Ciliated cells promote high infectious potential of influenza A virus through the efficient intracellular activation of hemagglutinin [0.03%]
纤毛细胞通过高效激活血凝素促进高致病性的甲型流感病毒感染
Zijian Guo,Victoria S Banas,Yuanyuan He et al.
Zijian Guo et al.
Influenza viruses utilize host proteases to activate the viral fusion protein, hemagglutinin (HA), into its fusion-competent form. Although proteolytic activation of HA is essential for virus replication, the cell-type dependence of HA acti...
Caspase cleavage of Kaposi sarcoma-associated herpesvirus proteins: a role for K5 in preventing caspase-mediated cell death during lytic replication [0.03%]
卡波西肉瘤疱疹病毒蛋白的半胱氨酸蛋白酶切割：K5蛋白通过防止裂解性复制期间的半胱氨酸蛋白酶介导的细胞死亡发挥作用
David A Davis,Yana Astter,Emma N Treco et al.
David A Davis et al.
Viral infections lead to caspase activation as a cellular defense response. Some viruses overcome this response by encoding viral proteins that undergo caspase cleavage and, by various mechanisms, aid in cell survival. Kaposi sarcoma-associ...
Organoids: physiologically relevant ex vivo models for viral disease research [0.03%]
类器官：病毒疾病研究的体外生理模型
Yijing Wang,Dingkun Peng,Meilin Li et al.
Yijing Wang et al.
Viral diseases pose serious threats to human health, resulting in substantial economic losses. However, traditional disease models often fail to capture the full complexity of viral pathogenesis. Pluripotent and tissue stem cell-derived org...
Structural constraints prevent a bat norovirus from binding to histo-blood group antigen co-factors [0.03%]
结构约束限制了蝙蝠诺如病毒与 histo- 血型表位共因子结合的能力
Dayna L Holroyd,John B Bruning,Mark von Itzstein et al.
Dayna L Holroyd et al.
TGF-β inhibitor SB431542 suppresses SARS-CoV-2 replication through multistep inhibition [0.03%]
TGFB抑制剂SB431542通过多步抑制作用抑制SARS-CoV-2复制
Assim Verma,Himanshu Kamboj,Garvit Kumar et al.
Assim Verma et al.
The coronavirus disease 2019 (COVID-19) pandemic highlighted the critical need for broad-spectrum antivirals with high resistance barriers. Here, we demonstrate that SB431542, a selective TGF-β receptor I (ALK5) inhibitor, exhibits potent ...
Camptothecin, a topoisomerase I inhibitor, impedes productive herpes simplex virus type 1 infection [0.03%]
喜树碱通过抑制疱疹病毒HSV-1基因表达阻碍病毒感染细胞
Joseph R Heath,Alison E Lloyd,Raegen M Kulinski et al.
Joseph R Heath et al.
Herpes simplex virus type 1 (HSV-1) is a double-stranded DNA virus that infects most of the human population. We previously found that cellular topoisomerase I (TOP1) associates with the HSV-1 genome throughout infection. TOP1 relieves topo...
Human cytomegalovirus-encoded G protein-coupled receptor (GPCR) UL78 regulates viral reactivation [0.03%]
人巨细胞病毒编码的G蛋白偶联受体（GPCR）UL78调节病毒再活化
Samuel A Osanyinlusi,Vargab Baruah,Ian J Groves et al.
Samuel A Osanyinlusi et al.
Human cytomegalovirus (CMV) is a ubiquitous pathogen that establishes lifelong, latent infection in hematopoietic cells. Immune-competent individuals are usually asymptomatic for disease. However, immune dysregulation in latently infected i...
Contemporary seasonal human coronaviruses display differences in cellular tropism compared to laboratory-adapted reference strains [0.03%]
与实验室适应的参考株相比，当代季节性人类冠状病毒表现出不同的细胞嗜性
Matthew J Gartner,Monique L Smith,Clyde Dapat et al.
Matthew J Gartner et al.
Seasonal human coronaviruses (sHCoVs) cause 15%-30% of common colds. The reference strains used for research were isolated decades ago and have been passaged extensively, but contemporary sHCoVs have been challenging to study as they are no...
An emerging PB2-627 polymorphism increases the zoonotic risk of avian influenza virus by overcoming ANP32 host restriction in mammalian and avian hosts [0.03%]
PB2蛋白第627位氨基酸多态性通过克服ANP32宿主限制因子增加禽流感病毒跨种间传播潜力
Yuxin Guo,Sicheng Shu,Yong Zhou et al.
Yuxin Guo et al.
Alterations in the PB2-627 domain of avian influenza virus (AIV) can potentially increase the risk of cross-host species infections in humans and mammals. Recently, there has been a rise in human cases of AIV infections without the presence...
A modification to heptad repeat 1 of gp41 improves yield and/or quality of soluble pre-fusion HIV-1 envelope glycoprotein trimers [0.03%]
修改gp41的七肽重复区1可提高可溶性HIV-1包膜三聚体产量和/或质量
Devidas N Chaturbhuj,Kwinten Sliepen,Albert Cupo et al.
Devidas N Chaturbhuj et al.
Native-like HIV-1 envelope glycoprotein (Env) trimers, exemplified by the SOSIP design, are widely used as immunogens, analytical antigens, and for structural studies. These vaccine research and development programs require trimers that are...