SIRT6 Ameliorates Atherosclerosis by Inhibiting M1 Macrophage Polarisation Through Deacetylated-TLR4 [0.03%]
SIRT6通过去乙酰化TLR4抑制M1型巨噬细胞极化从而改善动脉粥样硬化
Jian Huang,Huiming Yi,Yanhui Wu et al.
Jian Huang et al.
Atherosclerosis serves as the fundamental pathological process underlying numerous cardiovascular disorders, and the change of macrophage polarisation is the key to regulate the inflammatory response of AS. SIRT6 plays a protective effect i...
Blood Immunopathology of Tuberculosis Patients Disrupts Monocyte-Dependent T-Cell Activation and Cytokine Expression [0.03%]
结核病患者的血液免疫病理损害单核细胞依赖的T细胞活化和细胞因子表达
Joseph F Arthur,Hubert S Ahor,Monika M Vivekanandan et al.
Joseph F Arthur et al.
Pulmonary tuberculosis in humans is characterised by features of immunopathology, which influence both antimycobacterial therapy and the long-term prognosis. In the blood of tuberculosis patients, immunopathology manifests itself in reduced...
Gut Microbiota-Induced CTLA4 Expression on CD8+ T Cells Impairs Antitumor Immunity and Promotes Colorectal Cancer Progression [0.03%]
肠道微生物诱导的CTL抗体CD8阳性T细胞表达抑制抗肿瘤免疫并促进结直肠癌进展
Meidie Cheng,Shuangcheng Zhi,Mengmeng Zheng et al.
Meidie Cheng et al.
This study reveals a novel gut microbiota-CD8+ T cell axis driving immunosuppression in colorectal cancer. Analysis of 16S rRNA sequencing identified significant gut dysbiosis in CRC patients, with marked enrichment of Phocaeicola and Bacte...
STING Drives Psoriatic Inflammation by Promoting Neutrophil Recruitment and Facilitating NETosis [0.03%]
STING通过促进中性粒细胞募集和NET形成来驱动银屑病炎症
Haoyun Luo,Chenmin Hu,Tian Tian et al.
Haoyun Luo et al.
Psoriasis is a chronic, immune-mediated inflammatory disorder in which neutrophils are central to pathogenesis. While recent studies have implicated the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway in psoriasi...
A Bioluminescence Reporter Mouse Strain for In Vivo Imaging of IFNγ Cell Localization and Function [0.03%]
一种用于体内成像IFNγ细胞定位和功能的生物发光报告鼠品系
Yang Guo,Zhilan Yu,Siwei Fan et al.
Yang Guo et al.
Interferon gamma (IFNγ) is a pivotal inflammatory mediator and immune regulator, but its in vivo spatiotemporal dynamics and functional roles in inflammation and carcinogenesis remain incompletely understood. Here, we developed a C57BL/6J-...
Rochelle Y Benoit,Sheila Loshi,Craig S Moore
Rochelle Y Benoit
Bruton's Tyrosine Kinase (BTK) is a cytoplasmic kinase essential for B cell-mediated signalling, yet has also received recent recognition as a direct regulator of myeloid cell function. Beyond its established role in B cell malignancies, BT...
Review
Immunology. 2026 Feb 26. DOI:10.1111/imm.70126 2026
Monocyte-Derived Alveolar Macrophages in ALI/ARDS: The Core Drivers of Inflammation [0.03%]
急性肺损伤/急性呼吸窘迫综合征中的单核细胞源性肺泡巨噬细胞：炎症的核心驱动因素
Zhouli Tan,Yiwei Ding,Wei Chen et al.
Zhouli Tan et al.
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a deadly disorder with poor therapeutic opportunities, driven by dysregulated immunity. Here we position monocyte-derived alveolar macrophages (Mo-AMs) as central mediato...
Review
Immunology. 2026 Feb 23. DOI:10.1111/imm.70125 2026
Ahmed M E Abdalla,Yu Miao,Yasir A Taha et al.
Ahmed M E Abdalla et al.
Chimeric antigen receptor (CAR)-T cell immunotherapy shows significant success in hematologic malignancies. However, it faces critical challenges in solid tumours, such as suppressive tumour microenvironment (TME) and antigenic heterogeneit...
Review
Immunology. 2026 Feb 19. DOI:10.1111/imm.70124 2026
Resilient Biophysical Phenotype of Memory CD4+ T Cells in Long-Lived Mice [0.03%]
长寿小鼠记忆力CD4+_T细胞的稳健生物物理表型
Aldo Abarca-Ortega,Blanca González-Bermúdez,Judith Félix-Escalera et al.
Aldo Abarca-Ortega et al.
Age-related alterations in the immune system-collectively known as immunosenescence-include both quantitative and qualitative changes across various immune cell populations, including B cells, natural killer cells and T lymphocytes, affecti...
HIF1α Activates Glycolysis to Suppress Mycobacterium tuberculosis Growth in Mouse Bone Marrow-Derived Macrophages [0.03%]
缺氧诱导因子1α通过激活糖酵解抑制结核分枝杆菌的生长作用研究
Junghwan Lee,Jaewhan Kim,Ji-Ae Choi et al.
Junghwan Lee et al.
Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains a significant global health challenge due to the pathogen's ability to evade host immune responses and persist within macrophages. We investigated the metabolic changes in mo...