Synthesis and Preclinical Evaluation of 99ᵐTc-HYNIC-Finasteride: A Novel SPECT Radiotracer Targeting 5α-Reductase in Prostate Cancer [0.03%]
新型前列腺癌5α-还原酶SPECT显像剂⁹⁹ᵐTc-HYNIC-非那雄胺的合成与药效学评价研究
Saba Shirin,Syed Qaiser Shah,Ralph Santos-Oliveira et al.
Saba Shirin et al.
We describe the synthesis and preclinical assessment of a novel technetium-99m-labeled 5α-reductase (5AR) inhibitor, a 5AR-targeting drug, a target enzyme of prostate cancer (PCa) pathology, as a SPECT imaging probe. Finasteride was attach...
Automated Manufacturing of Carbon-11 Radiopharmaceuticals Using Cassette-Based Radiosynthesizers [0.03%]
基于药盒的放射合成器全自动生产碳-11放射性药物
Michael L Schulte,Adam J Rosenberg
Michael L Schulte
As the field of radiochemistry moves toward the rapid development and translation of radiopharmaceuticals, the radiosynthetic methodology and manufacturing are becoming more and more refined. As the use of radiopharmaceuticals in clinical r...
Pei Su,Bin Dong,Lei Xu et al.
Pei Su et al.
A safe and economical synthetic method for one new carbon-14 labelled 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-[14C-pyrazolo]-1Hpyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one, [14C-pyrazolo]-Ibrutinib (2) was prepared with [14C]...
Recent Advances in 11C-Labeling With [11C]CO2 for PET Imaging [0.03%]
positron 发射断层扫描(PET) 成像中利用[11C]CO2进行11C标记的最新进展
Tianshuai Zhu,Jing-Jing Zhang,Lijun Tang et al.
Tianshuai Zhu et al.
Carbon-11 (11C)-labeled radiotracers are invaluable tools in positron emission tomography (PET), enabling real-time visualization of biochemical processes with high sensitivity and specificity. Among the various 11C synthons, cyclotron-prod...
Hypoxia Inducible Factor-1α Specific Probe for Tumor Hypoxia Positron Emission Tomography Imaging [0.03%]
基于缺氧诱导因子-1α的正电子发射断层显像肿瘤缺氧特异性探针研究
Qian Chen,Teli Liu,Xiaoyi Guo et al.
Qian Chen et al.
A peptide-based, hypoxia-inducible factor-1 α (HIF-1α) specific PET tracer for tumor hypoxia imaging is reported. It was prepared with a rapid Al18F labeling method with high stability. Al18F-CLLFVY specifically binds to HIF-1α with high...
Automated Radiosynthesis of [18F]FMeNER-D2 Using the Simplified One-Pot 18F-Fluoromethylation Method [0.03%]
简易的一锅法合成[18F]FMeNER-D2的自动化放射性合成方法
Kazunori Kawamura,Wakana Mori,Yusuke Kurihara et al.
Kazunori Kawamura et al.
(S,S)-2-(α-(2-[18F]Fluoro[dideutero]methoxyphenoxy)benzyl)morpholine ([18F]FMeNER-D2), which is used to image the norepinephrine transporter in the brain via positron emission tomography (PET), is typically radiosynthesized by O-fluorometh...
Influence of Activated Carbon on Fate of 14C-Sulfamethoxazole and 14C-Acetaminophen in Soil [0.03%]
活性炭对土壤中14C-磺胺甲恶唑和14C-扑热息痛 fate的影响
Kai Chen,Changfeng Yin,Juying Li
Kai Chen
In the present study, the influence of activated carbon (AC) on mineralization, degradation, extractable residues, and bound residue formation of 14C-sulfamethoxazole and 14C-acetaminophen was investigated. The results showed that AC facili...
Michal Kriegelstein,Aleš Marek
Michal Kriegelstein
Muscimol, a potent GABAA receptor agonist and psychoactive alkaloid found in Amanita mushrooms, is widely used as a tool compound in neurochemical research. Despite its importance, synthetic access to [3H]muscimol of high specific activity ...
99mTc-SNW-1 Nanoparticle Labeling and Its Biodistribution/Pathological Evaluations [0.03%]
99mTc-SNW-1纳米颗粒标记及其生物学分布和病理学评价
Setareh Derakhshan,Mehdi Shafiee Ardestani,Tahereh Zadeh Mehrizi et al.
Setareh Derakhshan et al.
This study aimed to evaluate the targeted diagnostic imaging and therapeutic applications of SNW-1 nanoparticles. The nanoparticles were synthesized using microwave technique and characterized in terms of size, zeta potential, morphology, a...
C14-Labelled Synthesis of Benalaxyl-M and Its Two Soil Metabolites [0.03%]
苯并噻二唑类杀菌剂苯咪唑醇-M的C14标记合成及其两土壌代谢物的鉴定
Entela Sinani,Stefano Garau,Francesca Rizzo et al.
Entela Sinani et al.
The radiosynthesis of the systemic fungicide for oomycete disease control Benalaxyl-M and its two most relevant soil metabolites was developed from the versatile common [phenyl-U-14C]N-(2,6-dimethylphenyl)-D-alanine methyl ester intermediat...