Assessing Dazhu Hongjingtian: Protection Against Acute Hypoxic Organ Damage and Analysis of Its Main Pharmaceutical Components [0.03%]
大朱红景天抗急性缺氧器官损伤作用评价及有效成分群研究
Chunyan Ou,Xia Gao
Chunyan Ou
Dazhu Hongjingtian (DZ), a traditional Tibetan medicine used for altitude sickness and blood stasis syndrome, currently lacks comprehensive pharmacological and quality control data. This study evaluated its antihypoxic effects in mice and e...
A Robust Stability-Indicating RP-HPLC Method for Simultaneous Determination of Widely Used Pharmaceutical and Cosmetic Preservatives [0.03%]
一种用于常用药品和化妆品防腐剂的同时测定的 robust 正相高效液相色谱法
Ramanjaneyulu Seemaladinne,Sudip Mandal
Ramanjaneyulu Seemaladinne
Pharmaceutical and cosmetic preservatives play a critical role in inhibiting microbial contamination, preventing chemical degradation, and maintaining product efficacy and safety throughout the shelf life. Given their functional importance,...
Trace Analysis of Genotoxic Impurity 3-Amino-N-Nitrosopiperidine in Alogliptin Benzoate by Ultra-Sensitive Liquid Chromatography Tandem Mass Spectrometry [0.03%]
超灵敏液相色谱-串联质谱法测定阿格列汀中基因毒性杂质3-氨基-N-硝基哌啶痕迹量残留的研究
Mithun M Gharat,Pallavi T Roy,Amit N Gosar et al.
Mithun M Gharat et al.
For many years, it is known as Nitrosamines are responsible for carcinogenicity in human. These nitroso-impurities were found detected in plastics, food items, cigarette, insect killer, water and alcoholic beverages. In 2018 EMA and USFDA c...
Ultra-Sensitive and Validated method for Trace Quantification of Carcinogenic Benzene in Cetirizine Dihydrochloride [0.03%]
特异性和验证性的定量方法测定赛庚啶中致癌苯微痕量杂质的研究
Mithun M Gharat,Pallavi T Roy,Amit N Gosar et al.
Mithun M Gharat et al.
Benzene (BENZ) is classified as a Class 1 residual solvent according to ICH Q3C guidelines due to its established classification as a Group 1 human carcinogen. During the chemical production of Cetirizine Dihydrochloride (CTZ) API, Cetirizi...
Development and Validation of Simultaneous Quantification of 6TGN and 6MMPN in Whole Blood Using LC-MS/MS: An Application to Therapeutic Drug Monitoring in Hematological Malignancies and in Inflammatory Bowel Diseases [0.03%]
一种同时定量全血中6TGN和6MMPN的LC-MS/MS方法的建立及其在血液系统恶性肿瘤及炎症性肠病治疗药物监测中的应用
Marie Allard,Nicolas Vignal,Aude Loiseau et al.
Marie Allard et al.
Thiopurine immunosuppressive drugs are indicated in children with acute lymphoblastic leukemia and in both children and adults with chronic inflammatory diseases. Therapeutic drug monitoring (TDM) of its DNA-incorporated metabolites 6-thiog...
Stable Isotope-Resolved Metabolomics in Elucidating Mitochondrial Metabolic Reprogramming and Therapeutic Targets [0.03%]
稳定同位素解析代谢组学在阐明线粒体代谢重编程和治疗靶点中的作用
Dan Yang,Xinyan Wu,Xiufang Luo et al.
Dan Yang et al.
Stable isotope-resolved metabolomics (SIRM) has emerged as a pivotal methodology for dissecting mitochondrial metabolic reprogramming and its connection to therapeutic targets. By combining isotopically labeled substrates with metabolic flu...
Zhuangdu Quhan Mixture Alleviates Ankylosing Spondylitis in Mice by Inhibiting the Interleukin-17 Signaling [0.03%]
庄独祛寒汤通过抑制白介素-17信号通路治疗小鼠强直性脊柱炎
Dan Liu,Yanrong Wei,Zijing Ge et al.
Dan Liu et al.
This study aimed to elucidate the therapeutic effect and mechanism of Zhuangdu Quhan Mixture (ZDQHM) in ankylosing spondylitis (AS). An AS mouse model was established in mice using β-glucan. Therapeutic efficacy was assessed through arthri...
Exploring GC-MS-Based Phytochemistry and Network Pharmacology to Elucidate the Multi-Target Therapeutic Potential of Betel Leaf Oil as an Analgesic and Anti-Inflammatory Agent [0.03%]
基于GC-MS的植物化学和网络药理学探究人蔴叶油作为镇痛和抗炎剂的多靶点治疗潜力
Shazia Parveen,Dinesh Kumar Yadav
Shazia Parveen
Betel leaf (Piper betle L.) has been widely used in traditional medicine for treating pain, inflammation, and microbial infections due to its rich phytochemical content. However, the molecular mechanisms underlying its analgesic and anti-in...
Study on the Warm Property Mechanism of Pro- HS and Its Separated Fractions Based on Metabolomics [0.03%]
基于代谢组学的补肾益气中药普济强身片及其拆方药对温性机制研究
Ajiao Hou,Chao Yu,Guoqing Shan et al.
Ajiao Hou et al.
The theory of medicinal properties of traditional Chinese medicine is the core guideline for syndrome differentiation and medication. Herba Siegesbeckiae (HS) is cold in property, and its medicinal property changes from cold to warm after p...
Integration of HPLC Amino Acid Profiling With AHP-CRITIC Guided Freeze-Drying Process Optimization, Chemical-Pharmacodynamic Equivalence, and Acute Toxicity Evaluation of Scorpio [0.03%]
高效液相色谱氨基酸分析与层次分析法-基于信息量的特征根方法引导的冷冻干燥工艺优化、化学药理等效性及全蝎急性毒性评价集成体系的研究
Wan Ziteng,Xue Xiao,Yang Zhen et al.
Wan Ziteng et al.
This study optimized the freeze-drying process of Scorpio, compared its chemical and pharmacodynamic equivalence with traditional salt-processed Scorpio in treating CIA model rats, established an equivalent conversion relationship, and eval...