LAG-3+ Regulatory T Cells Suppress Effector Function of T Cells and Allow Their Proliferation Into Regulatory T Cells
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LAG-3+ regulatory T cells suppress the effector but not the proliferative response of naïve cognate antigen-specific CD4+ T cells in vivo. The Th1, Th2, and Th17 machineries in the suppressed CD4+ T cells are impaired. Genomic study of the suppressed T cells ... ...
