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Cationic Nanocrystalline Suspensions: A Potential Approach for Nose to Brain Delivery of L-Dopa in Parkinson's Therapy

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Levodopa (L-dopa) is the most effective treatment for Parkinson's disease, but it exhibits low oral bioavailability. Intranasal L-dopa nanosuspensions were manufactured to improve bioavailability using the olfactory and trigeminal delivery routes for direct b... ...