The Potential Function of Toxoplasma gondii in Tumour Immunotherapy [0.03%]
Toxoplasma gondii在肿瘤免疫治疗中的潜力作用
Jiexing Tan,Zi-Guo Yuan,Luodan Yang et al.
Jiexing Tan et al.
Immunotherapy has revolutionised the clinical treatment of many types of cancer, including immune checkpoint inhibitors, adoptive cell therapies, and tumour vaccines, which are capable of providing long-term clinical benefit in some patient...
Review
Immunology. 2026 May 10. DOI:10.1111/imm.70147 2026
Benchmarking Dendritic Cell Enrichment Methods Reveals Subset-Specific Recovery Biases [0.03%]
基准测定树突状细胞富集方法揭示亚群特异性回收偏差
Fanny Onodi,Enwono Eyoh,Lucile Massenet-Regad et al.
Fanny Onodi et al.
Dendritic cells (DCs) are rare in human blood, often requiring enrichment prior to analysis. Here, we benchmark commonly used pan-DC enrichment methods by comparing recovered DC subset composition to ex vivo references. While all approaches...
Novel Pathway for Intercepting Granular Exocytosis: A13 Engages APLNR to Drive FBXO28-Mediated Ubiquitination and Proteasomal Clearance of Rab27a in Allergic Inflammation [0.03%]
过敏性炎症中APLNR通过A13介导Rab27a的FBXO28泛素化及蛋白酶体降解的新通路拦截颗粒型胞外运输
Gaohui Wu,Yanyu Ye,Jiaqi Duan et al.
Gaohui Wu et al.
Allergic airway inflammation (AA) is primarily driven by the activation of mast cells and eosinophils, with granular exocytosis serving as a key source of pro-allergic mediators that amplify pathological responses. This unmet need highlight...
Linlin Che,Xueting Xie,Xiaoyu Yang et al.
Linlin Che et al.
Hepatocellular carcinoma (HCC) poses a formidable therapeutic challenge due to its high heterogeneity, frequent late-stage diagnosis, and chemoresistance. Natural killer (NK) cells are essential for immune surveillance, yet their quantity a...
Review
Immunology. 2026 Apr 28. DOI:10.1111/imm.70141 2026
Dual Functions of Treg in the Mucosal Barrier and Lung Cancer Microenvironment and Prospects for Targeted Therapy [0.03%]
黏膜屏障和肺癌微环境中的Treg的双重作用及靶向治疗前景
Jiaming Cui,Jingru Han,Yang Dai et al.
Jiaming Cui et al.
Lung cancer remains one of the most common and deadly malignancies worldwide, representing a process intimately associated with dynamic changes in the tumour immune microenvironment. The pulmonary mucosal barrier, which serves as the first ...
Review
Immunology. 2026 Apr 27. DOI:10.1111/imm.70140 2026
Characterization of T-Cell Ubiquitination in Melanoma and Development of a Risk Signature Using Single-Cell and Bulk RNA-Seq [0.03%]
黑色素瘤中T细胞泛素化的特征及基于单细胞和批量RNA测序的危险信号开发
Jianping Lu,Cheng Lin,Wei Gao et al.
Jianping Lu et al.
Cutaneous melanoma (CM) is an aggressive cancer where early intervention is crucial, but the prognostic role and mechanisms of ubiquitination-related genes (URGs) in immune regulation remain unclear. This study aimed to develop a URG-based ...
Dual TLR7/8 Activation by Dihydroxyimidazoquinoline Adjuvant Orchestrates NF-κβ-iNOS-Driven Th1 Immunity and Durable Protection Against Leishmania donovani [0.03%]
二氢氧咪唑喹啉佐剂通过激活TLR7/8协同调控NF-κB-iNOS驱动的Th1免疫及顽固性杜氏利什曼原虫感染防护作用
Shivani Thakur,Sandeep Kaur,Kushvinder Kumar et al.
Shivani Thakur et al.
Targeting Toll like receptors (TLRs) signalling represents a powerful approach to re-calibrate host immunity against intracellular pathogens. Among these, dual TLR7/8 agonists uniquely bridge innate and adaptive immune response through NF-...
Precision Glyco-Modulated GcMAF2.0 Targets CLEC10A to Bidirectionally Re-Wire Macrophage States: Cross-Species Evidence, Mechanistic Omics and Translational Horizons [0.03%]
精准糖基化调节的GcMAF2.0靶向CLEC10A双向重塑巨噬细胞状态：跨物种证据、机制组学和转化前景
Evgeny Pokushalov,Dmitry Kudlay,Sergey Bogachev et al.
Evgeny Pokushalov et al.
Macrophages orchestrate inflammation, tissue repair and tumour surveillance, yet macrophage-targeted strategies such as CSF1R inhibition, CD47 blockade or TLR7/8 agonists have so far yielded only modest, context-restricted benefit. The C-ty...
Review
Immunology. 2026 Mar 19. DOI:10.1111/imm.70132 2026
Inside Out: How Cellular Localisation Shapes cGAS Functions in Health and Disease [0.03%]
cGAS功能的细胞定位在健康与疾病中的作用机制研究
Jiaqi Wu,Yingying Zhou,Bo Zeng et al.
Jiaqi Wu et al.
The function of innate immune sensors is intricately shaped by their spatial distribution within cells. cGAS (cyclic GMP-AMP synthase), a key cytosolic DNA sensor, illustrates this principle through its unexpected localisation to diverse or...
Review
Immunology. 2026 Mar 18. DOI:10.1111/imm.70133 2026