Insights Influencing the Selection of Stable Isotopically Labeled Internal Standards (SIL-ISs) for LC-MS/MS Quantitative Assays [0.03%]
影响LC-MS/MS定量分析中选择稳定同位素内标(SIL-ISs)的因素及启示
Nuggehally R Srinivas,Raja Reddy Kallem,Michael G Bartlett
Nuggehally R Srinivas
Validated assays are vital to support the accurate reporting of pharmacokinetics for parent drug/metabolite(s), regardless of the stage of drug development. One of the recent nuances in the field has focused on the selection of an appropria...
Chromatography in Preparative/Industrial Scale Separation of Enantiomeric Mixtures [0.03%]
制备和工业手性拆分分离中的色谱法研究进展
Ravi Bhushan
Ravi Bhushan
Analytical chromatographic methods of enantioseparation do serve as good starting points, but the preparative scale requires more extensive method development and is yet facing challenges. There remains a clear opportunity to refine workflo...
An Isocratic RP-HPLC Method for Simultaneous Quantification of Nateglinide and Furosemide: Application to In Vitro Caco-2 Intestinal Permeability Studies of Nanodrugs [0.03%]
一种等梯度RP-HPLC法同时测定那格列奈和呋塞米的含量：用于纳米药物体外Caco-2肠上皮细胞模型渗透性研究的方法学应用
Fatima Khalifa Al-Sulaiti,Aysegul Dogan,Fatma Kir et al.
Fatima Khalifa Al-Sulaiti et al.
In the booming era of nanomedicines, Caco-2 intestinal permeability experimental models allow characterizing intestinal permeabilities of nanopharmaceuticals and are conducted in the presence of cell culture media (CCM) and stabilizers. Met...
Screening and Validation Serum Potential Biomarkers for Intrahepatic Cholestasis of Pregnancy Comparison to Healthy Controls by 1H-NMR and UPLC-MS/MS [0.03%]
基于1H-NMR和UPLC-MS/MS技术筛选并验证妊娠期肝内胆汁淤积症血清潜在标志物及其与正常孕产妇的比较研究
Yufeng Deng,Jiayi Wang,Dujuan Zhan et al.
Yufeng Deng et al.
The diagnosis of intrahepatic cholestasis of pregnancy (ICP) is indeed a challenging clinical issue due to its complex etiology and the need for accurate diagnostic markers. In this study, proton nuclear magnetic resonance spectroscopy (1H-...
Comprehensive Analysis of Bioactive Phytoconstituents in Red Flesh of Dioscorea opposita Thunb. by UHPLC-Q-Orbitrap-HRMS [0.03%]
基于UHPLC-Q-Orbitrap-HRMS的何首乌红色肉质中的活性次生代谢产物分析研究
Lanping Yang,Wendi Wang,Zhenzhen Liu et al.
Lanping Yang et al.
Dioscorea opposita Thunb. cv. Tiegun (DTT) is used daily as food and medicine. However, there is confusion in removing the red flesh of DTT (RF), as the nutrient phytochemicals of RF are unclear. This study aimed to reveal the phytochemical...
LC-MS/MS-Based Serum Lipidomic Profile to Reveal Cancer-Specific Biomarkers for Renal Cell Carcinoma [0.03%]
基于LC-MS/MS的血清脂质组谱揭示肾细胞癌特异性生物标志物
Lin Lin,Jiaxin Zheng,Sixia Hu
Lin Lin
Renal cell carcinoma (RCC) is one of the most lethal malignant tumors in the urinary system, and its incidence rate is increasing in the last decade. Discovering sensitive and specific biomarkers for RCC and exploring its pathogenesis are o...
Detection of Pesticide Residues in Fruits and Vegetables Involving Different Chromatographic Techniques (LC-MS/MS, GC-MS/MS, GC and HPLC) [0.03%]
几种色谱技术联用检测水果和蔬菜中农药残留
Ishrat Jan,Fehmida Rashied,Naveed A Malik et al.
Ishrat Jan et al.
The rampant use of pesticides in agricultural practices poses significant risks to human health and the environment. To mitigate these risks, regulatory authorities enforce stringent measures to monitor and control pesticide residues in foo...
Evaluation of Anlotinib Metabolic Stability in HLMs Matrix Applying Ultra-Fast UPLC-MS/MS Approach: Greenness Assessment With In Silico Testing for Structural Alarms Related to the Metabolic Lability and DEREK Toxicity [0.03%]
基于超快速UPLC-MS/MS方法评价阿帕替尼在人肝微粒体基质中的代谢稳定性并运用计算机软件预测其结构警戒结构及毒性危险性指标
Mohamed W Attwa,Ali S Abdelhameed,Adnan A Kadi
Mohamed W Attwa
Anlotinib (Focus V) is approved by the China Centre for Drug Evaluation in 2018 as a third-line treatment for patients with certain advanced cancers. This study aimed to develop a specific, fast, reliable, and sustainable ultraperformance l...
Metabolic Profile In Vivo and Potential Mechanisms of Danggui Jianzhong Decoction Against Gastric Ulcer by Ultra-High-Performance Quadrupole Time-of-Flight Mass Spectrometry Combined With Network Pharmacology Analysis [0.03%]
当归建中汤防治胃溃疡的体内代谢谱及机制研究联合超高分辨率四极杆飞行时间质谱与网络药理学分析研究
Tian-Hua Duan,Xiao-Ya Jiang,Ze-Zhao Zhang et al.
Tian-Hua Duan et al.
This study employed an integrated approach that combined ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) with network pharmacology to systematically characterize the phytochemical compone...
Liquid Chromatography-Mass Spectrometry Method for the Estimation of Tacrolimus From Whole Blood Using Novel Time Programming Coupled With Diverter Valve Plumbing to Overcome the Matrix Effect [0.03%]
一种定量测定全血他克莫司浓度的液相色谱-质谱法及其矩阵效应克服方法：采用新型时间编程与切换阀连接的新方法
Sajad Khaliq Dar,Arshad H Khuroo,Mohd Akhtar et al.
Sajad Khaliq Dar et al.
Tacrolimus is an immunosuppressant commonly used for the prevention of allograft rejection in transplant patients. Liquid chromatography mass spectrometry (LC-MS/MS) method was successfully developed and validated for the estimation of tacr...