Variation in Microbiome Composition and Faecal Metabolites Are Associated With Differential Susceptibility to DSS-Induced Colitis [0.03%]
肠道微生物组组成和粪便代谢物的差异与DSS诱导结肠炎的易感性有关
Jessica M Till,Orion D Brock,Elyza A Do et al.
Jessica M Till et al.
Variation in microbiome composition is linked to differences in intestinal immune phenotypes and can be leveraged to identify microbiome-driven contributions to phenotypes of interest. Furthermore, such variation has been associated with di...
Mass-Standardised Differential Antibody Binding to a Spectrum of SARS-CoV-2 Variant Spike Proteins: Wuhan, Alpha, Beta, Gamma, Delta, Omicron BA.1, BA.4/5, BA.2.75 and BA.2.12.1 Variants-Antibody Immunity Endotypes [0.03%]
针对新冠病毒变异株刺突蛋白的抗体结合差异性大规模标化研究：武汉、阿尔法、贝塔、伽马、德尔塔、奥密克戎BA.1、BA.4/5、BA.2.75和BA.2.12.1变异株-抗体免疫分型
Philip H James-Pemberton,Shivali Kohli,Jordan Twynham et al.
Philip H James-Pemberton et al.
A fully mass-standardised quantitative comparative analysis of the differential antibody binding to spike variant proteins to SARS-CoV-2 has been performed for the variants: Wuhan, Alpha, Beta, Gamma, Delta and the Omicron variants BA.1, BA...
MyD88 Deficiency Protects Mice From Experimental Autoimmune Encephalomyelitis by Influencing Both Dendritic Cells and T Cells [0.03%]
MYD88缺陷通过影响树突状细胞和T细胞保护小鼠免于实验性自身免疫性脑脊髓炎
Wen Si,Gaochen Zhu,Qianling Jiang et al.
Wen Si et al.
Dendritic cells (DCs) play a central role in both the development and maintenance of adaptive immunity by their ability to prime and regulate T cell function. These interactions between DCs and T cells are crucial to the pathogenesis of mul...
Interferon Regulatory Factor 2 (IRF2) Suppression Enhances Murine Cardiac Allograft Survival Through Immune Evasion [0.03%]
干扰素调节因子2通过免疫逃避增强小鼠心脏异体移植的存活率
Li Tian,Man Zhang,Yuliang Guo et al.
Li Tian et al.
Transplant rejection, primarily caused by the immune system's recognition of allografts, continues to pose a significant challenge to graft survival. Drawing inspiration from the function of interferon regulatory factor 2 (IRF2) in tumour i...
Microplastics in Allergic Rhinitis: Multimechanistic Drivers of Barrier Disruption and Immune Dysregulation [0.03%]
微塑料在过敏性鼻炎中的作用：屏障破坏和免疫失调的多机制驱动因素
Xu Zhang,Zhiqiang Zhang,Mengyuan Liu et al.
Xu Zhang et al.
Epidemiology and Genetics of Rheumatic Diseases Suggest a Constant Rate of DNA Damage as Underlying Cause [0.03%]
风湿病的流行病学和遗传学表明DNA损伤的恒定速率为潜在原因
Piet C de Groen
Piet C de Groen
The cause of rheumatic diseases is poorly understood; many appear to have a dominant inheritance with low, incomplete penetrance. A recent theory poses that all DNA is continuously damaged at a constant rate, causing a constant rate of muta...
SpaCBA-OVA Liposome Reprograms Immune Tolerance to Ameliorate Allergic Rhinitis via DC-T Cell Crosstalk [0.03%]
基于 SpaCBA-OVA 的脂质体通过 DC-T 细胞互作重编免疫耐受以改善过敏性鼻炎
Jinna Yang,Jinmei Xue,Lihua Mo et al.
Jinna Yang et al.
Allergic rhinitis (AR) is a prevalent immune disorder driven by Th2-polarised inflammation, with current therapies primarily providing symptomatic relief rather than addressing the underlying immune dysfunction. Allergen-specific immunother...
GPR56 Outperforms CD319 as a Discriminative Marker for CD4+ Cytotoxic T Lymphocytes and Is Elevated in Primary Sjögren's Syndrome [0.03%]
GPR56可作为CD4+细胞毒性T淋巴细胞的区分性标志物优于CD319且在原发性舍格伦综合征中高表达
Ziqi Xiong,Yiming Gao,Junru He et al.
Ziqi Xiong et al.
Cytotoxic T lymphocytes (CTLs), especially CD4+ CTLs, play a critical role in immune responses against infections and cancers. Nevertheless, the surface markers that define CD4+ CTLs remain incompletely characterised, which limits their dia...
Preventing Differentiation Towards Primitive Macrophages in Stem Cells With Down Syndrome [0.03%]
用干细胞预防唐氏综合征向原始巨噬细胞的分化
Koki Harada,Keiichi Ishihara,Sayaka Wakayama et al.
Koki Harada et al.
Down syndrome (DS) is characterised by delayed brain development and intellectual disabilities. Brain macrophages originate from primitive macrophages that arise from mesodermal cells in the yolk sac and play a role in brain development. Pr...
Targeting Neuropilin-1 to Enhance Immunotherapy in Melanoma: Reducing Peripheral Treg-Mediated Immunosuppression and Tumour Progression [0.03%]
靶向神经纤毛蛋白-1可增强黑色素瘤免疫治疗：减少外周Tregs介导的免疫抑制和肿瘤进展
Somlata Khamaru,Kshyama Subhadarsini Tung,Subhasis Chattopadhyay
Somlata Khamaru
Melanoma, a highly aggressive skin cancer, ranks fifth among Caucasians and has a high mutation rate. Despite advances in immunotherapy, over 40% of patients face immune-related side effects. Neuropilin-1 (NRP1), which is overexpressed in v...