A PD1-CD137L Fusion Protein More Potently Enhances Anti-Tumour Immune Responses Than Targeting PD-L1 and CD137 Separately [0.03%]
PD1-CD137L融合蛋白比分别阻断PD-L1和刺激CD137更有力地增强抗肿瘤免疫反应
Runze Xia,Emily Pauline Nickles,Yu Mei et al.
Runze Xia et al.
Tumour immune evasion frequently involves PD-L1-mediated inhibition of T cell activity, limiting the efficacy of PD1/PD-L1 blockade, particularly in PD-L1-low or immunologically 'cold' tumours. To overcome this limitation, we developed a du...
Myo1g Mediates NKR-P1C Expression in Primary Mouse NK Cells and Participates in Cytotoxicity [0.03%]
Myo1g介导原代小鼠NK细胞中的NKR-P1C表达并参与细胞毒性作用
Héctor Romero-Ramírez,Vania Aminta Zuleica López-Esparza,Mariana Flores-Castelán et al.
Héctor Romero-Ramírez et al.
Myo1g, a short-tail class I myosin, has been extensively studied for its roles in cellular adhesion, migration, cytokine secretion and receptor recycling in T and B lymphocytes. However, its involvement in other immune cell populations, par...
MyD88-Family Adaptors: Compartmentalised Signalling and Non-Immune Functions [0.03%]
MyD88家族衔接蛋白：区室化信号转导及非免疫功能
Seshu Vardhan Pothabathula,Saurabh Mishra,Pugazhendhi Kannan et al.
Seshu Vardhan Pothabathula et al.
The myeloid differentiation primary response protein 88 (MyD88) family of Toll/interleukin-1 receptor (TIR) domain-containing adaptor proteins constitutes a central signalling hub that integrates innate immune sensing with tissue-specific s...
Review
Immunology. 2026 Aug 4. DOI:10.1111/imm.70184 2026
Metabolic Profiling of Circulating and Tumour-Infiltrating T Cells Uncovers Bioenergetic Checkpoints Linked With Immune and Clinical Skewing in Melanoma Patients [0.03%]
循环和肿瘤浸润T细胞的代谢轮廓分析揭示了黑色素瘤患者中与免疫和临床偏向相关的生物能量检查点
Hugo Brouque,Kareem Madhy,Stephane Mouret et al.
Hugo Brouque et al.
Metabolism is critical for immune cell functions. Tumours shape their microenvironment to render it metabolically hostile for infiltrating immune cells. While targeting immunometabolism emerges as a promising way to reinvigorate anticancer ...
Interleukin-18 Constrains the Intestinal Tuft Cell-Driven Responses During Helminth Infection [0.03%]
肠寄生虫感染期间，白细胞介素-18限制肠道毛细胞驱动的反应
Mengyuan Dai,Zhiqiang Yan,Xinyu Lei et al.
Mengyuan Dai et al.
Type 2 immunity at mucosal surfaces is essential for helminth clearance, tissue repair, and barrier maintenance, processes governed by a robust feed-forward circuit between chemosensory tuft cells and group 2 innate lymphoid cells (ILC2s). ...
The Gut Microbiota-Neuroimmune Axis Regulates Eosinophil Extracellular Traps and Their Role in Cancer Immunotherapy [0.03%]
肠道微生物群-神经免疫轴调节嗜酸性粒细胞胞外诱捕网及其在癌症免疫治疗中的作用
Yihao Wang,Hao Zhu,Wenchun Song et al.
Yihao Wang et al.
The gut microbiota functions as a metabolically active microbial ecosystem that engages in bidirectional communication with the host nervous and immune systems, thereby contributing to homeostasis and disease pathogenesis. Eosinophil extrac...
Review
Immunology. 2026 Aug 1. DOI:10.1111/imm.70181 2026
HMGB1-Induced Metabolic Rewiring of Macrophages via RAGE/MAPK Fosters Endocrine Resistance in Breast Cancer [0.03%]
通过RAGE/MAPK途径诱导的高迁移率组盒蛋白1代谢重编程促进乳腺癌内分泌耐药性
Donglin Liu,Shengnan Sun,Junning Peng et al.
Donglin Liu et al.
Endocrine resistance remains a critical challenge in hormone receptor-positive (HR+) breast cancer. The impact of the immune microenvironment on endocrine therapy efficacy is increasingly recognised, but its mechanisms are not fully underst...
A Look Ahead for Immunology [0.03%]
免疫学展望
Greg M Delgoffe
Greg M Delgoffe
Editorial
Immunology. 2026 Jul 28. DOI:10.1111/imm.70183 2026
Mapping of C5-Blocking Monoclonal Antibodies Reveals New C5 Inhibitory Epitopes and Novel Modes of C5 Inhibition [0.03%]
C5阻断单克隆抗体的图谱鉴定揭示了新的C5抑制表位和新颖的C5抑制模式
Rebekah Sian Cooke,Kok Yung Lee,Georgina Elizabeth Menzies et al.
Rebekah Sian Cooke et al.
C5 inhibition is a proven therapeutic target with several monoclonal antibody (mAb) and small molecule drugs in the clinic. To explore alternative modes of inhibition, novel C5-blocking mAbs were generated and compared to therapeutic mAbs e...
Comment on: Singh AK et al. From Radiation-Induced Immune Reprogramming to Globally Implementable Radio-Immunology [0.03%]
对Singh AK等人文章的评论：从辐射诱导的免疫重编程到全球可实施的放免学
Rajeev Kumar Jha,M Srikanth,M Vijayasimha
Rajeev Kumar Jha