Completion of the 5' end of the porcine teschovirus genome reveals a functional S-segment and enables reverse genetics [0.03%]
猪 teschovirus基因组的5'端完成测序揭示了功能性S片段并能实现反向遗传学
Sebastian Affeldt,Sandra Barth,Stephanie Schlimbach et al.
Sebastian Affeldt et al.
Porcine teschoviruses (PTVs) are swine-specific picornaviruses associated with neurological and systemic disease, ranging from severe paralytic Teschen disease to milder forms of porcine encephalomyelitis, known as Talfan disease. Despite t...
Intragenic transcription from defective HIV proviruses triggers interferon responses in myeloid cells [0.03%]
缺陷HIV前病毒的内含子转录触发髓样细胞的干扰素反应
Jonathan M Kilroy,Aparna A Deokar,Samantha Patalano et al.
Jonathan M Kilroy et al.
The persistent HIV-1 reservoir includes a subset of cells harboring transcriptionally repressed latent HIV-1 that contributes to rebound upon antiretroviral treatment (ART) interruption. However, the majority of the reservoir consists of de...
Evidence for the acquisition of a proteorhodopsin-like rhodopsin by a chrysophyte-infecting giant virus [0.03%]
有关巨大病毒从黄藻中获取视紫红质的证据
Petra Byl,Christopher R Schvarcz,Julie Thomy et al.
Petra Byl et al.
Chrysophytes are nanoflagellate protists widespread in aquatic ecosystems with diverse trophic roles as primary producers and bacterivores. Molecular evidence suggests that chrysophytes are commonly infected by giant viruses, but isolates o...
Nuclear activities and interactome of the NS5 protein of tick-borne encephalitis virus [0.03%]
蜱脑炎病毒NS5蛋白的核定位及其作用底物谱分析
Maxime Chazal,Aïssatou Aïcha Sow,Elodie Le Seac&#x;h et al.
Maxime Chazal et al.
Orthoflaviviruses are RNA viruses responsible for significant diseases in humans, domesticated animals, and wildlife. Their NS5 protein is central in viral replication, functioning both as an RNA-dependent RNA polymerase and a methyltransfe...
Acquisition of specific human respiratory tract binding by 2.3.4.4b H5N1 hemagglutinins requires multiple mutations [0.03%]
禽流感病毒H5N1血凝素蛋白亚型2.3.4.4b获得与人呼吸道特异结合能力需要多个位点突变
María Ríos Carrasco,Mafalda F Guerreiro Cabana,Eszter Kovács et al.
María Ríos Carrasco et al.
It has been suggested that the hemagglutinin of the human-infecting cattle-derived 2.3.4.4b virus A/Texas/34 H5N1 (H5TX) requires only one mutation, namely Q226L, to switch from binding avian-type to human-type receptor preference. In this ...
Integration of a multimeric STAT consensus site into the adenoviral genome to interfere with IFN signaling represents a novel concept to improve oncolytic virotherapy [0.03%]
将一个多聚体信号转导及转录激活蛋白共识位点整合到腺病毒基因组中，以干扰I型干扰素信号通路，从而改善溶瘤病毒疗法的新概念
Dongbiao Wang,Sonja Nassua,Klaus Mantwill et al.
Dongbiao Wang et al.
Adenovirus infection triggers an interferon (IFN) response that reduces replication of the viral genome early in the adenoviral life cycle. In oncolytic virus therapy, viral replication is essential for effective cell lysis, which subsequen...
The conserved QTQTX motif in the SARS-CoV-2 spike protein is dispensable for cleavage and lung cell entry of the emerging variant BA.3.2 [0.03%]
新冠病毒BA.3.2变异株的S蛋白中保守的QTQTX位点对于蛋白切割和肺细胞侵入并非必需
Lu Zhang,Nianzhen Chen,Amy Eichmann et al.
Lu Zhang et al.
The furin motif in the SARS-CoV-2 spike (S) protein is important for lung cell entry. It is embedded in an extended loop structure and preceded by a highly conserved QTQTX motif that is required for efficient furin cleavage of the SARS-CoV-...
Competition assays reveal a contribution of the C4 protein CCL-like domain to the fitness of tomato yellow leaf curl virus in the host plant [0.03%]
竞争实验揭示C4蛋白CCL样结构域对黄叶卷曲病毒株系在寄主植物中适应性的影响
Man Gao,Chaonan Shi,Stephane Blanc et al.
Man Gao et al.
Keira R Ylvisaker,Gopishankar Thirumoorthy,Emma Wisniewski et al.
Keira R Ylvisaker et al.
High-risk human papillomaviruses (HPVs) cause cervical, anogenital, and head and neck cancers. A key oncogenic mechanism involves viral exploitation of host DNA damage tolerance pathways to support productive replication, a process that als...
One virus-many strategies: type-specific interactions between human adenoviruses and innate immunity [0.03%]
一个病毒多种策略：人腺病毒与先天性免疫类型特异性相互作用
Lisa Hanrieder,Sabrina Schreiner
Lisa Hanrieder
Human adenoviruses (HAdVs) are double-stranded DNA viruses that can cause a wide range of infections, including respiratory, gastrointestinal, and ocular diseases, as well as less common conditions such as hepatitis, hemorrhagic cystitis, a...