A dysregulated hepcidin-iron axis impairs antiviral immunity and induces lethal liver pathology in neonates [0.03%]
铁调节紊乱影响抗病毒免疫并导致新生儿致命性肝病
Yanhui Xu,Xixi Chen,Rongli Fang et al.
Yanhui Xu et al.
Systemic rotavirus (RV) infection poses a substantial health challenge in neonates, but the underlying pathogenesis remains elusive. In RV-infected neonatal mice and infants with biliary atresia (BA), we discovered that persistent type I in...
A chemical agonist and the Golgi-resident lipid PI4P activate STING by inducing transmembrane helix rearrangement [0.03%]
化学激动剂和高尔基体驻留脂质PI4P通过诱导跨膜螺旋重排激活STING
Jing Han,Shuhao Zhang,Yanfei Hou et al.
Jing Han et al.
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway is critical in innate immunity. Recent research has highlighted the importance of phosphatidylinositol 4-phosphate (PI4P) signaling within the Golgi...
Takahiro Yamada,Noah W Palm
Takahiro Yamada
Host-associated microbes produce thousands of metabolites that influence diverse aspects of mammalian physiology, including the immune system. However, the organizing principles governing these interactions remain largely unclear. Here, we ...
Britta Simons,Hieu Trong Nguyen,Atscharah Panyot et al.
Britta Simons et al.
Immunoglobulin A (IgA) is the most abundantly produced antibody isotype and mediates protection and homeostatic regulation at mucosal surfaces. Steady-state IgA production is supported by multiple pathways, including chronic germinal center...
Ananya Saha,Hasan Ahmed,Cora Hirst et al.
Ananya Saha et al.
Immunological memory is a defining feature of immunity, and a quantitative description of how it wanes would help better understand the processes underlying its maintenance and estimate the duration of protection after immunization. We anal...
Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils [0.03%]
深度剖析人类T细胞可定义血液和扁桃体中的隔室克隆和表型轨迹
Suhas Sureshchandra,James Henderson,Elizabeth Levendosky et al.
Suhas Sureshchandra et al.
98% of T cells reside in tissues, yet nearly all human T cell analyses are performed on peripheral blood. We performed single-cell sequencing of 5.7 million T cells from autologous blood and tonsils of ten donors. We identified distinct pat...
Human lung CD8+ tissue-resident memory T cell-derived interferon-γ orchestrates subset-specific antiviral programming in airway epithelial cells [0.03%]
人肺驻留记忆T细胞源性干扰素-γ调控呼吸道上皮细胞的抗病毒程序化
Cameron L R Mattingly,Ariana R Jimenez,M Elliott Williams et al.
Cameron L R Mattingly et al.
Lung resident CD8+ T cells are situated at the site of initial viral entry and replication. Here, we examined the phenotypic profiles and effector functions of human lung CD8+ T cells specific for four prevalent human viruses-influenza, res...
Topography of the HLA-A protein enforces shared and convergent immunodominant B cell and antibody alloresponses in transplant recipients [0.03%]
移植受者中的HLA-A蛋白拓扑结构决定免疫主导的B细胞和抗体alloresponse共性和趋同性
John T Killian Jr,R Glenn King,Aaron C K Lucander et al.
John T Killian Jr et al.
Donor-specific antibody responses against human leukocyte antigen (HLA) proteins mismatched between transplant donors and recipients cause allograft loss, yet the structural HLA epitopes targeted by alloreactive B cells and antibodies remai...
IL-9 signaling redirects CAR T cell fate toward CD8+ memory and CD4+ cycling states, enhancing antitumor efficacy [0.03%]
IL-9信号传导将CAR-T细胞命运重新定向到CD8+记忆和CD4+周期状态，从而增强抗肿瘤功效
Sofía Castelli,Wesley V Wilson,Ugur Uslu et al.
Sofía Castelli et al.
The success of chimeric antigen receptor (CAR) T cell therapies targeting solid tumors is limited by the immunosuppressive tumor microenvironment. We demonstrate that endowing CAR T cells with ectopic interleukin (IL)-9 signaling by co-expr...
Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation [0.03%]
病毒感染诱导的膜完整性改变通过SMPDL3B降解cGAMP来限制cGAS-STING信号转导
Zhimeng Wang,Yanfei Hou,Peiyuan Liu et al.
Zhimeng Wang et al.
Published Erratum
Immunity. 2025 Nov 21:S1074-7613(25)00515-1. DOI:10.1016/j.immuni.2025.11.013 2025