Development and Validation of Simultaneous Quantification of 6TGN and 6MMPN in Whole Blood Using LC-MS/MS: An Application to Therapeutic Drug Monitoring in Hematological Malignancies and in Inflammatory Bowel Diseases
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Thiopurine immunosuppressive drugs are indicated in children with acute lymphoblastic leukemia and in both children and adults with chronic inflammatory diseases. Therapeutic drug monitoring (TDM) of its DNA-incorporated metabolites 6-thioguanine nucleotides (... ...
