymorphic enzyme that shapes the peptide repertoire presented by MHC class I molecules and can regulate adaptive immune responses in cancer and autoimmunity. Common missense polymorphism...
Deubiquitinating Enzyme UCHL1 Modulates FHL2 to Block Ferroptosis and Counteract CD8+ T Cell Anti-Tumour Immunity in Lung Adenocarcinoma [0.03%]
脱泛素酶UCHL1通过调节FHL2抑制肺腺癌铁死亡并拮抗CD8+T细胞的抗肿瘤免疫反应
Xianchao Chen,Jinping Li,Bo Tang et al.
Xianchao Chen et al.
A pivotal strategy in immuno-oncology is the initiation and modulation of adaptive immune responses. Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1), known for its role in protein homeostasis and functionality, is implicated in tumorigenes...
Mycobacterium tuberculosis Acr1 Protein Mitigates Experimental Autoimmune Encephalomyelitis Symptoms by Generating Myeloid-Derived Suppressor Cells and Regulatory T Cells [0.03%]
Mycobacterium tuberculosis Acr1蛋白通过生成髓源性抑制细胞和调节性T细胞缓解实验性自身免疫性脑脊髓炎症状
Taruna Lamba,Mohammad Adeel Zafar,Mohammad Shaaz et al.
Taruna Lamba et al.
Mycobacterium tuberculosis (Mtb) effectively suppresses host immunity to ensure its survival. We have earlier shown that the Acr1 protein of Mtb can inhibit the differentiation of dendritic cells (DCs). Consequently, in the current study, w...
Nbeal2 Inactivation Triggers Abl1 Stabilisation and Dysregulated Subcellular Localisation of the Multi-Drug-Resistant Protein MDR1 (ABCB1) in Mast Cells [0.03%]
Nbeal2失活触发Abl1稳定化及肥大细胞多药耐药蛋白MDR1（ABCB1）亚细胞定位异常
Raphaela Marquardt,Nico Andreas,Ronja Herrnberger et al.
Raphaela Marquardt et al.
Inactivation of the BEACH (beige and chediak-higashi) family member NBEAL2 in humans and mice results in the development of the gray platelet syndrome (GPS), a bleeding disorder characterised by macrothrombocytopenia and splenomegaly. On th...
Inhibition of Pyruvate Dehydrogenase Kinase 2 Alleviates Concanavalin A-Induced Acute Liver Injury by Regulating Myeloid-Derived Suppressor Cells [0.03%]
丙酮酸脱氢酶激酶2抑制通过调节髓系来源的抑制细胞缓解刀豆蛋白A诱导的急性肝损伤
Chunxia Li,Chenyu Li,Weiwei Zhai et al.
Chunxia Li et al.
Pyruvate dehydrogenase kinase 2 (PDK2) regulates glucose metabolism; however, its role in liver injury development is unknown. Therefore, this study aimed to explore the effects of PDK2 on liver injury using a concanavalin A (Con A)-induced...
Ana Luísa Areia,Jani Almeida,Vera Alves et al.
Ana Luísa Areia et al.
Pregnancy requires precise maternal immune adaptation to support fetal development while maintaining defense against external threats. Disruption of this balance can result in complications such as preeclampsia (PE), a major cause of matern...
Mohammad Javad Hayati,Javad Yaghmoorian Khojini,Fatemeh Khara et al.
Mohammad Javad Hayati et al.
Gamma delta (γδ) T cells represent a distinct group of lymphocytes capable of functioning in both pro-tumorigenic and anti-tumorigenic capacities inside the tumour microenvironment (TME). Their unique ability for MHC-independent recogniti...
Review
Immunology. 2025 Oct 14. DOI:10.1111/imm.70035 2025
Molecular Mediators of Metabolic Reprogramming in Cancer: Mechanisms, Regulatory Networks, and Therapeutic Strategies [0.03%]
癌症代谢重组分子介体：机制、调控网络及治疗策略
Sana Ahuja,Sufian Zaheer
Sana Ahuja
Metabolic reprogramming is a hallmark of cancer, enabling tumour cells to flexibly adapt to fluctuating microenvironmental conditions, sustain uncontrolled proliferation, and acquire resistance to conventional therapies. Tumour metabolism i...
Review
Immunology. 2025 Oct 8. DOI:10.1111/imm.70045 2025
LAG-3+ Regulatory T Cells Suppress Effector Function of T Cells and Allow Their Proliferation Into Regulatory T Cells [0.03%]
LAG-3⁺ 调节性T细胞抑制效应T细胞的功能并促进其向调节性T细胞增殖
Avijit Dutta,Shi-Chuen Miaw,Tse-Ching Chen et al.
Avijit Dutta et al.
LAG-3+ regulatory T cells suppress the effector but not the proliferative response of naïve cognate antigen-specific CD4+ T cells in vivo. The Th1, Th2, and Th17 machineries in the suppressed CD4+ T cells are impaired. Genomic study of the...