Formulation and Characterization of Novel Oral pH-Sensitive Electrospun Nanofibers for Boosting Dissolution and Penetration of Model Class IV Drug [0.03%]
一种新型口服pH值敏感型静电纺纳米纤维的制备及其促四类模型药物溶解和渗透性能的研究
Omar Y Mady,Safaa Khaled,Asmaa A Hedaya et al.
Omar Y Mady et al.
Sulpiride, (a model class IV drug) is a central dopamine antagonist, that is commonly used in the treatment of various psychiatric and gastrointestinal conditions. However, its poor aqueous solubility and low oral bioavailability (20-30%) l...
Gum Tragacanth-Based Hemostatic Sponge for Enhanced Hemostasis in Dental Surgery [0.03%]
一种基于虎明胶的止血海绵用于牙科手术中的增强型止血功能
Mirmousa Mousavai,Ramin Khajavi,Mohammadreza Kalaee et al.
Mirmousa Mousavai et al.
Regulating hemorrhage is crucial during dental procedures, particularly surgical interventions where substantial blood loss may occur. Hemostatic sponges are effective instruments for controlling hemorrhage, facilitating hemostasis, prepari...
Impact of medication swallowing lubricants on the in vitro dissolution of crushed and whole metformin tablets: dissolution kinetics study [0.03%]
润滑剂对孟氟茋完整片和碎粉体中溶解度的影响：溶解动力学研究
Vivek Babu Nooney,Thilini Thrimawithana,Barbora de Courten et al.
Vivek Babu Nooney et al.
Metformin is the most common drug used in patients with type 2 diabetes. Our aim is to assess if the in vitro dissolution of Metformin IR 500 mg tablets and its kinetics is altered in the presence of various medication swallowing lubricants...
Cationic Nanocrystalline Suspensions: A Potential Approach for Nose to Brain Delivery of L-Dopa in Parkinson's Therapy [0.03%]
阳离子纳米晶悬浮液在帕金森病治疗中用于左旋多巴鼻用给药的潜在方法研究
Chiedza Kakono,Bwalya A Witika,Pedzisai A Makoni et al.
Chiedza Kakono et al.
Levodopa (L-dopa) is the most effective treatment for Parkinson's disease, but it exhibits low oral bioavailability. Intranasal L-dopa nanosuspensions were manufactured to improve bioavailability using the olfactory and trigeminal delivery ...
Development of molnupiravir and peramivir loaded liposome formulations for combined antiviral therapy [0.03%]
莫努匹拉韦和帕拉米韦载药脂质体制剂的开发用于联合抗病毒疗法
Hadiye Keskin,Tuba Reçber,Nazlıcan Filazi et al.
Hadiye Keskin et al.
The pandemic caused by the SARS-CoV-2 virus has led scientists to intensify research on antiviral drugs and vaccines. As a result of these studies, it was observed that molnupiravir (MLP) and peramivir (PRV) could be used against pandemic. ...
Amelioration of Imiquimod-induced Psoriasis in the Mice model by Topical Delivery of Phosphodiesterase 4 Inhibitor Roflumilast Incorporated Nanoemulgel [0.03%]
纳米乳凝胶递送磷odiester酶4抑制剂Roflumilast改善小鼠因咪喹莫德引起的银屑病
Velpula Prasannanjaneyulu,Shweta Nene,Ganesh Vambhurkar et al.
Velpula Prasannanjaneyulu et al.
Several clinical trials on repurposing of roflumilast are in progress, majorly focused on the potential treatment for psoriasis and atopic dermatitis like inflammatory skin diseases. Therefore, the current research focuses on formulation an...
Topical Hyalubilosomes of dantrolene sodium as muscle targeted nanocarrier for muscle spasms: Fabrication, ex-vivo permeation and behavioral animal model [0.03%]
丹曲林钠 topical hyaluronic acid bilosome 纳米载体的制备及透皮实验和动物行为学研究
Abdelrahaman Mm Othman,Ossama Y Abdallah,Yosra Sr Elnaggar
Abdelrahaman Mm Othman
The development of topical muscle relaxants has gained significant attention in the pharmaceutical field. Dantrolene sodium (DS), an FDA-approved muscle relaxant, acts locally on muscle by targeting the ryanodine receptor. However, its clin...
Lycopene-Carrier Solid Dispersion loaded Lipid Liquid Crystal Nanoparticle: in vitro Evaluation and in vivo Wound Healing Effects [0.03%]
一种载有番茄红素固体分散体的脂质液晶型纳米颗粒：体外评价与体内促伤口愈合作用
Farhad Shahverdi,Elham Khodaverdi,Jebrail Movaffagh et al.
Farhad Shahverdi et al.
This study was conducted to develop a lycopene-carrier solid dispersion-loaded lipid liquid crystal nanoparticle (LLC) formulation aimed at enhancing aqueous solubility, bioavailability, and wound healing efficacy. Lycopene was extracted fr...
Solid Supersaturated Self-Nanoemulsifying Drug Delivery System for Abiraterone Acetate: Improved Drug loading, Dissolution, Cellular Uptake and Anticancer Activity [0.03%]
用于阿比特龙乙酸盐的固体超饱和自纳米乳化药物递送系统：提高载药量，溶出度，细胞摄取及抗癌活性
Ayush Nair,Mayur Aalhate,Srushti Mahajan et al.
Ayush Nair et al.
Abiraterone acetate (ABT) is an androgen biosynthesis inhibitor approved for the treatment of prostate cancer. However, the treatment course of ABT is constrained by its high dose, poor solubility and permeability issues. A solid supersatur...
Enzyme-sensitive peptide KC26 modifies milk exosomes encapsulating carboplatin for the treatment of retinoblastoma [0.03%]
酶敏感肽KC26修饰包含卡铂的乳汁外泌体以治疗视网膜母细胞瘤
Hetong Wang,Wei Wang,Qin Tang et al.
Hetong Wang et al.
Milk exosomes have also been widely used as emerging delivery vehicles for various therapeutic cargoes. Retinoblastoma (RB) is the most common primary intraocular malignancy of childhood. However, the therapeutic efficacy is severely hamper...