Alexander Park,Robert M Edkins,June McCorquodale et al.
Alexander Park et al.
The synthesis of deuterated compounds is a major stumbling block in the field of neutron total scattering on disordered materials. This is due to the requirement for large quantities of pure sample with high deuterium content across all pos...
Synthesis of Potent Vanin-1 Inhibitors Labelled With Carbon-14 and Deuterium [0.03%]
标记有碳-14和重氢的 potent vanin-1抑制剂的合成
Bachir Latli,Matt Hrapchak,Ling Wu et al.
Bachir Latli et al.
Vanin-1 is an enzyme highly expressed in the kidneys, liver, and small intestines. Inhibition of this enzyme has been postulated as a novel approach in the treatment of several inflammatory diseases. BI 764122, BI 1585773, and BI 1595043 ar...
A 64Cu-Labeled Oxopurine Derivative for Translocator Protein-Targeted Inflammation Imaging [0.03%]
一种用于转运蛋白靶向炎症成像的64Cu标记的氧杂嘌呤衍生物
Undram Ochirsukh,Iqra Bibi,Ho Young Kim et al.
Undram Ochirsukh et al.
The translocator protein (TSPO) is a mitochondrial biomarker overexpressed in activated immune cells and various tumors that is an attractive target for positron emission tomography (PET) imaging of inflammation and the tumor microenvironme...
Fully Automated Production of Multiple 11C-Labeled PET Tracers Using a Self-Cleaning TracerMaker Radiosynthesizer [0.03%]
使用一种自清洁的放射合成器进行多种11C标记PET显影剂的全自动生产
Bao Hu,Wenchao Qu,Ramin Parsey et al.
Bao Hu et al.
The rapid translation of carbon-11 PET radiotracers into clinical and preclinical research requires automated synthesis modules capable of fast, reliable, and reproducible production. Here, we report the development and application of a ful...
Emily Murrell,Sahil Khan,Neil Vasdev
Emily Murrell
While conventional methods to 11C- and 18F-labelled radiopharmaceuticals utilize a vial-based approach, in the past quarter-century, a modern, efficient, and cleaner "loop method" has been developed. This Perspective will shed light on the ...
Development of a Fully Automated FASTlab 2 Process for [18F]AlF Radiolabelling of NOTA Peptide Conjugates [0.03%]
[18F]AlF非天然氨基酸配体标记的全自动FASTLAB 2工艺开发
Imtiaz Khan,Jon Shales,Stuart McCluskey et al.
Imtiaz Khan et al.
Aluminium[18F]fluoride ([18F]AlF) radiochemistry offers an attractive alternative to conventional radiometals for peptide and protein labelling and has been applied in several clinical radiopharmaceuticals. The method combines the broad ava...
Synthesis of Carbon-13 and Carbon-14 Labeled BI 690517 (Vicadrostat) and Its O-Glucuronide Metabolite BI 689875 [0.03%]
用于合成VICL和其O-葡糖苷酸代谢产物的C-13和C-14同位素标记物BI 690517及BI 689875的研究
Bachir Latli,Matt Hrapchak,Maxim Chevliakov et al.
Bachir Latli et al.
Vicadrostat, also known as BI 690517 (1) is a novel, potent, and selective aldosterone synthase CYP11B2 inhibitor being developed in combination with empagliflozin to slow the progression of kidney damage and reduce cardiovascular events in...
Radiotheranostics With Nanoparticles: Precision Targeting in Receptor-Overexpressing Tumors [0.03%]
受体高表达肿瘤的纳米颗粒放射治疗精确诊断：精准靶向
Evalyne J Cheruiyot,David M Wanjeh,John K Birir et al.
Evalyne J Cheruiyot et al.
Cancer remains one of the most challenging medical conditions. Nanotechnology is revolutionizing the approach to cancer management as an efficient tool for early diagnosis, therapy and monitoring. Nanoparticles (NPs) have shown promising re...
RETRACTION: Enhanced Control of Bacterial Wilt Disease in Tomato Plant via Transport and Penetration Tracking by Aid of 99mTc-Labeled Ralstonia solanacearum-Specific Bacteriophage [0.03%]
撤稿：利用99mTc标记的茄科拉尔森尼亚菌特异性噬菌体追踪其运输和渗透以增强番茄细菌性萎蔫病控制的方法
M. H. Abdel-Aal, Y. A. Hasanien, N. A. Younis, G. El Didamony, A. Askora, and G. Abdelaziz, "Enhanced Control of Bacterial Wilt Disease in Tomato Plant via Transport and Penetration Tracking by Aid of 99mTc-Labeled Ralstonia solanacearum-Sp...