Antibiotic Potency and Resistance: A Critical Review of Analytical and Microbiological Methodologies [0.03%]
抗生素效价与抗药性：分析和微生物学方法批判回顾
Trupesh Pethani,Hetal Suva,Janki Patel et al.
Trupesh Pethani et al.
Antibiotics are essential chemotherapeutic agents that inhibit or destroy pathogenic microorganisms, and their development from ancient natural remedies to the discovery of penicillin in 1928 revolutionized modern medicine. Multiple major c...
Development and Validation of Sensitive RP-HPLC Bioanalytical Method of Diclofenac Sodium and Its Predictive In-Silico Physiologically Based Pharmacokinetic Modeling in Hepatic and Renal Impairment [0.03%]
开发和验证Diclofenac钠的敏感RP-HPLC生化分析方法及其在肝肾功能不全中基于生理学的药代动力学模型的预测模拟研究
Mahrukh Zehravi,Muhammad Harris Shoaib,Rabia Ismail Yousuf et al.
Mahrukh Zehravi et al.
Diclofenac sodium is a widely prescribed NSAID for inflammatory and rheumatoid diseases, and the dose adjustment, especially for elderly patients suffering from renal or hepatic impairment, is not a routine practice. In this study, a sensit...
A Robust Stability-Indicating RP-HPLC Method for Quantification of Topiroxostat and Dotinurad: Method Development, Validation, and Degradation Studies [0.03%]
托匹羅oxidast和dotinurad的稳健稳定性指示RP-HPLC方法的开发、验证及降解研究
Md Al Imran Hossain,Mst Jesmin Aktar,Mehedi H Naim et al.
Md Al Imran Hossain et al.
The investigation developed a new stability-indicating reverse-phase high-pressure liquid chromatographic (RP-HPLC) assay method to quantify Topiroxostat and Dotinurad in pharmaceutical dosage forms. The technique used is isocratic elution ...
Purification of Double-Stranded RNA Impurities From In Vitro-Transcribed mRNA Using Size-Exclusion Chromatography [0.03%]
使用尺寸排阻色谱法从体外转录的mRNA中纯化双链RNA杂质
Kyle J Tynan,Trina Mouchahoir,Mark S Lowenthal et al.
Kyle J Tynan et al.
dsRNA is a highly immunogenic byproduct generated during in vitro transcription of mRNA, leading to unwanted immunostimulatory responses and reduced vaccine efficacy. Removal of dsRNA impurities from mRNA is challenging, as they share simil...
Development and Validation of a Stability-Indicating RS HPLC Method for Leuprolide Acetate and Its Related Substances: Characterization of Degradation Products With LC-MS [0.03%]
用于促黄体生成素释放激素-LDAC及其有关物质的稳定性指示剂反相HPLC法的建立与验证：LC-MS表征降解产物
Pydi Simhachalam,Thatituri Sabithakala
Pydi Simhachalam
A new stability-indicating related substance method was developed and validated for leuprolide acetate (LPA) and its related impurities and established the degradation profile for the LPA drug that was exposed to various stress conditions. ...
Determination of Coblopasvir in Mouse Plasma by Liquid Chromatography-Tandem Mass Spectrometry and Its Application to Pharmacokinetic Study [0.03%]
LC-MS/MS测定小鼠血浆中coboltasvir及其药动学研究
Zhongjie Shi,Yunhui Chen,Jinfang Jiang et al.
Zhongjie Shi et al.
This study aims to develop and validate a highly sensitive and high-throughput liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination of coblopasvir in mouse plasma and to apply it to a pharmacokinetic study....
Pharmacokinetic Characteristics of 6-Hydroxykaempferol-3,6-Diglucoside in Normal and Diabetic Cardiomyopathy Mice [0.03%]
6-羟基京尼 Rud 曲环酮-3,6-二葡萄糖苷在正常和糖尿病心肌病小鼠体内的药代动力学特征
Rui Yao,Fuxin Han,Xiaoju Zhang
Rui Yao
6-Hydroxykaempferol-3,6-diglucoside is an important flavonoid constituent of Carthamus tinctorius L., with potential antioxidant and myocardial protective effects. However, its pharmacokinetic characteristics in normal and diabetic cardiomy...
Correction to "Exploring the Pharmacological Mechanisms of Xiaochaihu Tang in Treating Postmenopausal Osteoporosis: A Study Based on Network Pharmacology and Experimental Validation" [0.03%]
小柴胡汤治疗绝经后骨质疏松症药理机制的补遗：基于网络药理学及实验验证的研究
Published Erratum
Biomedical chromatography : BMC. 2026;40(7):e70488. DOI:10.1002/bmc.70488 2026
Combining Online HPLC-ABTS Screening With Machine Learning to Predict the Bioactivity of Antioxidant Components in Pandani Tectorii Radix et Rhizoma [0.03%]
基于HPLC-ABTS联用筛选结合机器学习预测潘大尼根及根茎抗氧化成分生物活性
Shu-Zhen Chen,Yong-Lin Ma,Dong-Xiao Li et al.
Shu-Zhen Chen et al.
This study developed an online HPLC-ABTS method to screen antioxidant phenolic acids in Pandani tectorii radix et rhizoma (PT) from 20 geographical origins. Six common constituents were screened and assigned by standards: neochlorogenic aci...
Comprehensive Analytical Method Development for Related Substance Determination in Dorzolamide Hydrochloride-Timolol Maleate Ophthalmic Solutions: Multi-Method Approach and Regulatory Compliance [0.03%]
多佐胺盐酸盐-美开朗马来酸盐眼科溶液的全方位相关物质测定分析方法开发：多种方法途径及符合法规要求
Ramakrishna Kapavarapu,Srujan Kumar Mantena
Ramakrishna Kapavarapu
This study presents the development and validation of three selective chromatographic methods for the identification and quantification of related substances, including process-related impurities and degradation products, in combined ophtha...