Synthesis of Florasulam Stable Isotopes to Enable Identification of Degradants by Mass Spectrometry for Re-registration Studies [0.03%]
用于再注册研究中通过质谱技术鉴定氟磺胺降解产物的稳定同位素合成
Caroline Long,Lindsey G Horty
Caroline Long
Florasulam is a triazolopyrimidine herbicide that controls broadleaf and grass weeds in cereal crops and turf. It acts as an acetolactase synthase (ALS) inhibitor, blocking the synthesis of essential amino acids required for plant growth. D...
Synthesis and Evaluation of Radioiodinated [125I]7-Iodo-5H-Pyrido[4,3-B]Indole ([125I]CTAU) in Postmortem Human Alzheimer's Disease Brain [0.03%]
放射性碘化[125I]7-碘-5H-吡啶并[G，B-I]吲哚([125I]CTAU)的合成及在阿尔茨海默病脑组织中的评价研究
Chloe C McNamara,Agnes P Biju,Emma Lynn M Hipolito et al.
Chloe C McNamara et al.
The aim of this study was to further understand the tau imaging agent, flortaucipir (T807), by making small modifications and assess its effect on tau protein binding in Alzheimer's disease (AD). Thus, the fluoropyridyl group in T807 was re...
Radiolabeling of Trastuzumab With Technetium-99m [99mTc] as a Radioligand for Screening Mentha pulegium on HER-2 Receptors [0.03%]
使用Technetium-99m进行曲妥珠单抗的放射性标记，作为筛选薄荷婆婆纳中HER-2受体的放射配体
Narges Aryanpour,Golrokh Farnam,Farshad H Shirazi et al.
Narges Aryanpour et al.
The use of medicinal plants as anti-cancer agents has attracted the attention of researchers. A method is needed for screening the anti-cancer effects on HER-2 receptors. In this study, a simple method based on radioligand binding studies w...
Assessment of Stability Extrapolation for Carbon-14 Labelled Compounds for the Determination of Extended Retest Periods [0.03%]
用于确定延长复检周期的14C标记化合物稳定性外推评估
Antonio Moreno-Herrera,Ryan A Bragg,Charles S Elmore
Antonio Moreno-Herrera
Radiolabelled compound stability studies are an essential requirement to support human Absorption, Distribution, Metabolism and Excretion (hADME) clinical studies. This paper assesses the suitability of stability data extrapolation for carb...
Antibody Drug Conjugate Formation Using 2-14C-Iminothiolane: A Radiochemical Analysis of Sequential Lysine Conjugation, Uncloaking of a Phantom Drug-to-Antibody Ratio, and Stability of the ADC [0.03%]
使用2-14C-亚硫基乙醇的抗体药物偶联物的形成：连续赖氨酸连接、假药荷比及ADC稳定性的放射化学分析
Michael Wallace,Michael J Smith,John Brailsford et al.
Michael Wallace et al.
[14C]2-Iminothiolane ([14C]2-IT) served as a highly informative analytical tool to determine the rate of lysine thiolation and total addition of 2-IT to a monoclonal antibody. Specific activity measurements on [14C]2-IT modified mAbs found ...
Radiolabeled Aptamers for Bioimaging Applications in Oncology and Infectious Diseases [0.03%]
放射性标记的适配体在肿瘤和传染病的生物影像学中的应用
Najeeb Ullah,Tracy Ann Bruce-Tagoe,George Adu Asamoah et al.
Najeeb Ullah et al.
Radiolabeled aptamers are promising molecular probes for bioimaging because of their potential for high specificity, stability, and rapid clearance from nontarget tissues. They are single-stranded oligonucleotides labeled with radionuclides...
Synthesis and Characterization of 2-Thiophenemethanamine-2H5 Hydrochloride [0.03%]
2-噻吩甲胺-2H5盐酸盐的合成与表征
Sean David William Greenwood,Pete Deardorff,William Sherman et al.
Sean David William Greenwood et al.
Synthesis of the key building block, 2-thiophenemethanamine-2H5 hydrochloride, was achieved using mild conditions and purification methods in three steps from commercially available thiophene-2H4, with an overall yield of 61.6% and an overa...
Enhanced Control of Bacterial Wilt Disease in Tomato Plant via Transport and Penetration Tracking by Aid of 99mTc-Labeled Ralstonia solanacearum-Specific Bacteriophage [0.03%]
放射性标记噬菌体辅助野田放线杆菌运输和侵染追踪的番茄细菌性枯萎病的强化控制模型研究
Mohammed H Abdel-Aal,Yasmeen A Hasanien,Nahed A Younis et al.
Mohammed H Abdel-Aal et al.
In order to reduce the development of antibiotic and chemical resistance in bacterial phytopathogens like Ralstonia solanacearum, which causes bacterial wilt disease, bacteriophages are a safe and efficient biocontrol method. This research ...
Synthesis of BI 1584142 and BI 1810631 (Zongertinib), Two Potent HER2 Inhibitors, Labeled With Carbon-14 and With Deuterium [0.03%]
BI 1584142和BI 1810631（Zongertinib）两种有效的HER2抑制剂的碳-14和氘代标记合成
Bachir Latli,Eugene Chong
Bachir Latli
BI 1584142 (1) and BI 1810631 (2, zongertinib) are potent and selective HER2 tyrosine kinase inhibitors being developed for the treatment of non-small cell lung cancer. Carbon-14-labeled versions of these drug candidates were needed to stud...